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hsa-miR-34c-5p (MIMAT0000686) (137 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-34c-5p Bcl2
Western blot [1]
Luciferase reporter assay [1]
hsa-miR-34c-5p Sgcb
Luciferase reporter assay [2]
hsa-miR-34c-5p MYB
microarray [3]
hsa-miR-34c-5p CAV1
microarray [3]
hsa-miR-34c-5p MET
microarray [4]
RT-PCR [4]
Western blot [4]
Luciferase reporter assay [5] [3] [6] [7]
hsa-miR-34c-5p E2F3
qRT-PCR [8]
Immunofluorescence [8]
Western blot [9] [8]
Immunocytochemistry [8]
Luciferase reporter assay [3] [9] [8]
PAR-CLIP [10]
hsa-miR-34c-5p CDK4
microarray [4]
RT-PCR [4]
Western blot [4]
Luciferase reporter assay [3]
hsa-miR-34c-5p CCNE2
Luciferase reporter assay [3]
PAR-CLIP [11]
hsa-miR-34c-5p BCL2
qRT-PCR [12] [13]
Western blot [12] [13]
Luciferase reporter assay [12]
hsa-miR-34c-5p MYC
qRT-PCR [14]
microarray [14]
Western blot [14]
Luciferase reporter assay [3] [14]
Immunoprecipitaion [14]
TRAP [15]
hsa-miR-34c-5p SRSF2
microarray [3]
hsa-miR-34c-5p CDK6
PAR-CLIP [16]
hsa-miR-34c-5p ZAP70
Immunoblot [17]
Luciferase reporter assay [17]
hsa-miR-34c-5p NOTCH4
Western blot [18]
Luciferase reporter assay [18]
EMSA [18]
hsa-miR-34c-5p MYCN
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-34c-5p SOX2
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-34c-5p NANOG
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-34c-5p HNF4A
Luciferase reporter assay [20] [21]
hsa-miR-34c-5p ULBP2
Western blot [22]
Luciferase reporter assay [22]
Flow cytometry [22]
hsa-miR-34c-5p NOTCH1
qRT-PCR [23] [24]
microarray [23]
Western blot [23] [24]
Luciferase reporter assay [23] [24]
hsa-miR-34c-5p MAPT
Luciferase reporter assay [25]
hsa-miR-34c-5p UNG
Luciferase reporter assay [26]
hsa-miR-34c-5p SNAI1
qRT-PCR [27]
Western blot [27]
Luciferase reporter assay [27]
hsa-miR-34c-5p BMF
qRT-PCR [28]
Immunoblot [28]
Luciferase reporter assay [28]
Immunoprecipitaion [28]
hsa-miR-34c-5p PDGFRA
qRT-PCR [29]
In situ hybridization [29]
Western blot [29]
Luciferase reporter assay [29]
hsa-miR-34c-5p PDGFRB
qRT-PCR [29]
In situ hybridization [29]
Western blot [29]
Luciferase reporter assay [29]
hsa-miR-34c-5p VEZT
qRT-PCR [30]
Western blot [30]
Luciferase reporter assay [30]
hsa-miR-34c-5p YY1
qRT-PCR [31]
Western blot [31]
Luciferase reporter assay [31]
Flow cytometry [31]
hsa-miR-34c-5p RARG
qRT-PCR [32]
Luciferase reporter assay [32]
hsa-miR-34c-5p RUNX2
qRT-PCR [33]
Western blot [33]
Luciferase reporter assay [33]
hsa-miR-34c-5p ZDHHC16
PAR-CLIP [34]
hsa-miR-34c-5p FAM104A
PAR-CLIP [10]
hsa-miR-34c-5p HSPA1B
PAR-CLIP [10]
hsa-miR-34c-5p MAZ
qRT-PCR [35]
Western blot [35]
Luciferase reporter assay [35]
PAR-CLIP [16]
immunofluorescence assays [35]
hsa-miR-34c-5p TXNIP
PAR-CLIP [11] [10]
hsa-miR-34c-5p DCTN5
PAR-CLIP [11]
hsa-miR-34c-5p CCL22
PAR-CLIP [16]
hsa-miR-34c-5p GIGYF1
PAR-CLIP [11] [36]
hsa-miR-34c-5p MDM4
PAR-CLIP [16]
hsa-miR-34c-5p SMAD4
PAR-CLIP [10]
hsa-miR-34c-5p TSN
PAR-CLIP [10] [16]
hsa-miR-34c-5p CBX3
PAR-CLIP [34]
hsa-miR-34c-5p EVI5L
PAR-CLIP [34]
hsa-miR-34c-5p ZNF551
PAR-CLIP [11] [10]
hsa-miR-34c-5p TGFBR2
PAR-CLIP [37]
hsa-miR-34c-5p TM9SF3
PAR-CLIP [10] [34] [11]
hsa-miR-34c-5p UBXN2B
PAR-CLIP [11]
hsa-miR-34c-5p MBD6
PAR-CLIP [16]
hsa-miR-34c-5p CDH1
qRT-PCR [38]
hsa-miR-34c-5p PTENP1
qRT-PCR [38]
hsa-miR-34c-5p HSP90AA1
qRT-PCR [38]
hsa-miR-34c-5p PABPC1
qRT-PCR [39]
Western blot [39]
hsa-miR-34c-5p GALNT7
qRT-PCR [40]
Western blot [40]
Luciferase reporter assay [40]
hsa-miR-34c-5p FOSL1
qRT-PCR [41]
Immunoblot [41]
Luciferase reporter assay [41]
hsa-miR-34c-5p IL6R
qRT-PCR [42]
ChIP [42]
Immunofluorescence [42]
Western blot [42]
hsa-miR-34c-5p ITPR1
qRT-PCR [13]
Western blot [13]
hsa-miR-34c-5p MAP2K1
qRT-PCR [13]
Western blot [13]
hsa-miR-34c-5p DNAAF3
PAR-CLIP [43]
hsa-miR-34c-5p MFSD8
PAR-CLIP [43]
hsa-miR-34c-5p CTIF
PAR-CLIP [43]
hsa-miR-34c-5p GMFB
PAR-CLIP [43]
hsa-miR-34c-5p HIRIP3
PAR-CLIP [16]
hsa-miR-34c-5p GPR156
PAR-CLIP [16]
hsa-miR-34c-5p CNOT4
PAR-CLIP [10] [34] [16]
hsa-miR-34c-5p SLC4A2
PAR-CLIP [16]
hsa-miR-34c-5p PLA2G2D
PAR-CLIP [16]
hsa-miR-34c-5p SPAM1
PAR-CLIP [16]
hsa-miR-34c-5p EFNB1
PAR-CLIP [16]
hsa-miR-34c-5p UST
PAR-CLIP [16]
hsa-miR-34c-5p TNRC18P2
PAR-CLIP [11] [10] [34] [16] [36]
hsa-miR-34c-5p SYNGR2
PAR-CLIP [16]
hsa-miR-34c-5p SF3B3
PAR-CLIP [16]
hsa-miR-34c-5p RGP1
PAR-CLIP [16]
hsa-miR-34c-5p KMT2D
PAR-CLIP [16]
hsa-miR-34c-5p IFNLR1
PAR-CLIP [16]
hsa-miR-34c-5p EDEM3
PAR-CLIP [16]
hsa-miR-34c-5p DYRK3
PAR-CLIP [16]
hsa-miR-34c-5p DDX19B
PAR-CLIP [16]
hsa-miR-34c-5p BAZ2A
PAR-CLIP [16]
hsa-miR-34c-5p ATXN1L
PAR-CLIP [16]
hsa-miR-34c-5p COPZ1
PAR-CLIP [16]
hsa-miR-34c-5p CYTH3
PAR-CLIP [16]
hsa-miR-34c-5p SSBP2
PAR-CLIP [16]
hsa-miR-34c-5p SHMT1
PAR-CLIP [37] [16]
hsa-miR-34c-5p LNPK
PAR-CLIP [16]
hsa-miR-34c-5p NEUROD2
PAR-CLIP [16]
hsa-miR-34c-5p MKNK2
PAR-CLIP [16]
hsa-miR-34c-5p FOXN3
PAR-CLIP [34] [16]
hsa-miR-34c-5p ARHGAP1
PAR-CLIP [16] [10] [34]
hsa-miR-34c-5p MAST3
PAR-CLIP [44]
hsa-miR-34c-5p FICD
PAR-CLIP [11] [10]
hsa-miR-34c-5p ZNF623
PAR-CLIP [11]
hsa-miR-34c-5p RTL8A
PAR-CLIP [11]
hsa-miR-34c-5p ZNF644
PAR-CLIP [11]
hsa-miR-34c-5p TMEM167A
PAR-CLIP [11]
hsa-miR-34c-5p SHOC2
PAR-CLIP [11]
hsa-miR-34c-5p SESN2
PAR-CLIP [11]
hsa-miR-34c-5p SATB2
HITS-CLIP [45]
PAR-CLIP [34] [11]
hsa-miR-34c-5p PHF19
PAR-CLIP [11]
hsa-miR-34c-5p PEG10
PAR-CLIP [11]
hsa-miR-34c-5p CDKN1B
PAR-CLIP [11]
hsa-miR-34c-5p BCL2L13
PAR-CLIP [11] [10]
hsa-miR-34c-5p ZRSR1
PAR-CLIP [11] [10]
hsa-miR-34c-5p XBP1P1
PAR-CLIP [11] [10]
hsa-miR-34c-5p GAS1
PAR-CLIP [11] [10] [34]
hsa-miR-34c-5p UBL4A
PAR-CLIP [11]
hsa-miR-34c-5p VPS37B
PAR-CLIP [11]
hsa-miR-34c-5p SAR1A
PAR-CLIP [11]
hsa-miR-34c-5p RRAGD
PAR-CLIP [11] [10]
hsa-miR-34c-5p C18orf32
PAR-CLIP [37]
hsa-miR-34c-5p RWDD2A
PAR-CLIP [37] [10]
hsa-miR-34c-5p PODXL
PAR-CLIP [37]
hsa-miR-34c-5p KBTBD6
PAR-CLIP [10] [34]
hsa-miR-34c-5p HSPA13
PAR-CLIP [34]
hsa-miR-34c-5p BMP3
PAR-CLIP [34]
hsa-miR-34c-5p SLC35G2
PAR-CLIP [34]
hsa-miR-34c-5p MOAP1
PAR-CLIP [34]
hsa-miR-34c-5p HOXA13
PAR-CLIP [34]
hsa-miR-34c-5p GXYLT2
PAR-CLIP [34]
hsa-miR-34c-5p MIGA1
PAR-CLIP [34]
hsa-miR-34c-5p VPS37D
PAR-CLIP [10]
hsa-miR-34c-5p TPCN2
PAR-CLIP [10]
hsa-miR-34c-5p PAPLN
PAR-CLIP [10]
hsa-miR-34c-5p APOPT1
PAR-CLIP [10]
hsa-miR-34c-5p VASN
PAR-CLIP [10]
hsa-miR-34c-5p VAV3
HITS-CLIP [46] [47]
hsa-miR-34c-5p ITGA11
HITS-CLIP [48] [47]
hsa-miR-34c-5p SSX5
HITS-CLIP [45]
hsa-miR-34c-5p DDA1
HITS-CLIP [45]
hsa-miR-34c-5p CPEB3
HITS-CLIP [45]
hsa-miR-34c-5p CLIC5
HITS-CLIP [45]
hsa-miR-34c-5p IER5
HITS-CLIP [45]
hsa-miR-34c-5p AASDHPPT
HITS-CLIP [45]
hsa-miR-34c-5p ITGB3
HITS-CLIP [45]
hsa-miR-34c-5p POTED
HITS-CLIP [48]
hsa-miR-34c-5p JARID2
HITS-CLIP [48]
hsa-miR-34c-5p MKLN1
HITS-CLIP [49]

References

authors journal year Pubmed link title
1 Liu et al. Proc. Natl. Acad. Sci. U.S.A. 2012 22203953 Sperm-borne microRNA-34c is required for the first cleavage division in mouse.
2 Xu et al. J. Cell. Sci. 2012 23038777 Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p.
3 Hermeking et al. Cell Death Differ. 2010 19461653 The miR-34 family in cancer and apoptosis.
4 Suzuki et al. Carcinogenesis 2010 20924086 Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.
5 Hagman et al. Br. J. Cancer 2013 23922103 The tumour suppressor miR-34c targets MET in prostate cancer cells.
6 Cai et al. Int. J. Mol. Med. 2010 20198305 Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met.
7 Dong et al. Mol. Vis. 2012 22419847 MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets.
8 Zhou et al. Int. J. Biol. Sci. 2013 23983607 Elevated miR-34c-5p mediates dermal fibroblast senescence by ultraviolet irradiation.
9 Lujambio et al. Proc. Natl. Acad. Sci. U.S.A. 2008 18768788 A microRNA DNA methylation signature for human cancer metastasis.
10 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
11 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
12 Ji et al. BMC Cancer 2008 18803879 Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres.
13 An et al. Toxicol. Lett. 2014 24960059 The changes of miRNA expression in rat hippocampus following chronic lead exposure.
14 Benassi et al. Cancer Discov 2012 22585994 MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
15 Braun et al. Nucleic Acids Res. 2014 24510096 Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification).
16 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
17 Fabbri et al. JAMA 2011 21205967 Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.
18 Yu et al. J. Biol. Chem. 2012 22074923 MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells.
19 Choi et al. Nat. Cell Biol. 2011 22020437 miR-34 miRNAs provide a barrier for somatic cell reprogramming.
20 Wang et al. Biochim. Biophys. Acta 2013 23298640 The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation.
21 Ramamoorthy et al. Drug Metab. Dispos. 2012 22232426 In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.
22 Heinemann et al. Cancer Res. 2012 22102694 Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.
23 Bae et al. Hum. Mol. Genet. 2012 22498974 miRNA-34c regulates Notch signaling during bone development.
24 Cama et al. Acta Neuropathol. 2013 23955600 Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling.
25 Wu et al. Cancer Chemother. Pharmacol. 2013 23423488 Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel.
26 Hegre et al. DNA Repair (Amst.) 2013 23228472 Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.
27 Siemens et al. Cell Cycle 2011 22134354 miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.
28 Catuogno et al. Oncogene 2013 22370637 miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis.
29 Garofalo et al. PLoS ONE 2013 23805317 MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.
30 Guo et al. Biochem. Biophys. Res. Commun. 2011 21156161 Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c.
31 Wang et al. Oncotarget 2014 24970812 Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis.
32 Zhang et al. Cell Biochem. Funct. 2012 23097316 MIR-34c regulates mouse embryonic stem cells differentiation into male germ-like cells through RARg.
33 van der Deen et al. J. Biol. Chem. 2013 23720736 MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma.
34 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
35 Zhao et al. J. Cell. Physiol. 2015 25201524 miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.
36 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
37 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
38 Li et al. PLoS ONE 2013 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
39 Zhu et al. Int J Clin Exp Pathol 2015 26097561 PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c.
40 Li et al. Mol Med Rep 2014 24482044 MicroRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression.
41 Yang et al. Oncogene 2013 23001043 MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1.
42 Rokavec et al. J. Clin. Invest. 2014 24642471 IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
43 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
44 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
45 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
46 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
47 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
48 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
49 Haecker et al. PLoS Pathog. 2012 22927820 Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
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