miRCarta - targets

hsa-miR-106b-5p (MIMAT0000680) (1054 targets) in miRTarBase

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miRNA

gene name

experiments

hsa-miR-106b-5p

ITCH


microarray	[1]
Western blot	[2]
HITS-CLIP	[3]
Luciferase reporter assay	[4] [2]

hsa-miR-106b-5p

APP


Western blot	[5]
Luciferase reporter assay	[5]

hsa-miR-106b-5p

CDKN1A


qRT-PCR	[6] [7] [8] [9] [10] [11] [12] [13]
microarray	[14] [9] [11]
Reporter assay	[7]
Western blot	[7] [14] [8] [9] [10] [11] [12] [13]
HITS-CLIP	[3]
Luciferase reporter assay	[6] [15] [14] [9] [10] [16] [11] [12] [13]

hsa-miR-106b-5p

E2F1


qRT-PCR	[6]
microarray	[14]
Reporter assay	[12]
Western blot	[17] [14]
HITS-CLIP	[3]
Luciferase reporter assay	[6] [17] [15] [14]

hsa-miR-106b-5p

KAT2B


microarray	[1]
Western blot	[18]
Luciferase reporter assay	[18]

hsa-miR-106b-5p

VEGFA


microarray	[1]
Luciferase reporter assay	[19]
ELISA	[19]

hsa-miR-106b-5p

BCL2L11


qRT-PCR	[20]
Western blot	[20]
HITS-CLIP	[21]
Luciferase reporter assay	[20]
Flow cytometry	[20]
PAR-CLIP	[22] [23] [21] [24]

hsa-miR-106b-5p

RB1


qRT-PCR	[25]
microarray	[1] [26]
Western blot	[25]
Luciferase reporter assay	[25] [15]
PAR-CLIP	[21]
immunohistochemistry	[26]

hsa-miR-106b-5p

TCEAL1


qRT-PCR	[27] [20]
microarray	[1]
Western blot	[27] [20]
Luciferase reporter assay	[27] [28] [20]
Flow cytometry	[20]

hsa-miR-106b-5p

CCND1


HITS-CLIP	[21]
Luciferase reporter assay	[15]
PAR-CLIP	[29] [22] [23] [21] [30] [24]

Show entries

References

	authors	journal	year	Pubmed link	title
1	Linsley et al.	Mol. Cell. Biol.	2007	17242205	Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression.
2	Sampath et al.	Blood	2009	19096009	Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation.
3	Riley et al.	EMBO J.	2012	22473208	EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency.
4	Ohlsson Teague et al.	Mol. Endocrinol.	2009	19074548	MicroRNA-regulated pathways associated with endometriosis.
5	Hébert et al.	Neurobiol. Dis.	2009	19110058	MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.
6	Ambs et al.	Cancer Res.	2008	18676839	Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.
7	Wang et al.	Brain Res.	2010	20709030	miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor.
8	Yao et al.	Asian Pac. J. Cancer Prev.	2013	23803041	Effects of microRNA-106 on proliferation of gastric cancer cell through regulating p21 and E2F5.
9	Kan et al.	Gastroenterology	2009	19422085	The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim.
10	Wu et al.	Oncogene	2010	20190813	Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region.
11	Zhou et al.	Proc. Natl. Acad. Sci. U.S.A.	2010	20385818	High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2.
12	Ivanovska et al.	Mol. Cell. Biol.	2008	18212054	MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
13	Kim et al.	Nucleic Acids Res.	2009	19153141	Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer.
14	Petrocca et al.	Cancer Cell	2008	18328430	E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.
15	Trompeter et al.	PLoS ONE	2011	21283765	MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC.
16	Borgdorff et al.	Oncogene	2010	20101223	Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1).
17	Li et al.	Cancer Sci.	2009	19486339	Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma.
18	Pichiorri et al.	Proc. Natl. Acad. Sci. U.S.A.	2008	18728182	MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.
19	Ye et al.	PLoS ONE	2008	18320040	The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation.
20	Zhao et al.	PLoS ONE	2012	23028803	TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC.
21	Kishore et al.	Nat. Methods	2011	21572407	A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
22	Memczak et al.	Nature	2013	23446348	Circular RNAs are a large class of animal RNAs with regulatory potency.
23	Hafner et al.	Cell	2010	20371350	Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
24	Whisnant et al.	MBio	2013	23592263	In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
25	Cai et al.	J. Exp. Clin. Cancer Res.	2011	21819631	MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma.
26	Guo et al.	J. Gastroenterol. Hepatol.	2009	19175831	Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues.
27	Hu et al.	PLoS ONE	2011	21283757	The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.
28	Liu et al.	Cell. Physiol. Biochem.	2012	22613985	MiR-106b and MiR-15b modulate apoptosis and angiogenesis in myocardial infarction.
29	Farazi et al.	Genome Biol.	2014	24398324	Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
30	Lipchina et al.	Genes Dev.	2011	22012620	Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
31	Yang et al.	FEBS Lett.	2014	24842611	MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN.
32	Liu et al.	Oncogene	2014	24166509	MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes.
33	Zhang et al.	J. Neurooncol.	2013	23377830	Down-regulation of miR-106b suppresses the growth of human glioma cells.
34	Shen et al.	FASEB J.	2012	22835829	Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection.
35	Shen et al.	Carcinogenesis	2013	23087084	miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma.
36	Hudson et al.	Oncogene	2013	22986525	MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
37	Helwak et al.	Cell	2013	23622248	Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
38	Ye et al.	Int. J. Cancer	2015	25307786	A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide.
39	Karginov et al.	Genes Dev.	2013	23824327	Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
40	Gottwein et al.	Cell Host Microbe	2011	22100165	Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
41	Lu et al.	Gastroenterology	2014	24036151	MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy.
42	Smith et al.	Oncogene	2012	22286770	The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.
43	Yu et al.	Lab. Invest.	2014	25286029	miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells.
44	Kim et al.	Mol. Cancer Ther.	2012	22752225	Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.
45	Dong et al.	Mol. Carcinog.	2014	24002805	MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines.
46	Xue et al.	Cell	2013	23313552	Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
47	Xu et al.	FEBS Lett.	2013	23912048	MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells.
48	Ni et al.	Cancer Sci.	2014	24164962	Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2.
49	Zhang et al.	Mol. Cell. Endocrinol.	2013	23954742	MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.
50	Arabi et al.	Genes Cancer	2014	24955218	Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences.
51	Haecker et al.	PLoS Pathog.	2012	22927820	Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
52	Skalsky et al.	PLoS Pathog.	2012	22291592	The viral and cellular microRNA targetome in lymphoblastoid cell lines.
53	Chi et al.	Nature	2009	19536157	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
54	Pillai et al.	Breast Cancer Res. Treat.	2014	24906430	HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
55	Kishore et al.	Genome Biol.	2013	23706177	Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.

Targets miRBase

hsa-miR-106b-5p (MIMAT0000680) (1054 targets) in miRTarBase

References