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mmu-miR-21a-5p (MIMAT0000530) (29 targets) in miRTarBase

miRNA gene name experiments
mmu-miR-21a-5p Fasl
Northern blot [1]
Reporter assay [1]
Western blot [1]
Other [1]
Luciferase reporter assay [1]
mmu-miR-21a-5p Peli1
qRT-PCR [2]
Reporter assay [2]
Other [2]
Luciferase reporter assay [2]
mmu-miR-21a-5p Pdcd4
qRT-PCR [3] [4] [5]
Western blot [6] [3] [1]
Luciferase reporter assay [3] [6]
ELISA [3]
mmu-miR-21a-5p Spry2
Reporter assay [7]
Western blot [7]
Other [7]
Luciferase reporter assay [7]
mmu-miR-21a-5p Pten
Reporter assay [2]
Western blot [8]
Luciferase reporter assay [8]
mmu-miR-21a-5p Reck
qRT-PCR [5]
Western blot [6] [7]
Luciferase reporter assay [9]
mmu-miR-21a-5p Spry1
Western blot [10] [7] [11]
Luciferase reporter assay [10] [11]
mmu-miR-21a-5p Tgfbi
qRT-PCR [12]
Western blot [12]
Luciferase reporter assay [12]
ELISA [12]
FACS [12]
mmu-miR-21a-5p Spry4
qRT-PCR [10]
mmu-miR-21a-5p Spry3
Western blot [7] [8]
mmu-miR-21a-5p Tnfaip8l2
qRT-PCR [13]
ChIP [13]
Western blot [13]
Luciferase reporter assay [13]
Flow cytometry [13]
mmu-miR-21a-5p Smad7
Northern blot [14]
qRT-PCR [14]
Luciferase reporter assay [14]
Immunoprecipitation [14]
mmu-miR-21a-5p Gt(ROSA)26Sor
qRT-PCR [15]
Luciferase reporter assay [15]
Immunohistochemistry [15]
Southern blot [15]
mmu-miR-21a-5p Yy1
qRT-PCR [16]
Luciferase reporter assay [16]
mmu-miR-21a-5p Eif4e3
qRT-PCR [16]
Luciferase reporter assay [16]
mmu-miR-21a-5p Pdcd10
qRT-PCR [16]
Luciferase reporter assay [16]
mmu-miR-21a-5p Timp3
qRT-PCR [17]
mmu-miR-21a-5p Mmp9
qRT-PCR [18]
In situ hybridization [18]
Western blot [18]
Immunohistochemistry [18]
mmu-miR-21a-5p Kcnk6
HITS-CLIP [19]
mmu-miR-21a-5p Map3k1
HITS-CLIP [19]
mmu-miR-21a-5p Cyfip1
HITS-CLIP [19]
mmu-miR-21a-5p Rmnd5a
HITS-CLIP [20]
mmu-miR-21a-5p Tns1
HITS-CLIP [21]
mmu-miR-21a-5p Gid4
HITS-CLIP [21]
mmu-miR-21a-5p E2f2
HITS-CLIP [21]
mmu-miR-21a-5p Rpp40
HITS-CLIP [22]
mmu-miR-21a-5p Moap1
HITS-CLIP [22]
mmu-miR-21a-5p Gon7
HITS-CLIP [22]
mmu-miR-21a-5p PDCD4
qRT-PCR [23]

References

authors journal year Pubmed link title
1 Sayed et al. J. Biol. Chem. 2010 20404348 MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand.
2 Marquez et al. Am. J. Physiol. Gastrointest. Liver Physiol. 2010 20167875 MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling.
3 Luo et al. BMC Syst Biol 2014 25000828 Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine.
4 Sugatani et al. Blood 2011 21273303 A microRNA expression signature of osteoclastogenesis.
5 Hayashi et al. Dev. Biol. 2011 21295561 Mesenchymal miR-21 regulates branching morphogenesis in murine submandibular gland in vitro.
6 Lu et al. Oncogene 2008 18372920 MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.
7 Sayed et al. Mol. Biol. Cell 2008 18508928 MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.
8 Roy et al. Cardiovasc. Res. 2009 19147652 MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.
9 Hu et al. J. Biol. Chem. 2008 18556655 MicroRNA expression and regulation in mouse uterus during embryo implantation.
10 Thum et al. Nature 2008 19043405 MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
11 Inui et al. Nat. Rev. Mol. Cell Biol. 2010 20216554 MicroRNA control of signal transduction.
12 Liu et al. Int. J. Biol. Sci. 2011 21494432 MiR-21 plays an important role in radiation induced carcinogenesis in BALB/c mice by directly targeting the tumor suppressor gene Big-h3.
13 Ruan et al. Cell Death Dis 2014 24577093 MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2.
14 Li et al. Sci Rep 2013 23784029 MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation.
15 Bhalala et al. J. Neurosci. 2012 23238710 microRNA-21 regulates astrocytic response following spinal cord injury.
16 Soares et al. J. Biol. Chem. 2014 24891504 Involvement of microRNAs in the regulation of muscle wasting during catabolic conditions.
17 Fiorentino et al. Acta Diabetol 2013 23797704 Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs.
18 Wang et al. Cell Biochem. Biophys. 2013 23443810 Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice.
19 Zhang et al. Cell 2014 25083871 MicroRNA directly enhances mitochondrial translation during muscle differentiation.
20 Schug et al. BMC Genomics 2013 23597149 Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver.
21 Loeb et al. Mol. Cell 2012 23142080 Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting.
22 Leung et al. Nat. Struct. Mol. Biol. 2011 21258322 Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.
23 Shen et al. J Cancer 2014 25520758 MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma.
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