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hsa-miR-143-3p (MIMAT0000435) (152 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-143-3p KRAS
qRT-PCR [1] [2] [3]
microarray [2]
Western blot [1] [3] [4]
Luciferase reporter assay [2] [1]
hsa-miR-143-3p MYO6
qRT-PCR [5]
Western blot [5] [6]
Luciferase reporter assay [5]
hsa-miR-143-3p DNMT3A
qRT-PCR [7] [8]
Western blot [7] [8]
Luciferase reporter assay [7] [8]
hsa-miR-143-3p FNDC3B
qRT-PCR [9]
Western blot [9]
Luciferase reporter assay [9]
hsa-miR-143-3p COX2
microarray [10]
hsa-miR-143-3p HRAS
Northern blot [11]
qRT-PCR [11]
Luciferase reporter assay [11]
hsa-miR-143-3p HK2
qRT-PCR [12]
Western blot [12]
Luciferase reporter assay [13] [14] [15] [16] [12]
hsa-miR-143-3p SERPINE1
qRT-PCR [17]
Western blot [17]
Immunoblot [17]
Luciferase reporter assay [17]
hsa-miR-143-3p FHIT
Luciferase reporter assay [18]
hsa-miR-143-3p MACC1
qRT-PCR [19]
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-143-3p PTGS2
qRT-PCR [20]
Western blot [20]
Luciferase reporter assay [21] [20]
hsa-miR-143-3p AKT1
qRT-PCR [22]
Western blot [22]
Luciferase reporter assay [22]
hsa-miR-143-3p MDM2
Luciferase reporter assay [23]
hsa-miR-143-3p BCL2
qRT-PCR [24] [25]
microarray [24]
Immunofluorescence [25]
Western blot [24] [25] [4] [6]
Luciferase reporter assay [25] [24]
Immunohistochemistry [25]
hsa-miR-143-3p MMP13
microarray [26]
Western blot [26]
Luciferase reporter assay [27]
hsa-miR-143-3p SDC1
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-143-3p RREB1
qRT-PCR [29]
Western blot [29]
Luciferase reporter assay [29]
Immunohistochemistry [29]
hsa-miR-143-3p CD44
qRT-PCR [1]
Western blot [1]
Luciferase reporter assay [1]
hsa-miR-143-3p KLF5
qRT-PCR [1]
Western blot [1]
Luciferase reporter assay [1]
hsa-miR-143-3p BRAF
qRT-PCR [1]
Western blot [1]
Luciferase reporter assay [1]
hsa-miR-143-3p MAP3K7
microarray [30]
hsa-miR-143-3p CHST10
microarray [30]
hsa-miR-143-3p MAPK1
microarray [30]
PAR-CLIP [31] [32]
hsa-miR-143-3p COL5A1
microarray [30]
hsa-miR-143-3p PDGFRA
microarray [30]
hsa-miR-143-3p SMAD3
microarray [30]
hsa-miR-143-3p CTNND1
microarray [30]
hsa-miR-143-3p COL5A2
microarray [30]
hsa-miR-143-3p ERBB3
microarray [30]
hsa-miR-143-3p IGF1R
qRT-PCR [25]
Immunofluorescence [25]
LacZ reporter assay [25]
Western blot [25]
Immunohistochemistry [25]
hsa-miR-143-3p RAB22A
PAR-CLIP [33] [32]
hsa-miR-143-3p RBM27
PAR-CLIP [32] [33]
hsa-miR-143-3p USP42
PAR-CLIP [31] [34] [32]
hsa-miR-143-3p CMPK1
PAR-CLIP [31]
hsa-miR-143-3p SAMD8
PAR-CLIP [31]
hsa-miR-143-3p BTF3L4
PAR-CLIP [34] [32]
hsa-miR-143-3p KAT7
PAR-CLIP [33]
hsa-miR-143-3p ZNF264
PAR-CLIP [34] [32]
hsa-miR-143-3p CALM3
PAR-CLIP [31]
hsa-miR-143-3p PRRC2B
PAR-CLIP [33]
hsa-miR-143-3p ORAI2
HITS-CLIP [32]
hsa-miR-143-3p TNF
qRT-PCR [35]
Luciferase reporter assay [35]
hsa-miR-143-3p NR2C2
qRT-PCR [20]
Western blot [20]
Luciferase reporter assay [20]
hsa-miR-143-3p IL13RA1
qRT-PCR [36]
Western blot [36]
hsa-miR-143-3p COL3A1
qRT-PCR [37]
In situ hybridization [37]
Western blot [37]
hsa-miR-143-3p DDX6
qRT-PCR [38]
Immunofluorescence [38]
Western blot [38]
Luciferase reporter assay [38]
hsa-miR-143-3p LIMK1
Western blot [39]
Luciferase reporter assay [39]
hsa-miR-143-3p HNF4A
Luciferase reporter assay [40]
hsa-miR-143-3p CASP5
PAR-CLIP [41]
hsa-miR-143-3p LRIT3
PAR-CLIP [41]
hsa-miR-143-3p NAPEPLD
PAR-CLIP [41]
hsa-miR-143-3p PAPPA
PAR-CLIP [41]
hsa-miR-143-3p VOPP1
PAR-CLIP [41]
hsa-miR-143-3p FAM120AOS
PAR-CLIP [41]
hsa-miR-143-3p C1orf61
PAR-CLIP [41]
hsa-miR-143-3p PGLS
PAR-CLIP [41]
hsa-miR-143-3p YARS
PAR-CLIP [33]
hsa-miR-143-3p HAAO
PAR-CLIP [33]
hsa-miR-143-3p SYT7
PAR-CLIP [33]
hsa-miR-143-3p ZC3HAV1L
PAR-CLIP [33]
hsa-miR-143-3p UCK2
PAR-CLIP [33]
hsa-miR-143-3p TAF1D
HITS-CLIP [42]
PAR-CLIP [33]
hsa-miR-143-3p SLC2A14
PAR-CLIP [33]
hsa-miR-143-3p SLC25A25
PAR-CLIP [33]
hsa-miR-143-3p SGPL1
PAR-CLIP [33]
hsa-miR-143-3p SECISBP2L
PAR-CLIP [33] [34] [32]
hsa-miR-143-3p RER1
PAR-CLIP [33]
hsa-miR-143-3p PPP2R5E
PAR-CLIP [33]
hsa-miR-143-3p NFIC
PAR-CLIP [33]
hsa-miR-143-3p NCKAP1
PAR-CLIP [33]
hsa-miR-143-3p KLK10
PAR-CLIP [33]
hsa-miR-143-3p GXYLT1
PAR-CLIP [33] [43]
hsa-miR-143-3p CSRNP2
PAR-CLIP [33]
hsa-miR-143-3p BBC3
PAR-CLIP [33] [43]
hsa-miR-143-3p TFPI
PAR-CLIP [33]
hsa-miR-143-3p GLRA3
PAR-CLIP [33]
hsa-miR-143-3p PLEKHM3
PAR-CLIP [33]
hsa-miR-143-3p ZNF607
PAR-CLIP [44]
hsa-miR-143-3p TUBB2A
PAR-CLIP [34] [32] [43]
hsa-miR-143-3p ENO4
PAR-CLIP [31]
hsa-miR-143-3p DBT
PAR-CLIP [31]
hsa-miR-143-3p ADAMTS4
HITS-CLIP [45]
PAR-CLIP [31]
hsa-miR-143-3p OR7D2
PAR-CLIP [31]
hsa-miR-143-3p SPTLC2
PAR-CLIP [31]
hsa-miR-143-3p XIAP
HITS-CLIP [45]
PAR-CLIP [31]
hsa-miR-143-3p PHAX
PAR-CLIP [31] [34]
hsa-miR-143-3p RPS27
PAR-CLIP [34] [32] [46]
hsa-miR-143-3p YWHAB
HITS-CLIP [32]
PAR-CLIP [46]
hsa-miR-143-3p GGA2
PAR-CLIP [46]
hsa-miR-143-3p ZBTB44
HITS-CLIP [47]
PAR-CLIP [32]
hsa-miR-143-3p STOX2
PAR-CLIP [34] [32]
hsa-miR-143-3p NFYB
PAR-CLIP [32]
hsa-miR-143-3p IGFBP5
PAR-CLIP [34]
hsa-miR-143-3p IER5
PAR-CLIP [34]
hsa-miR-143-3p COMMD2
PAR-CLIP [34]
hsa-miR-143-3p CENPP
PAR-CLIP [34]
hsa-miR-143-3p ZNF277
PAR-CLIP [34]
hsa-miR-143-3p SLC30A9
PAR-CLIP [34]
hsa-miR-143-3p NUDT3
HITS-CLIP [45]
hsa-miR-143-3p OAS3
HITS-CLIP [45]
hsa-miR-143-3p GALNT6
HITS-CLIP [45]
hsa-miR-143-3p TTC38
HITS-CLIP [45]
hsa-miR-143-3p LRAT
HITS-CLIP [45] [48]
hsa-miR-143-3p ADH5
HITS-CLIP [45]
hsa-miR-143-3p SLC25A33
HITS-CLIP [45]
hsa-miR-143-3p FAXC
HITS-CLIP [45] [32]
hsa-miR-143-3p NUBPL
HITS-CLIP [45]
hsa-miR-143-3p SCN2B
HITS-CLIP [45]
hsa-miR-143-3p CERS4
HITS-CLIP [45]
hsa-miR-143-3p HYPK
HITS-CLIP [45]
hsa-miR-143-3p TRIM71
HITS-CLIP [45]
hsa-miR-143-3p TIMM8A
HITS-CLIP [45]
hsa-miR-143-3p CREG2
HITS-CLIP [45]
hsa-miR-143-3p C2orf15
HITS-CLIP [45]
hsa-miR-143-3p SKAP2
HITS-CLIP [45]
hsa-miR-143-3p ELP2
HITS-CLIP [45]
hsa-miR-143-3p ZNF573
HITS-CLIP [45]
hsa-miR-143-3p ANKRD9
HITS-CLIP [45]
hsa-miR-143-3p FAM71F2
HITS-CLIP [45]
hsa-miR-143-3p ZNF429
HITS-CLIP [45]
hsa-miR-143-3p IKZF3
HITS-CLIP [45]
hsa-miR-143-3p KIAA0930
HITS-CLIP [45]
hsa-miR-143-3p SLC25A16
HITS-CLIP [45] [48]
hsa-miR-143-3p GTF2H5
HITS-CLIP [45]
hsa-miR-143-3p UBE2V2
HITS-CLIP [45]
hsa-miR-143-3p LRRC2
HITS-CLIP [45]
hsa-miR-143-3p C1orf50
HITS-CLIP [45]
hsa-miR-143-3p RUNDC1
HITS-CLIP [45]
hsa-miR-143-3p THAP1
HITS-CLIP [45]
hsa-miR-143-3p SLC35F6
HITS-CLIP [45]
hsa-miR-143-3p ZNF440
HITS-CLIP [45]
hsa-miR-143-3p DCTN6
HITS-CLIP [45]
hsa-miR-143-3p PLEKHA1
HITS-CLIP [45]
hsa-miR-143-3p MYCBP
HITS-CLIP [45]
hsa-miR-143-3p PRR23A
HITS-CLIP [45]
hsa-miR-143-3p NPR1
HITS-CLIP [45]
hsa-miR-143-3p FGD6
HITS-CLIP [45]
hsa-miR-143-3p CCR6
HITS-CLIP [45]
hsa-miR-143-3p FSD2
HITS-CLIP [45]
hsa-miR-143-3p IL10RB
HITS-CLIP [45]
hsa-miR-143-3p MYPN
HITS-CLIP [42]
hsa-miR-143-3p RPS19
HITS-CLIP [47]
hsa-miR-143-3p PPIL4
HITS-CLIP [47]
hsa-miR-143-3p SFT2D2
HITS-CLIP [47]
hsa-miR-143-3p RAB33B
HITS-CLIP [47]
hsa-miR-143-3p MIER3
HITS-CLIP [47]
hsa-miR-143-3p ACOT9
HITS-CLIP [48]
hsa-miR-143-3p GJD2
HITS-CLIP [48]
hsa-miR-143-3p RRP7A
HITS-CLIP [32]
hsa-miR-143-3p GLUL
HITS-CLIP [49]
hsa-miR-143-3p PNPO
HITS-CLIP [49]
hsa-miR-143-3p ABAT
HITS-CLIP [49]

References

authors journal year Pubmed link title
1 Pagliuca et al. Oncogene 2013 23128394 Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression.
2 Chen et al. Oncogene 2009 19137007 Role of miR-143 targeting KRAS in colorectal tumorigenesis.
3 Lin et al. J. Urol. 2009 19157460 MicroRNA-143 as a tumor suppressor for bladder cancer.
4 Ni et al. Gene 2013 23276710 MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma.
5 Szczyrba et al. Mol. Cancer Res. 2010 20353999 The microRNA profile of prostate carcinoma obtained by deep sequencing.
6 Borralho et al. FEBS J. 2009 19843160 MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.
7 Ng et al. Br. J. Cancer 2009 19638978 MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer.
8 Ng et al. Tumour Biol. 2014 24218337 MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.
9 Zhang et al. Hepatology 2009 19472311 Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression.
10 Iorio et al. Cancer Res. 2007 17875710 MicroRNA signatures in human ovarian cancer.
11 Gao et al. FEBS Lett. 2011 21276449 The Evi1, microRNA-143, K-Ras axis in colon cancer.
12 Yoshino et al. Cancer Sci. 2013 24033605 Tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
13 Jiang et al. EMBO J. 2012 22354042 A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.
14 Fang et al. J. Biol. Chem. 2012 22593586 MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.
15 Gregersen et al. BMC Cancer 2012 22691140 MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells.
16 Zhao et al. Cancer Lett. 2013 23376635 miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
17 Villadsen et al. Br. J. Cancer 2012 22108519 The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer.
18 Lin et al. Cancer Biother. Radiopharm. 2011 21711110 microRNA-143 protects cells from DNA damage-induced killing by downregulating FHIT expression.
19 Zhang et al. Mol. Cancer 2012 22533346 MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer.
20 Zhao et al. Stem Cells 2014 24105952 The toll-like receptor 3 ligand, poly(I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143.
21 Song et al. Asian Pac. J. Cancer Prev. 2011 21790228 Expression of miR-143 reduces growth and migration of human bladder carcinoma cells by targeting cyclooxygenase-2.
22 Noguchi et al. Cancer Lett. 2013 23104321 Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways.
23 Zhang et al. Oncogene 2013 22330136 Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
24 Liu et al. Mol Med Rep 2012 22160209 miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2.
25 Zhuang et al. Tumour Biol. 2015 25492481 Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2.
26 Osaki et al. Mol. Ther. 2011 21427707 MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression.
27 Wu et al. Mol Med Rep 2013 23732700 MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer.
28 Li et al. PLoS ONE 2014 24722758 MicroRNA-143 targets Syndecan-1 to repress cell growth in melanoma.
29 Kent et al. Oncogene 2013 22751122 RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets.
30 Bakhshandeh et al. J. Genet. 2012 22942087 A microRNA signature associated with chondrogenic lineage commitment.
31 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
32 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
33 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
34 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
35 Kopp et al. Gene Ther. 2013 23804075 De-targeting by miR-143 decreases unwanted transgene expression in non-tumorigenic cells.
36 Yu et al. Int J Mol Sci 2013 23965966 MicroRNA-143 downregulates interleukin-13 receptor alpha1 in human mast cells.
37 Naito et al. Cancer Sci. 2014 24283360 MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer.
38 Iio et al. Biochim. Biophys. Acta 2013 23932921 DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells.
39 Xia et al. Int J Mol Sci 2014 25003638 miR-143 inhibits NSCLC cell growth and metastasis by targeting Limk1.
40 Wang et al. Biochim. Biophys. Acta 2013 23298640 The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation.
41 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
42 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
43 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
44 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
45 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
46 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
47 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
48 Haecker et al. PLoS Pathog. 2012 22927820 Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
49 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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