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hsa-miR-138-5p (MIMAT0000430) (93 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-138-5p ROCK2
qRT-PCR [1]
Reporter assay [1]
Western blot [1]
Other [1]
Luciferase reporter assay [1]
hsa-miR-138-5p RHOC
qRT-PCR [2] [1]
Reporter assay [1]
Western blot [1]
Luciferase reporter assay [1] [3]
PAR-CLIP [4]
hsa-miR-138-5p TERT
qRT-PCR [5]
Reporter assay [5]
Western blot [5]
Other [5]
Luciferase reporter assay [5]
hsa-miR-138-5p EID1
qRT-PCR [6]
Western blot [6]
Luciferase reporter assay [6]
Quantitative proteomic approach [6]
hsa-miR-138-5p CEBPA
qRT-PCR [6]
hsa-miR-138-5p PPARG
qRT-PCR [6]
hsa-miR-138-5p FABP4
qRT-PCR [6]
hsa-miR-138-5p LPL
qRT-PCR [6]
hsa-miR-138-5p GNAI2
qRT-PCR [7]
microarray [7]
Western blot [7]
hsa-miR-138-5p FOSL1
Western blot [8]
Luciferase reporter assay [8]
hsa-miR-138-5p SIRT1
Luciferase reporter assay [9]
hsa-miR-138-5p CCND3
qRT-PCR [10] [11] [12]
Western blot [10]
Immunoblot [11]
Luciferase reporter assay [11] [10]
hsa-miR-138-5p PTK2
Western blot [13]
Luciferase reporter assay [13]
hsa-miR-138-5p H2AFX
Western blot [14]
Luciferase reporter assay [14]
PAR-CLIP [15] [16]
hsa-miR-138-5p HIF1A
Luciferase reporter assay [17] [18]
hsa-miR-138-5p CASP3
Luciferase reporter assay [19]
hsa-miR-138-5p BLCAP
microarray [19]
Luciferase reporter assay [19]
hsa-miR-138-5p MXD1
microarray [19]
Luciferase reporter assay [19]
hsa-miR-138-5p RELN
Luciferase reporter assay [20]
hsa-miR-138-5p EZH2
qRT-PCR [2] [21] [22]
Reporter assay [2]
Western blot [2] [21] [22]
Other [2]
Immunoblot [23]
Luciferase reporter assay [23] [21] [22]
Immunohistochemistry [22]
ELISA [23]
hsa-miR-138-5p SOX4
Luciferase reporter assay [18]
hsa-miR-138-5p MMP3
qRT-PCR [2]
hsa-miR-138-5p CDH2
qRT-PCR [2]
hsa-miR-138-5p PLEK2
qRT-PCR [2]
hsa-miR-138-5p CDH1
Western blot [2]
hsa-miR-138-5p SNAI2
qRT-PCR [2]
Western blot [2]
hsa-miR-138-5p SERPINE1
qRT-PCR [2]
hsa-miR-138-5p SUZ12
qRT-PCR [2]
Western blot [2]
hsa-miR-138-5p ZEB2
qRT-PCR [2]
Reporter assay [2]
hsa-miR-138-5p VIM
qRT-PCR [2] [24]
Reporter assay [2]
Western blot [2] [24]
Other [2]
hsa-miR-138-5p PHKG2
CLASH [25]
hsa-miR-138-5p PPP1R13B
CLASH [25]
hsa-miR-138-5p RARA
CLASH [25]
hsa-miR-138-5p RGS12
CLASH [25]
hsa-miR-138-5p TOR2A
CLASH [25]
hsa-miR-138-5p AGO1
CLASH [25]
hsa-miR-138-5p NVL
CLASH [25]
hsa-miR-138-5p DMKN
CLASH [25]
hsa-miR-138-5p HIST1H2BK
CLASH [25]
hsa-miR-138-5p HIST1H2BJ
CLASH [25]
hsa-miR-138-5p S100A1
Immunoblot [26]
Luciferase reporter assay [26]
hsa-miR-138-5p CCND1
qRT-PCR [27]
microarray [27]
Western blot [27]
Luciferase reporter assay [27]
Immunohistochemistry [27]
hsa-miR-138-5p SENP1
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-138-5p ADGRA2
qRT-PCR [29]
microarray [29]
Western blot [29]
Luciferase reporter assay [29]
Immunohistochemistry [29]
hsa-miR-138-5p RMND5A
qRT-PCR [30]
microarray [30]
Immunofluorescence [30]
Western blot [30]
Luciferase reporter assay [30]
Immunoprecipitaion [30]
hsa-miR-138-5p IGF2BP1
PAR-CLIP [4] [15] [16]
hsa-miR-138-5p CBY1
PAR-CLIP [16] [4]
hsa-miR-138-5p HMGA1
PAR-CLIP [31]
hsa-miR-138-5p ZMYND11
PAR-CLIP [16]
hsa-miR-138-5p DNAJB6
PAR-CLIP [15] [16] [4]
hsa-miR-138-5p ARHGAP42
PAR-CLIP [15] [4]
hsa-miR-138-5p TWIST2
Luciferase reporter assay [32]
hsa-miR-138-5p MAP3K11
Luciferase reporter assay [33]
hsa-miR-138-5p LCN2
qRT-PCR [34]
Western blot [34]
Luciferase reporter assay [34]
hsa-miR-138-5p C16orf87
PAR-CLIP [35]
hsa-miR-138-5p TRAM1
PAR-CLIP [36]
hsa-miR-138-5p CSRP2
PAR-CLIP [4] [36]
hsa-miR-138-5p ZNF607
PAR-CLIP [36]
hsa-miR-138-5p CST9
PAR-CLIP [36]
hsa-miR-138-5p TSTD2
PAR-CLIP [36]
hsa-miR-138-5p IL10RA
PAR-CLIP [36]
hsa-miR-138-5p MEX3A
PAR-CLIP [36]
hsa-miR-138-5p SEMA4C
PAR-CLIP [15] [16] [37]
hsa-miR-138-5p FERMT2
PAR-CLIP [15]
hsa-miR-138-5p FEM1B
PAR-CLIP [15]
hsa-miR-138-5p C12orf49
PAR-CLIP [15] [16]
hsa-miR-138-5p PFN2
PAR-CLIP [16] [4] [15]
hsa-miR-138-5p LNPEP
PAR-CLIP [15] [16]
hsa-miR-138-5p DEK
PAR-CLIP [15] [16] [4]
hsa-miR-138-5p TP53INP2
PAR-CLIP [15]
hsa-miR-138-5p ARL5B
PAR-CLIP [15] [16]
hsa-miR-138-5p C7orf33
PAR-CLIP [31] [16]
hsa-miR-138-5p PLEKHG4B
PAR-CLIP [31]
hsa-miR-138-5p MYO3A
PAR-CLIP [31]
hsa-miR-138-5p LIN52
PAR-CLIP [4]
hsa-miR-138-5p BAG4
PAR-CLIP [4]
hsa-miR-138-5p FAM35A
PAR-CLIP [16]
hsa-miR-138-5p UBE2V1
PAR-CLIP [16]
hsa-miR-138-5p TMEM189-UBE2V1
PAR-CLIP [16]
hsa-miR-138-5p TMEM189
PAR-CLIP [16]
hsa-miR-138-5p IGLON5
HITS-CLIP [38] [39]
hsa-miR-138-5p GRID1
HITS-CLIP [38]
hsa-miR-138-5p PPM1D
HITS-CLIP [38]
hsa-miR-138-5p FUT11
HITS-CLIP [38]
hsa-miR-138-5p PPM1L
HITS-CLIP [38]
hsa-miR-138-5p CAPN7
HITS-CLIP [38]
hsa-miR-138-5p ZNF426
HITS-CLIP [40]
hsa-miR-138-5p PLAGL2
HITS-CLIP [40]
hsa-miR-138-5p NR3C1
HITS-CLIP [40]
hsa-miR-138-5p MEAF6
HITS-CLIP [40]
hsa-miR-138-5p KCNK12
HITS-CLIP [4]
hsa-miR-138-5p MTHFD1L
HITS-CLIP [41]
hsa-miR-138-5p NEUROD1
HITS-CLIP [41]

References

authors journal year Pubmed link title
1 Jiang et al. Int. J. Cancer 2010 20232393 Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
2 Liu et al. Biochem. J. 2011 21770894 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines.
3 Jin et al. Methods Mol. Biol. 2013 23007504 Evaluating the microRNA targeting sites by luciferase reporter gene assay.
4 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
5 Mitomo et al. Cancer Sci. 2008 18201269 Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines.
6 Yang et al. Stem Cells Dev. 2011 20486779 MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1.
7 Jiang et al. Hum. Genet. 2011 21079996 Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma.
8 Jin et al. J. Biol. Chem. 2011 21969367 Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma.
9 Rivetti di Val Cervo et al. Proc. Natl. Acad. Sci. U.S.A. 2012 22228303 p63-microRNA feedback in keratinocyte senescence.
10 Wang et al. Carcinogenesis 2012 22362728 MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma.
11 Xu et al. Oncogene 2014 23208504 BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia.
12 Huang et al. J. Surg. Res. 2015 25439221 Clinical significance of microRNA 138 and cyclin D3 in hepatocellular carcinoma.
13 Eskildsen et al. Proc. Natl. Acad. Sci. U.S.A. 2011 21444814 MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo.
14 Wang et al. Mol. Cancer Res. 2011 21693595 MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
15 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
16 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
17 Song et al. Asian Pac. J. Cancer Prev. 2011 21875287 MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells.
18 Yeh et al. Int. J. Cancer 2013 23389731 MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.
19 Chan et al. Cell Rep 2012 22921398 Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas.
20 Kisliouk et al. Neuroscience 2013 23438760 MiR-138 promotes the migration of cultured chicken embryonic hypothalamic cells by targeting reelin.
21 Zhang et al. Cell. Physiol. Biochem. 2013 23343715 MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer.
22 Qiu et al. Biochim. Biophys. Acta 2013 23707559 Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme.
23 Bockhorn et al. Cancer Res. 2014 25339353 Differentiation and loss of malignant character of spontaneous pulmonary metastases in patient-derived breast cancer models.
24 Yamasaki et al. Int. J. Oncol. 2012 22766839 Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma.
25 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
26 Sen et al. PLoS ONE 2013 24244340 MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.
27 Liu et al. Cell Cycle 2012 22739938 MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene.
28 Yang et al. Tumour Biol. 2014 24691972 Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells.
29 Gao et al. Biochem. Biophys. Res. Commun. 2014 24582749 miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124.
30 Li et al. Nucleic Acids Res. 2014 24057215 MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability.
31 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
32 Long et al. J Transl Med 2013 24171926 Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2.
33 He et al. Biochem. Biophys. Res. Commun. 2013 24211202 miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway.
34 Lee et al. PLoS ONE 2012 23300839 MicroRNA-138 suppresses neutrophil gelatinase-associated lipocalin expression and inhibits tumorigenicity.
35 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
36 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
37 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
38 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
39 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
40 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
41 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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