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hsa-miR-133a-3p (MIMAT0000427) (104 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-133a-3p CDC42
qRT-PCR [1]
Western blot [1]
Luciferase reporter assay [1]
hsa-miR-133a-3p HCN4
Luciferase reporter assay [2]
hsa-miR-133a-3p UCP2
Western blot [3]
hsa-miR-133a-3p KRT7
qRT-PCR [4]
Immunoblot [4]
hsa-miR-133a-3p CACNA1C
Western blot [5]
Luciferase reporter assay [5]
hsa-miR-133a-3p HCN2
qRT-PCR [2]
Western blot [5] [2]
Luciferase reporter assay [2] [5]
hsa-miR-133a-3p PKM
Immunohistochemistry [6]
hsa-miR-133a-3p CASP9
Luciferase reporter assay [7]
hsa-miR-133a-3p KCNQ1
qRT-PCR [8]
5' RACE [8]
Western blot [8]
Luciferase reporter assay [8]
hsa-miR-133a-3p FSCN1
qRT-PCR [9] [10] [11]
microarray [11]
Reporter assay [10] [11]
Western blot [9] [10] [11]
Luciferase reporter assay [12] [9] [10] [11]
hsa-miR-133a-3p KCNH2
qRT-PCR [13]
Western blot [13]
Luciferase reporter assay [13]
hsa-miR-133a-3p TAGLN2
qRT-PCR [14] [15] [16]
microarray [17] [16]
Reporter assay [14]
Western blot [14] [15] [16]
Luciferase reporter assay [14] [15]
Immunohistochemistry [15]
hsa-miR-133a-3p LASP1
qRT-PCR [18] [19]
Reporter assay [19]
Western blot [18] [19]
Luciferase reporter assay [19] [18]
hsa-miR-133a-3p PNP
qRT-PCR [16]
microarray [16]
Western blot [16] [20]
Luciferase reporter assay [20]
hsa-miR-133a-3p MSN
qRT-PCR [21]
Western blot [21]
hsa-miR-133a-3p EGFR
qRT-PCR [22] [23]
Western blot [22] [24]
Luciferase reporter assay [25] [22] [23] [24]
Flow cytometry [22]
hsa-miR-133a-3p VKORC1
Luciferase reporter assay [26]
hsa-miR-133a-3p PRDM16
Luciferase reporter assay [27] [28]
hsa-miR-133a-3p TPM1
microarray [17]
hsa-miR-133a-3p FBN1
microarray [17]
hsa-miR-133a-3p FAM120C
microarray [17]
hsa-miR-133a-3p BCAN
microarray [17]
hsa-miR-133a-3p TCTEX1D2
microarray [17]
hsa-miR-133a-3p ARL6IP1
microarray [17]
hsa-miR-133a-3p RFT1
microarray [17]
hsa-miR-133a-3p SENP1
microarray [17]
hsa-miR-133a-3p SMIM14
microarray [17]
hsa-miR-133a-3p PRELID1
microarray [17]
hsa-miR-133a-3p CNN2
microarray [17]
PAR-CLIP [29]
hsa-miR-133a-3p ARPC5
qRT-PCR [30]
microarray [17] [30]
Western blot [30]
Luciferase reporter assay [30]
hsa-miR-133a-3p FTL
microarray [17]
Western blot [31]
Immunocytochemistry [31]
hsa-miR-133a-3p CERS2
microarray [17]
hsa-miR-133a-3p SEC61B
microarray [17]
hsa-miR-133a-3p PLEKHA3
microarray [17]
hsa-miR-133a-3p COL1A1
Reporter assay [32]
hsa-miR-133a-3p GSTP1
microarray [17]
Reporter assay [17]
hsa-miR-133a-3p SP1
Immunofluorescence [33]
Western blot [33]
Luciferase reporter assay [34] [33]
hsa-miR-133a-3p NR4A2
CLASH [35]
hsa-miR-133a-3p BCL2L1
Western blot [36]
Luciferase reporter assay [36]
hsa-miR-133a-3p MCL1
Western blot [36]
Luciferase reporter assay [36]
hsa-miR-133a-3p RFFL
qRT-PCR [37]
microarray [37]
Western blot [37]
Luciferase reporter assay [37]
hsa-miR-133a-3p IGF1R
qRT-PCR [38] [39]
Western blot [38] [39]
Luciferase reporter assay [39] [38]
hsa-miR-133a-3p FAM160B1
HITS-CLIP [40]
hsa-miR-133a-3p UBA2
qRT-PCR [41]
microarray [41]
In situ hybridization [41]
Western blot [41]
Luciferase reporter assay [41]
hsa-miR-133a-3p MMP14
qRT-PCR [42]
Western blot [42]
Luciferase reporter assay [42]
hsa-miR-133a-3p ANXA2
qRT-PCR [41]
microarray [41]
In situ hybridization [41]
Western blot [41]
Luciferase reporter assay [41]
hsa-miR-133a-3p SNX30
qRT-PCR [41]
microarray [41]
In situ hybridization [41]
Western blot [41]
Luciferase reporter assay [41]
hsa-miR-133a-3p SGMS2
qRT-PCR [41]
microarray [41]
In situ hybridization [41]
Western blot [41]
Luciferase reporter assay [41]
hsa-miR-133a-3p PDLIM5
qRT-PCR [18]
Western blot [18]
Luciferase reporter assay [18]
hsa-miR-133a-3p PACS2
PAR-CLIP [29]
hsa-miR-133a-3p BCL3
PAR-CLIP [29]
hsa-miR-133a-3p SESN2
PAR-CLIP [29]
hsa-miR-133a-3p EFHD2
PAR-CLIP [29]
hsa-miR-133a-3p EMID1
PAR-CLIP [29]
hsa-miR-133a-3p PRRT2
PAR-CLIP [29]
hsa-miR-133a-3p CDKN1A
PAR-CLIP [43] [29]
hsa-miR-133a-3p MC2R
PAR-CLIP [44]
hsa-miR-133a-3p SESN3
PAR-CLIP [44]
hsa-miR-133a-3p RHOQ
PAR-CLIP [44] [43]
hsa-miR-133a-3p HIST2H2AC
PAR-CLIP [44]
hsa-miR-133a-3p DCAKD
PAR-CLIP [43]
hsa-miR-133a-3p THBS2
PAR-CLIP [43]
hsa-miR-133a-3p ZBTB37
PAR-CLIP [43]
hsa-miR-133a-3p SNX33
PAR-CLIP [43]
hsa-miR-133a-3p RNF103-CHMP3
PAR-CLIP [40] [43]
hsa-miR-133a-3p MYPN
PAR-CLIP [43]
hsa-miR-133a-3p CHMP3
PAR-CLIP [40] [43]
hsa-miR-133a-3p IBA57
PAR-CLIP [40]
hsa-miR-133a-3p PSMG1
PAR-CLIP [40]
hsa-miR-133a-3p UGT2B10
PAR-CLIP [40]
hsa-miR-133a-3p SYAP1
PAR-CLIP [40]
hsa-miR-133a-3p CDK5R1
PAR-CLIP [40]
hsa-miR-133a-3p ATP13A3
PAR-CLIP [40]
hsa-miR-133a-3p ZFP28
PAR-CLIP [45]
hsa-miR-133a-3p SUPT16H
PAR-CLIP [45]
hsa-miR-133a-3p PTMA
PAR-CLIP [45]
hsa-miR-133a-3p C11orf24
PAR-CLIP [45]
hsa-miR-133a-3p NCDN
HITS-CLIP [46] [47] [48]
hsa-miR-133a-3p CCDC39
HITS-CLIP [47]
hsa-miR-133a-3p ITPKB
HITS-CLIP [47]
hsa-miR-133a-3p TMEM59
HITS-CLIP [47]
hsa-miR-133a-3p CCNI
HITS-CLIP [47]
hsa-miR-133a-3p ALDOC
HITS-CLIP [47]
hsa-miR-133a-3p TXNRD3NB
HITS-CLIP [47]
hsa-miR-133a-3p PDE1A
HITS-CLIP [47]
hsa-miR-133a-3p RBMXL1
HITS-CLIP [47]
hsa-miR-133a-3p RNF168
HITS-CLIP [47]
hsa-miR-133a-3p C17orf64
HITS-CLIP [47]
hsa-miR-133a-3p ZMAT4
HITS-CLIP [47]
hsa-miR-133a-3p TRIM71
HITS-CLIP [47]
hsa-miR-133a-3p IP6K1
HITS-CLIP [47]
hsa-miR-133a-3p FOSL2
HITS-CLIP [47]
hsa-miR-133a-3p MLEC
HITS-CLIP [46]
hsa-miR-133a-3p PLEKHG2
HITS-CLIP [46]
hsa-miR-133a-3p PSMC4
HITS-CLIP [46]
hsa-miR-133a-3p SERPINH1
HITS-CLIP [46]
hsa-miR-133a-3p PER2
HITS-CLIP [46]
hsa-miR-133a-3p ABHD18
HITS-CLIP [46]
hsa-miR-133a-3p ANGPT4
HITS-CLIP [49]
hsa-miR-133a-3p PIGR
HITS-CLIP [49]
hsa-miR-133a-3p SFTPB
HITS-CLIP [49]
hsa-miR-133a-3p APOL6
HITS-CLIP [49]
hsa-miR-133a-3p CMTM4
HITS-CLIP [49]
hsa-miR-133a-3p NFAM1
HITS-CLIP [49]

References

authors journal year Pubmed link title
1 Cheng et al. Cell. Signal. 2014 25152372 miR-133 is a key negative regulator of CDC42-PAK pathway in gastric cancer.
2 Luo et al. J. Biol. Chem. 2008 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart.
3 Bandyopadhyay et al. Biochem. Biophys. Res. Commun. 2013 23988448 MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2.
4 Ichimi et al. Int. J. Cancer 2009 19378336 Identification of novel microRNA targets based on microRNA signatures in bladder cancer.
5 Lu et al. Nucleic Acids Res. 2009 19136465 A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference.
6 Wong et al. Int. J. Cancer 2008 18464261 Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
7 Xu et al. J. Cell. Sci. 2007 17715156 The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes.
8 Luo et al. J. Cell. Physiol. 2007 17443681 Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and potential implications in regional heterogeneity of their expressions.
9 Chiyomaru et al. Br. J. Cancer 2010 20160723 miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer.
10 et al. None 20198616
11 Kano et al. Int. J. Cancer 2010 21351259 miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma.
12 Wu et al. BMC Cancer 2012 22292984 Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion.
13 Xiao et al. J. Biol. Chem. 2007 17344217 MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.
14 Kawakami et al. Eur. J. Cancer 2012 21745735 The functional significance of miR-1 and miR-133a in renal cell carcinoma.
15 Sakumoto et al. Rev Paul Med 1990 2130430 [Metoclopramide action on the mammary glands of albino rats in lactation or in early weaning: morphological study].
16 Nohata et al. Int. J. Oncol. 2011 21701775 Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma.
17 Uchida et al. Urol. Oncol. 2013 21396852 MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines.
18 Wang et al. Eur. J. Cancer 2013 23968734 miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.
19 Chiyomaru et al. Urol. Oncol. 2012 20843712 Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.
20 Kojima et al. Br. J. Cancer 2012 22068816 Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer.
21 Kinoshita et al. Biochem. Biophys. Res. Commun. 2012 22266319 Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.
22 Cui et al. FEBS J. 2013 23786162 microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway.
23 Wang et al. PLoS ONE 2014 24816813 MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
24 Tao et al. Oncol. Rep. 2012 22407299 microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor.
25 Lee et al. Biomaterials 2013 23069713 The promotion of cardiogenic differentiation of hMSCs by targeting epidermal growth factor receptor using microRNA-133a.
26 Pérez-Andreu et al. Mol. Med. 2013 23154637 miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
27 Yin et al. Cell Metab. 2013 23395168 MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.
28 Liu et al. PLoS Genet. 2013 23874225 miR-133a regulates adipocyte browning in vivo.
29 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
30 Kinoshita et al. Int. J. Oncol. 2012 22378351 Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.
31 Chekhun et al. Int. J. Oncol. 2013 23969999 Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.
32 Castoldi et al. J. Cell. Physiol. 2012 21769867 MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension.
33 Qiu et al. FEBS Lett. 2014 24613927 MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer.
34 Zhang et al. PLoS ONE 2012 22911796 Attenuation of p38-mediated miR-1/133 expression facilitates myoblast proliferation during the early stage of muscle regeneration.
35 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
36 Ji et al. Bone 2013 23756231 MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1.
37 Dong et al. Mol. Cancer Res. 2013 23723074 Tumor suppressor functions of miR-133a in colorectal cancer.
38 Gong et al. World J. Gastroenterol. 2015 25780292 Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R.
39 Guo et al. Tumour Biol. 2014 24127040 miR-133a suppresses ovarian cancer cell proliferation by directly targeting insulin-like growth factor 1 receptor.
40 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
41 Fujiwara et al. Stem Cells 2014 24715690 Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.
42 Xu et al. Oncol. Rep. 2013 23783274 miR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14.
43 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
44 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
45 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
46 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
47 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
48 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
49 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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