Targets miRBase

hsa-miR-22-3p (MIMAT0000077) (134 targets) in miRTarBase

References

authors journal year Pubmed link title
1 Jazbutyte et al. Age (Dordr) 2013 22538858 MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.
2 Iliopoulos et al. PLoS ONE 2008 19011694 Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks.
3 Long et al. J. Biol. Chem. 2013 24163368 MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
4 McManus et al. J. Exp. Med. 2008 18347104 Michael T. McManus: Interrupting biology [interview by Hema Bashyam].
5 Pandey et al. Mol. Cell. Biol. 2009 19414598 miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA.
6 Zhang et al. Br. J. Cancer 2010 20842113 microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity.
7 Jovicic et al. PLoS ONE 2013 23349832 MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.
8 Schaar et al. Exp. Hematol. 2009 19135902 miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation.
9 Xiong et al. Oncogene 2010 20562918 Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.
10 Muiños-Gimeno et al. Biol. Psychiatry 2011 21168126 Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways.
11 Takata et al. Biochem. Biophys. Res. Commun. 2011 21798241 MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators.
12 Chang et al. Proc. Natl. Acad. Sci. U.S.A. 2012 22447776 Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.
13 Ling et al. J. Cancer Res. Clin. Oncol. 2012 22484852 Tumor suppressor miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3.
14 Tsuchiya et al. Cancer Res. 2011 21565979 Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.
15 Chen et al. PLoS ONE 2012 22493679 MicroRNA-22 can reduce parathymosin expression in transdifferentiated hepatocytes.
16 Poliseno et al. Sci Signal 2010 20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
17 Polioudakis et al. Nucleic Acids Res. 2013 23303785 A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes.
18 Xu et al. J. Cell Biol. 2011 21502362 miR-22 represses cancer progression by inducing cellular senescence.
19 Guo et al. Med. Oncol. 2013 23529765 miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1.
20 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
21 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
22 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
23 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
24 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
25 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
26 Huang et al. Stem Cells Dev. 2012 22375943 Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression.
27 Song et al. Cell Stem Cell 2013 23827711 The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.
28 Song et al. Cell 2013 23830207 MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.
29 Shi et al. Biomed. Pharmacother. 2013 23582783 MicroRNA-22 is down-regulated in hepatitis B virus-related hepatocellular carcinoma.
30 Tang et al. Cancer Lett. 2013 23851184 Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
31 Wang et al. Biochem. Biophys. Res. Commun. 2014 24495805 MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151.
32 Lin et al. Arthritis Rheumatol. 2014 24449575 A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis.
33 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
34 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
35 White et al. Br. J. Cancer 2014 24496460 Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.
36 Kong et al. Cancer Res. 2014 24906624 A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis.
37 Riepsaame et al. Front Immunol 2013 24198819 MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells.
38 Ahmad et al. FEBS J. 2014 25041463 miR-22 regulates expression of oncogenic neuro-epithelial transforming gene 1, NET1.
39 Li et al. Oncol. Rep. 2013 23440286 miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9.
40 Zhang et al. Cancer Lett. 2015 25449431 MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells.
41 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
42 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
43 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
44 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
45 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
This website uses Matomo Analytics and cookies. For more information, please refer to the privacy notice for our websites. Learn moreI agree