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hsa-miR-200a-3p (MIMAT0000682) (125 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-200a-3p DLX5
Luciferase reporter assay [1]
hsa-miR-200a-3p BAP1
microarray [2]
Reporter assay [3]
hsa-miR-200a-3p G3BP2
Northern blot [4]
microarray [4]
hsa-miR-200a-3p PCDH8
Northern blot [4]
microarray [4]
hsa-miR-200a-3p RAB30
Northern blot [4]
microarray [4]
hsa-miR-200a-3p ZEB2
qRT-PCR [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18]
microarray [9] [19] [17] [20]
In situ hybridization [19] [6]
Immunofluorescence [17] [6]
Western blot [5] [6] [7] [8] [9] [11] [12] [15] [14] [20] [16] [17]
Immunoblot [19]
Luciferase reporter assay [5] [9] [7] [10] [11] [21] [12] [18] [20] [14]
Flow cytometry [9]
Immunohistochemistry [12] [13] [6] [9]
intrarenal expression [22]
hsa-miR-200a-3p CTNNB1
qRT-PCR [23] [16] [7]
Reporter assay [7]
Western blot [7] [23] [16]
Luciferase reporter assay [16] [23] [7]
Flow cytometry [23]
hsa-miR-200a-3p GEMIN2
Reporter assay [14]
hsa-miR-200a-3p PDCD4
microarray [2]
hsa-miR-200a-3p GATA6
microarray [2]
PAR-CLIP [24]
hsa-miR-200a-3p VCAM1
microarray [2]
hsa-miR-200a-3p PSMD2
Northern blot [4]
microarray [4]
hsa-miR-200a-3p WASF3
Luciferase reporter assay [25]
hsa-miR-200a-3p TFRC
Northern blot [26]
hsa-miR-200a-3p ZFPM2
Reporter assay [3]
Western blot [3]
Luciferase reporter assay [3]
hsa-miR-200a-3p TRAPPC2B
Luciferase reporter assay [27]
hsa-miR-200a-3p GDAP1
Northern blot [28]
qRT-PCR [28]
In situ hybridization [28]
Immunofluorescence [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-200a-3p MAPK14
microarray [29]
Western blot [29]
HITS-CLIP [30]
Luciferase reporter assay [29]
hsa-miR-200a-3p CCNE2
Luciferase reporter assay [31]
hsa-miR-200a-3p KEAP1
qRT-PCR [32]
Western blot [32]
Luciferase reporter assay [32]
hsa-miR-200a-3p SRF
qRT-PCR [33]
Immunoblot [33]
Luciferase reporter assay [33]
hsa-miR-200a-3p SMAD2
Luciferase reporter assay [34]
hsa-miR-200a-3p SMAD3
Luciferase reporter assay [34]
hsa-miR-200a-3p YAP1
Western blot [35]
hsa-miR-200a-3p KLHL20
Reporter assay [3]
hsa-miR-200a-3p PTPRD
Reporter assay [3]
hsa-miR-200a-3p ELMO2
Reporter assay [3]
hsa-miR-200a-3p ERBIN
Reporter assay [3]
hsa-miR-200a-3p WDR37
Reporter assay [3]
hsa-miR-200a-3p VAC14
Reporter assay [3]
hsa-miR-200a-3p SHC1
Reporter assay [3]
hsa-miR-200a-3p TCF7L1
Reporter assay [3]
hsa-miR-200a-3p RASSF2
Reporter assay [3]
hsa-miR-200a-3p RIN2
Reporter assay [3]
hsa-miR-200a-3p HOXB5
Reporter assay [3]
hsa-miR-200a-3p SEPT7
Reporter assay [3]
hsa-miR-200a-3p KLF11
Reporter assay [3]
hsa-miR-200a-3p MYB
qRT-PCR [36]
Western blot [36]
Luciferase reporter assay [36]
Flow cytometry [36]
hsa-miR-200a-3p TFAM
Western blot [37]
Luciferase reporter assay [37]
hsa-miR-200a-3p UBASH3B
qRT-PCR [38]
microarray [38]
Western blot [38]
Luciferase reporter assay [38]
Immunohistochemistry [38]
hsa-miR-200a-3p TP53
Western blot [39]
Luciferase reporter assay [39]
hsa-miR-200a-3p DNMT1
qRT-PCR [40]
ChIP [40]
Western blot [40]
hsa-miR-200a-3p EZH2
qRT-PCR [40]
ChIP [40]
Western blot [40]
hsa-miR-200a-3p PTEN
qRT-PCR [41]
Western blot [41]
PAR-CLIP [42]
hsa-miR-200a-3p HFE
qRT-PCR [43]
Western blot [43]
hsa-miR-200a-3p DLC1
qRT-PCR [43]
Western blot [43]
hsa-miR-200a-3p ATRX
qRT-PCR [43]
Western blot [43]
hsa-miR-200a-3p PPP1R15B
PAR-CLIP [42]
hsa-miR-200a-3p RAB8B
PAR-CLIP [44]
hsa-miR-200a-3p MED13
PAR-CLIP [45]
hsa-miR-200a-3p QKI
PAR-CLIP [44]
hsa-miR-200a-3p ADNP2
HITS-CLIP [46]
hsa-miR-200a-3p ARL5B
PAR-CLIP [47] [44] [24] [42] [45]
hsa-miR-200a-3p TNKS2
PAR-CLIP [24]
hsa-miR-200a-3p SPRYD4
PAR-CLIP [24]
hsa-miR-200a-3p OGT
PAR-CLIP [47] [24]
hsa-miR-200a-3p PGK1
PAR-CLIP [48]
hsa-miR-200a-3p ZBTB34
PAR-CLIP [42]
hsa-miR-200a-3p HNRNPAB
PAR-CLIP [44]
hsa-miR-200a-3p IPO5
PAR-CLIP [47]
hsa-miR-200a-3p AREG
qRT-PCR [49]
microarray [49]
Western blot [49]
Luciferase reporter assay [49]
Immunoprecipitaion [49]
Immunohistochemistry [49]
ELISA [49]
hsa-miR-200a-3p GRB2
Luciferase reporter assay [50]
hsa-miR-200a-3p CDK6
qRT-PCR [51]
Western blot [51]
Luciferase reporter assay [51]
hsa-miR-200a-3p STXBP2
PAR-CLIP [52]
hsa-miR-200a-3p SEPT8
PAR-CLIP [52]
hsa-miR-200a-3p DPY19L1
PAR-CLIP [52]
hsa-miR-200a-3p CHML
PAR-CLIP [52]
hsa-miR-200a-3p NDST4
PAR-CLIP [52]
hsa-miR-200a-3p TRAM1
PAR-CLIP [42]
hsa-miR-200a-3p YRDC
HITS-CLIP [24]
PAR-CLIP [44] [24] [48] [42] [45] [47]
hsa-miR-200a-3p PSMD11
PAR-CLIP [42]
hsa-miR-200a-3p MCL1
PAR-CLIP [42]
hsa-miR-200a-3p CYP1B1
PAR-CLIP [42]
hsa-miR-200a-3p BICD2
PAR-CLIP [24] [42]
hsa-miR-200a-3p PRELID2
PAR-CLIP [53]
hsa-miR-200a-3p USP53
PAR-CLIP [45]
hsa-miR-200a-3p HNRNPF
PAR-CLIP [24] [45]
hsa-miR-200a-3p GNA13
PAR-CLIP [45]
hsa-miR-200a-3p FUT11
PAR-CLIP [24] [45]
hsa-miR-200a-3p EPHA2
PAR-CLIP [48] [45]
hsa-miR-200a-3p BRD3
PAR-CLIP [45]
hsa-miR-200a-3p TMOD3
PAR-CLIP [44] [47]
hsa-miR-200a-3p MARCH6
PAR-CLIP [47] [44] [24] [48]
hsa-miR-200a-3p KIAA1147
PAR-CLIP [47]
hsa-miR-200a-3p ZNF805
PAR-CLIP [47] [24]
hsa-miR-200a-3p ZMAT3
PAR-CLIP [47] [24]
hsa-miR-200a-3p MALT1
PAR-CLIP [48]
hsa-miR-200a-3p KIAA1549
PAR-CLIP [48]
hsa-miR-200a-3p ELAVL2
PAR-CLIP [48]
hsa-miR-200a-3p ATXN7L1
PAR-CLIP [48]
hsa-miR-200a-3p PIGW
PAR-CLIP [24]
hsa-miR-200a-3p EPHA7
PAR-CLIP [24]
hsa-miR-200a-3p C18orf25
PAR-CLIP [24]
hsa-miR-200a-3p SLC35D1
PAR-CLIP [24]
hsa-miR-200a-3p PGAM4
PAR-CLIP [24]
hsa-miR-200a-3p H2AFZ
PAR-CLIP [44] [24]
hsa-miR-200a-3p TRMT112
PAR-CLIP [44]
hsa-miR-200a-3p XPOT
PAR-CLIP [44]
hsa-miR-200a-3p CDV3
PAR-CLIP [44]
hsa-miR-200a-3p KIAA1549L
PAR-CLIP [44]
hsa-miR-200a-3p LHX1
HITS-CLIP [30]
hsa-miR-200a-3p YME1L1
HITS-CLIP [30]
hsa-miR-200a-3p APOOL
HITS-CLIP [30]
hsa-miR-200a-3p ZNF621
HITS-CLIP [30]
hsa-miR-200a-3p ANGPTL7
HITS-CLIP [30]
hsa-miR-200a-3p PRKAA2
HITS-CLIP [30]
hsa-miR-200a-3p MACC1
HITS-CLIP [30]
hsa-miR-200a-3p CCDC18
HITS-CLIP [30]
hsa-miR-200a-3p DNAJC28
HITS-CLIP [54]
hsa-miR-200a-3p ZNF292
HITS-CLIP [54]
hsa-miR-200a-3p RPL12
HITS-CLIP [54]
hsa-miR-200a-3p A1BG
HITS-CLIP [54]
hsa-miR-200a-3p POLR3F
HITS-CLIP [46]
hsa-miR-200a-3p COX6B1
HITS-CLIP [46]
hsa-miR-200a-3p RBM28
HITS-CLIP [46]
hsa-miR-200a-3p LPP
HITS-CLIP [46]
hsa-miR-200a-3p CCDC71L
HITS-CLIP [55]
hsa-miR-200a-3p TROVE2
HITS-CLIP [55]
hsa-miR-200a-3p BICRAL
HITS-CLIP [55]
hsa-miR-200a-3p ERO1A
HITS-CLIP [55]
hsa-miR-200a-3p HSPA4
HITS-CLIP [55]
hsa-miR-200a-3p SCD5
HITS-CLIP [55]
hsa-miR-200a-3p CLDND1
HITS-CLIP [55]
hsa-miR-200a-3p PEX11A
HITS-CLIP [55]
hsa-miR-200a-3p CELF1
HITS-CLIP [55]

References

authors journal year Pubmed link title
1 Itoh et al. J. Biol. Chem. 2009 19454767 MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5.
2 Iorio et al. Cancer Res. 2007 17875710 MicroRNA signatures in human ovarian cancer.
3 Hyun et al. Cell 2009 20005803 Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.
4 Murakami et al. Oncogene 2006 16331254 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.
5 Oba et al. PLoS ONE 2010 21049046 miR-200b precursor can ameliorate renal tubulointerstitial fibrosis.
6 Cong et al. Oncol. Rep. 2013 23381389 Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.
7 Xia et al. Biochem. Biophys. Res. Commun. 2010 19931509 miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion.
8 Ahmad et al. Cancer Res. 2011 21389093 Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells.
9 Truong et al. Sci Signal 2014 24518294 β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.
10 Korpal et al. J. Biol. Chem. 2008 18411277 The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.
11 Wu et al. Gynecol. Oncol. 2011 21529905 MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2.
12 Wang et al. Proc. Natl. Acad. Sci. U.S.A. 2013 23386720 Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation.
13 et al. None 21038317
14 Park et al. Genes Dev. 2008 18381893 The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
15 Santarpia et al. Endocr. Relat. Cancer 2013 24127332 A miRNA signature associated with human metastatic medullary thyroid carcinoma.
16 Saydam et al. Mol. Cell. Biol. 2009 19703993 Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway.
17 Xiong et al. Am. J. Physiol. Renal Physiol. 2012 22012804 The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression.
18 Bendoraite et al. Gynecol. Oncol. 2010 19854497 Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition.
19 Jang et al. Transl Res 2014 24280074 Loss of microRNA-200a expression correlates with tumor progression in breast cancer.
20 Gregory et al. Nat. Cell Biol. 2008 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
21 Bracken et al. Cancer Res. 2008 18829540 A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.
22 Wang et al. Am. J. Hypertens. 2010 19910931 Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis.
23 Su et al. Int. J. Oncol. 2012 22211245 MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin.
24 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
25 Sossey-Alaoui et al. J. Biol. Chem. 2009 19801681 The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.
26 Schaar et al. Exp. Hematol. 2009 19135902 miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation.
27 Wu et al. Gastroenterology 2008 18835392 MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.
28 Hildebrand et al. J. Invest. Dermatol. 2011 20827281 A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo.
29 Mateescu et al. Nat. Med. 2011 22101765 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.
30 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
31 Cai et al. Graefes Arch. Clin. Exp. Ophthalmol. 2012 22183793 MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2.
32 Xu et al. J. Cell. Sci. 2011 21914820 The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes.
33 Buller et al. Glia 2012 22907787 Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation.
34 Ahn et al. Oncogene 2012 22020340 Smad3 regulates E-cadherin via miRNA-200 pathway.
35 Yu et al. Clin. Cancer Res. 2013 23340296 MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer.
36 Cesi et al. Cell Cycle 2011 22101269 TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells.
37 Yao et al. DNA Cell Biol. 2014 24684598 microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer.
38 Lee et al. Proc. Natl. Acad. Sci. U.S.A. 2013 23784775 Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.
39 Becker et al. PLoS ONE 2012 23144891 A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways.
40 Ning et al. Cancer Lett. 2015 25595591 DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.
41 Li et al. Mol. Biol. Rep. 2014 24413994 MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN.
42 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
43 Pacurari et al. Int. J. Oncol. 2013 23708087 The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
44 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
45 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
46 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
47 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
48 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
49 Yang et al. J. Clin. Invest. 2014 24762440 ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.
50 Liu et al. PLoS ONE 2013 23874841 MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm.
51 Xiao et al. Oncol. Rep. 2013 24009066 microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6.
52 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
53 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
54 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
55 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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