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hsa-miR-135a-5p (MIMAT0000428) (71 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-135a-5p JAK2
qRT-PCR [1]
Western blot [1] [2]
Luciferase reporter assay [2]
hsa-miR-135a-5p NR3C2
qRT-PCR [3]
Luciferase reporter assay [3]
hsa-miR-135a-5p APC
qRT-PCR [4]
Luciferase reporter assay [4]
hsa-miR-135a-5p HOXA10
qRT-PCR [5]
Western blot [5]
Luciferase reporter assay [6] [5]
hsa-miR-135a-5p MYC
Western blot [7]
HITS-CLIP [8]
Luciferase reporter assay [7]
PAR-CLIP [8] [9] [10]
hsa-miR-135a-5p SMAD5
qRT-PCR [11]
Western blot [11]
Luciferase reporter assay [11]
hsa-miR-135a-5p BMPR2
qRT-PCR [11]
Western blot [11]
Luciferase reporter assay [11]
hsa-miR-135a-5p STAT6
qRT-PCR [11]
Western blot [11]
Luciferase reporter assay [11]
hsa-miR-135a-5p MTSS1
qRT-PCR [12]
Western blot [12]
Luciferase reporter assay [12]
hsa-miR-135a-5p ROCK1
qRT-PCR [13]
Western blot [13]
Luciferase reporter assay [13]
Immunohistochemistry [13]
hsa-miR-135a-5p VLDLR
qRT-PCR [14]
Western blot [14]
Luciferase reporter assay [14]
hsa-miR-135a-5p TXNIP
PAR-CLIP [15] [10] [8] [9]
hsa-miR-135a-5p PIP5K1A
PAR-CLIP [16]
hsa-miR-135a-5p BIRC5
PAR-CLIP [15] [10] [8]
hsa-miR-135a-5p IRS2
Luciferase reporter assay [17]
hsa-miR-135a-5p HTR1A
Luciferase reporter assay [18]
hsa-miR-135a-5p SLC6A4
Luciferase reporter assay [18]
hsa-miR-135a-5p SIAH1
Luciferase reporter assay [19]
hsa-miR-135a-5p BCL2
qRT-PCR [20]
Luciferase reporter assay [20]
hsa-miR-135a-5p VNN3
PAR-CLIP [16]
hsa-miR-135a-5p GAGE1
PAR-CLIP [16]
hsa-miR-135a-5p KIF6
PAR-CLIP [16]
hsa-miR-135a-5p TTLL7
PAR-CLIP [16]
hsa-miR-135a-5p PCP4L1
PAR-CLIP [16]
hsa-miR-135a-5p TOX4
PAR-CLIP [16]
hsa-miR-135a-5p APOA1
PAR-CLIP [16]
hsa-miR-135a-5p CDR1
PAR-CLIP [16]
hsa-miR-135a-5p IL17RA
PAR-CLIP [16]
hsa-miR-135a-5p NUFIP2
PAR-CLIP [21]
hsa-miR-135a-5p KIAA1958
PAR-CLIP [22]
hsa-miR-135a-5p GATA6
PAR-CLIP [23] [22]
hsa-miR-135a-5p XBP1P1
PAR-CLIP [8] [9] [15] [10]
hsa-miR-135a-5p NHS
PAR-CLIP [15]
hsa-miR-135a-5p MARCKS
HITS-CLIP [8]
PAR-CLIP [15] [8]
hsa-miR-135a-5p ZNF805
PAR-CLIP [15]
hsa-miR-135a-5p TRIM4
PAR-CLIP [10] [23]
hsa-miR-135a-5p GNL1
PAR-CLIP [23]
hsa-miR-135a-5p DPP8
PAR-CLIP [23]
hsa-miR-135a-5p HEYL
PAR-CLIP [8]
hsa-miR-135a-5p SLC39A6
PAR-CLIP [8]
hsa-miR-135a-5p ARC
PAR-CLIP [8]
hsa-miR-135a-5p KIAA1143
PAR-CLIP [10] [8]
hsa-miR-135a-5p HMGB2
PAR-CLIP [10]
hsa-miR-135a-5p CAPZA2
PAR-CLIP [10]
hsa-miR-135a-5p ZNF107
HITS-CLIP [24]
PAR-CLIP [10]
hsa-miR-135a-5p ZNF468
PAR-CLIP [10]
hsa-miR-135a-5p ZNF846
PAR-CLIP [10]
hsa-miR-135a-5p CCDC85C
HITS-CLIP [25] [26]
hsa-miR-135a-5p SCYL3
HITS-CLIP [26]
hsa-miR-135a-5p ST8SIA4
HITS-CLIP [26]
hsa-miR-135a-5p TNPO2
HITS-CLIP [26]
hsa-miR-135a-5p PIAS4
HITS-CLIP [26]
hsa-miR-135a-5p CENPN
HITS-CLIP [26]
hsa-miR-135a-5p LAX1
HITS-CLIP [26]
hsa-miR-135a-5p RAB3GAP2
HITS-CLIP [26]
hsa-miR-135a-5p LRRC15
HITS-CLIP [26]
hsa-miR-135a-5p GPX8
HITS-CLIP [26]
hsa-miR-135a-5p PEX2
HITS-CLIP [26]
hsa-miR-135a-5p SLC19A3
HITS-CLIP [27]
hsa-miR-135a-5p COX6B1
HITS-CLIP [27]
hsa-miR-135a-5p MPL
HITS-CLIP [24]
hsa-miR-135a-5p NSA2
HITS-CLIP [24]
hsa-miR-135a-5p TSC22D2
HITS-CLIP [24]
hsa-miR-135a-5p SKIL
HITS-CLIP [24]
hsa-miR-135a-5p MBNL1
HITS-CLIP [24]
hsa-miR-135a-5p CEP135
HITS-CLIP [24]
hsa-miR-135a-5p WDR82P1
HITS-CLIP [25]
hsa-miR-135a-5p AMOTL2
HITS-CLIP [25]
hsa-miR-135a-5p PCTP
HITS-CLIP [25]
hsa-miR-135a-5p SNED1
HITS-CLIP [25]
hsa-miR-135a-5p TRIM66
HITS-CLIP [25]

References

authors journal year Pubmed link title
1 Wu et al. Cancer Biol. Ther. 2012 22310976 MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation.
2 Navarro et al. Blood 2009 19666866 Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.
3 Sõber et al. Biochem. Biophys. Res. Commun. 2010 19944075 MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression.
4 Nagel et al. Cancer Res. 2008 18632633 Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.
5 Tang et al. Cell. Signal. 2014 24607788 MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
6 Chen et al. BMC Cancer 2012 22439757 miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10.
7 Yamada et al. Cancer Sci. 2013 23176581 Tumor-suppressive microRNA-135a inhibits cancer cell proliferation by targeting the c-MYC oncogene in renal cell carcinoma.
8 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
9 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
10 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
11 Wu et al. Oncogene 2012 22139076 MiR-135a functions as a selective killer of malignant glioma.
12 Zhou et al. Acta Biochim. Biophys. Sin. (Shanghai) 2012 23017832 MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro.
13 Shin et al. PLoS ONE 2014 24465504 MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.
14 Zhou et al. Cancer Sci. 2014 24903309 MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer.
15 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
16 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
17 Agarwal et al. Biochim. Biophys. Acta 2013 23579070 miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.
18 Issler et al. Neuron 2014 24952960 MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity.
19 Leung et al. Carcinogenesis 2014 24503442 miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway.
20 Zhao et al. Biochem. Biophys. Res. Commun. 2014 25230140 miR-135a inhibition protects A549 cells from LPS-induced apoptosis by targeting Bcl-2.
21 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
22 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
23 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
24 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
25 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
26 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
27 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
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