Targets miRBase

hsa-let-7b-5p (MIMAT0000063) (1171 targets) in miRTarBase

References

authors journal year Pubmed link title
1 Mongroo et al. Cancer Res. 2011 21252116 IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
2 Johnson et al. Cancer Res. 2007 17699775 The let-7 microRNA represses cell proliferation pathways in human cells.
3 Legesse-Miller et al. J. Biol. Chem. 2009 19126550 let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.
4 Selbach et al. Nature 2008 18668040 Widespread changes in protein synthesis induced by microRNAs.
5 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
6 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
7 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
8 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
9 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
10 Cheng et al. J. Virol. 2013 23824794 High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1.
11 Schubert et al. PLoS ONE 2013 23798998 Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer.
12 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
13 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
14 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
15 Krek et al. Nat. Genet. 2005 15806104 Combinatorial microRNA target predictions.
16 Lee et al. Genes Dev. 2007 17437991 The tumor suppressor microRNA let-7 represses the HMGA2 oncogene.
17 Alajez et al. Oncotarget 2012 23482325 Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway.
18 Guo et al. Oncogene 2013 23318420 Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition.
19 Trang et al. Oncogene 2010 19966857 Regression of murine lung tumors by the let-7 microRNA.
20 Huang et al. Nat. Methods 2007 18026111 Using expression profiling data to identify human microRNA targets.
21 Zhao et al. Proc. Natl. Acad. Sci. U.S.A. 2010 20133835 MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.
22 Guo et al. J. Exp. Clin. Cancer Res. 2013 23806108 Let-7b expression determines response to chemotherapy through the regulation of cyclin D1 in glioblastoma.
23 Schultz et al. Cell Res. 2008 18379589 MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth.
24 Guo et al. Gene 2006 16971064 Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.
25 Sampson et al. Cancer Res. 2007 17942906 MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.
26 Kiriakidou et al. Genes Dev. 2004 15131085 A combined computational-experimental approach predicts human microRNA targets.
27 Witwer et al. J. Immunol. 2010 20130213 MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response.
28 Forman et al. Proc. Natl. Acad. Sci. U.S.A. 2008 18812516 A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence.
29 Nie et al. Am. J. Pathol. 2010 20651244 Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7.
30 Chen et al. PLoS ONE 2012 22761738 Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
31 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
32 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
33 Chen et al. J. Clin. Invest. 2013 23426184 Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.
34 Braun et al. Nucleic Acids Res. 2014 24510096 Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification).
35 Gao et al. Oncotarget 2014 24810113 IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma.
36 Bobbs et al. J. Biol. Chem. 2012 22995917 Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning.
37 Guo et al. PLoS ONE 2014 24978044 Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension.
38 Yu et al. Tumour Biol. 2015 25510669 Let-7b inhibits cell proliferation, migration, and invasion through targeting Cthrc1 in gastric cancer.
39 Kang et al. J Transl Med 2014 25288334 let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis.
40 Teng et al. PLoS ONE 2013 23437218 Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4.
41 Haselmann et al. Gastroenterology 2014 24120475 Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells.
42 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
43 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
44 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
45 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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