Targets miRBase

hsa-let-7a-5p (MIMAT0000062) (585 targets) in miRTarBase

References

authors journal year Pubmed link title
1 Zhang et al. DNA Cell Biol. 2014 24383407 Let-7a functions as a tumor suppressor in Ewing's sarcoma cell lines partly by targeting cyclin-dependent kinase 6.
2 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
3 Akao et al. Biol. Pharm. Bull. 2006 16651716 let-7 microRNA functions as a potential growth suppressor in human colon cancer cells.
4 Sampson et al. Cancer Res. 2007 17942906 MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.
5 He et al. J. Cancer Res. Clin. Oncol. 2010 20033209 The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
6 Braun et al. Nucleic Acids Res. 2014 24510096 Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification).
7 Garzon et al. Oncogene 2007 17260024 MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.
8 Murphy et al. J. Immunol. 2010 20351193 Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
9 Müller et al. Oncogene 2008 18679415 Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma.
10 Meng et al. J. Biol. Chem. 2007 17220301 The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.
11 Johnson et al. Cell 2005 15766527 RAS is regulated by the let-7 microRNA family.
12 Hébert et al. Neurobiol. Dis. 2009 19110058 MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.
13 Nie et al. Am. J. Pathol. 2010 20651244 Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7.
14 Nie et al. Am. J. Pathol. 2008 18583325 MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas.
15 Lee et al. J. Biol. Chem. 2005 15722555 Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.
16 Lin et al. Mol. Biol. Evol. 2007 17890240 Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development.
17 Papagiannakopoulos et al. Cancer Res. 2008 18829576 MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
18 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
19 Beitzinger et al. RNA Biol 2007 17637574 Identification of human microRNA targets from isolated argonaute protein complexes.
20 Shell et al. Proc. Natl. Acad. Sci. U.S.A. 2007 17600087 Let-7 expression defines two differentiation stages of cancer.
21 Palmieri et al. Oncogene 2012 22139073 Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis.
22 Watanabe et al. Am. J. Pathol. 2009 19179606 HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells.
23 Wei et al. Stem Cells Dev. 2014 24617339 let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2.
24 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
25 Yu et al. Cell 2007 18083101 let-7 regulates self renewal and tumorigenicity of breast cancer cells.
26 Mayr et al. Science 2007 17322030 Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation.
27 Motoyama et al. Clin. Cancer Res. 2008 18413822 Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family.
28 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
29 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
30 Takane et al. BMC Genomics 2010 20144220 Computational prediction and experimental validation of evolutionarily conserved microRNA target genes in bilaterian animals.
31 He et al. FEBS Lett. 2009 19818775 Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells.
32 Tokumaru et al. Carcinogenesis 2008 18700235 let-7 regulates Dicer expression and constitutes a negative feedback loop.
33 Mongroo et al. Cancer Res. 2011 21252116 IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
34 Wang et al. Neuro-oncology 2013 24092860 Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
35 Lu et al. Cancer Res. 2007 17974952 Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis.
36 Wu et al. Proc. Natl. Acad. Sci. U.S.A. 2006 16495412 MicroRNAs direct rapid deadenylation of mRNA.
37 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
38 Tsang et al. Apoptosis 2008 18758960 Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.
39 Iliopoulos et al. Cell 2009 19878981 An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
40 Dong et al. PLoS ONE 2010 20418948 MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.
41 De Vito et al. PLoS ONE 2011 21853155 Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma development.
42 Kim et al. Breast Cancer Res. 2012 22251626 MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7.
43 Yang et al. Cell Cycle 2012 22871741 An anti-let-7 sponge decoys and decays endogenous let-7 functions.
44 Ohno et al. Mol. Ther. 2013 23032975 Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells.
45 Bhutia et al. PLoS ONE 2013 23335963 Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.
46 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
47 Chen et al. J. Clin. Invest. 2013 23426184 Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.
48 Cai et al. Oncol. Rep. 2012 22972404 Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells.
49 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
50 Hu et al. Mol. Cancer Res. 2013 23339187 The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer.
51 Liu et al. FEBS Lett. 2013 23769985 Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B.
52 Yang et al. Carcinogenesis 2011 21349817 Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C.
53 Ustianenko et al. RNA 2013 24141620 Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.
54 Haselmann et al. Gastroenterology 2014 24120475 Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells.
55 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
56 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
57 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
58 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
59 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
60 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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