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hsa-miR-421 (MIMAT0003339) (222 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-421 RBMXL1
qRT-PCR [1]
Western blot [1]
hsa-miR-421 CBX7
qRT-PCR [1]
Western blot [1]
hsa-miR-421 ATM
qRT-PCR [2] [3]
Western blot [2] [3]
Luciferase reporter assay [2] [4] [3]
hsa-miR-421 SMAD4
qRT-PCR [5]
Western blot [5]
Luciferase reporter assay [5]
hsa-miR-421 NSL1
Sequencing [6]
hsa-miR-421 SRSF7
Sequencing [6]
hsa-miR-421 GID8
Sequencing [6]
hsa-miR-421 EIF3K
Sequencing [6]
hsa-miR-421 MAPK8
Sequencing [6]
CLASH [7]
hsa-miR-421 LIMS1
Sequencing [6]
hsa-miR-421 ZNF30
Sequencing [6]
hsa-miR-421 GID4
Sequencing [6]
hsa-miR-421 DDX39A
Sequencing [6]
CLASH [7]
hsa-miR-421 ZNF678
Sequencing [6]
PAR-CLIP [6]
hsa-miR-421 MIS18BP1
Sequencing [6]
hsa-miR-421 NXPE3
Sequencing [6]
hsa-miR-421 RNF138
Sequencing [6]
hsa-miR-421 LIN7C
Sequencing [6]
hsa-miR-421 RGMB
Sequencing [6]
hsa-miR-421 SREK1IP1
Sequencing [6]
hsa-miR-421 TAF9
Sequencing [6]
hsa-miR-421 NR6A1
Sequencing [6]
hsa-miR-421 CD46
Sequencing [6]
PAR-CLIP [8]
hsa-miR-421 NDC1
Sequencing [6]
hsa-miR-421 CREBZF
Sequencing [6]
hsa-miR-421 POLR2D
Sequencing [6]
PAR-CLIP [8] [9]
hsa-miR-421 CEBPB
Sequencing [6]
hsa-miR-421 FAM160B1
Sequencing [6]
PAR-CLIP [8]
hsa-miR-421 VAPA
Sequencing [6]
hsa-miR-421 DDX3X
Sequencing [6]
PAR-CLIP [8]
hsa-miR-421 CREBRF
Sequencing [6]
hsa-miR-421 FAM122A
Sequencing [6]
hsa-miR-421 DNAJC27
Sequencing [6]
hsa-miR-421 ZFP36L2
Sequencing [6]
hsa-miR-421 RND3
Sequencing [6]
hsa-miR-421 ATG2B
Sequencing [6]
PAR-CLIP [8]
hsa-miR-421 TTC37
Sequencing [6]
hsa-miR-421 RBBP7
Sequencing [6]
hsa-miR-421 AFF4
Sequencing [6]
hsa-miR-421 NIPBL
Sequencing [6]
hsa-miR-421 LMCD1
CLASH [7]
hsa-miR-421 RANBP2
CLASH [7]
hsa-miR-421 USO1
CLASH [7]
hsa-miR-421 AP3B1
CLASH [7]
hsa-miR-421 PAXBP1
CLASH [7]
hsa-miR-421 PPARGC1A
CLASH [7]
hsa-miR-421 FAT2
CLASH [7]
hsa-miR-421 MTHFD2
CLASH [7]
hsa-miR-421 GCSH
CLASH [7]
hsa-miR-421 LARS2
CLASH [7]
hsa-miR-421 RPL18A
CLASH [7]
hsa-miR-421 EIF4A1
CLASH [7]
hsa-miR-421 DUSP3
CLASH [7]
hsa-miR-421 PHKA1
CLASH [7]
hsa-miR-421 HIST2H4B
CLASH [7]
hsa-miR-421 DDX20
CLASH [7]
hsa-miR-421 CAP1
CLASH [7]
hsa-miR-421 ACOT9
CLASH [7]
hsa-miR-421 EIF4G2
CLASH [7]
hsa-miR-421 MSL3
CLASH [7]
hsa-miR-421 CEP57
CLASH [7]
hsa-miR-421 RPL26L1
CLASH [7]
hsa-miR-421 PCNX4
CLASH [7]
hsa-miR-421 SENP7
CLASH [7]
hsa-miR-421 DOK4
CLASH [7]
hsa-miR-421 OTUD1
CLASH [7]
hsa-miR-421 CDC42SE2
CLASH [7]
hsa-miR-421 MRPL38
CLASH [7]
hsa-miR-421 ATXN2L
CLASH [7]
hsa-miR-421 TSR1
CLASH [7]
hsa-miR-421 GFOD2
CLASH [7]
hsa-miR-421 RAB2B
CLASH [7]
hsa-miR-421 PPP1R13B
CLASH [7]
hsa-miR-421 NPM1
CLASH [7]
hsa-miR-421 PARP10
CLASH [7]
hsa-miR-421 PQLC2
CLASH [7]
hsa-miR-421 SLC25A6
CLASH [7]
hsa-miR-421 PRR7
CLASH [7]
hsa-miR-421 AGO1
CLASH [7]
hsa-miR-421 FBXO11
CLASH [7]
hsa-miR-421 AHNAK
CLASH [7]
hsa-miR-421 GRK6
CLASH [7]
hsa-miR-421 SLIT1
CLASH [7]
hsa-miR-421 SLC9A6
CLASH [7]
hsa-miR-421 FAM172A
CLASH [7]
hsa-miR-421 SPECC1L
CLASH [7]
hsa-miR-421 SEPT2
CLASH [7]
hsa-miR-421 CTC1
CLASH [7]
hsa-miR-421 CDC37
CLASH [7]
hsa-miR-421 ZNF280C
CLASH [7]
hsa-miR-421 ISY1
CLASH [7]
hsa-miR-421 ZMYND8
CLASH [7]
hsa-miR-421 SRP9
CLASH [7]
hsa-miR-421 GAREM2
CLASH [7]
hsa-miR-421 INPP4A
CLASH [7]
hsa-miR-421 MLXIP
CLASH [7]
hsa-miR-421 DUS3L
CLASH [7]
hsa-miR-421 FKBP8
CLASH [7]
hsa-miR-421 DNAJC16
CLASH [7]
hsa-miR-421 COPRS
CLASH [7]
hsa-miR-421 TUBA1B
CLASH [7]
hsa-miR-421 CASP2
CLASH [7]
hsa-miR-421 RPS18
CLASH [7]
hsa-miR-421 HSP90AA1
CLASH [7]
hsa-miR-421 COPA
CLASH [7]
hsa-miR-421 RAB11FIP1
CLASH [7]
hsa-miR-421 RHOB
CLASH [7]
hsa-miR-421 PSME1
CLASH [7]
hsa-miR-421 MCFD2
HITS-CLIP [10]
CLASH [7]
hsa-miR-421 CNOT1
CLASH [7]
hsa-miR-421 ZC3H7B
CLASH [7]
hsa-miR-421 AMZ2
CLASH [7]
hsa-miR-421 HTT
CLASH [7]
hsa-miR-421 LBR
CLASH [7]
hsa-miR-421 NCDN
CLASH [7]
hsa-miR-421 RASL10B
CLASH [7]
hsa-miR-421 RIF1
CLASH [7]
hsa-miR-421 EEF1A1
CLASH [7]
hsa-miR-421 ITPK1
CLASH [7]
hsa-miR-421 RPS10
CLASH [7]
hsa-miR-421 SRPRA
CLASH [7]
hsa-miR-421 FAM168B
CLASH [7]
hsa-miR-421 CMAS
CLASH [7]
hsa-miR-421 TRIM27
CLASH [7]
hsa-miR-421 NR3C1
CLASH [7]
hsa-miR-421 ATP6V0C
CLASH [7]
hsa-miR-421 ZXDA
CLASH [7]
hsa-miR-421 SFXN1
CLASH [7]
hsa-miR-421 DFFB
CLASH [7]
hsa-miR-421 RASAL1
CLASH [7]
hsa-miR-421 KIAA0100
CLASH [7]
hsa-miR-421 CD276
CLASH [7]
hsa-miR-421 RHOBTB2
CLASH [7]
hsa-miR-421 SMCHD1
CLASH [7]
hsa-miR-421 FAM32A
CLASH [7]
hsa-miR-421 RAB26
CLASH [7]
hsa-miR-421 TMEM109
CLASH [7]
hsa-miR-421 NCAPG
CLASH [7]
hsa-miR-421 PRCC
CLASH [7]
hsa-miR-421 PPP2CB
CLASH [7]
hsa-miR-421 PHLPP2
CLASH [7]
hsa-miR-421 RALGAPB
CLASH [7]
hsa-miR-421 HADHA
CLASH [7]
hsa-miR-421 P3H4
CLASH [7]
hsa-miR-421 CASP3
qRT-PCR [11]
Western blot [11]
hsa-miR-421 PNPO
PAR-CLIP [8]
hsa-miR-421 XIAP
PAR-CLIP [6] [8] [12]
hsa-miR-421 ZNF652
HITS-CLIP [13]
hsa-miR-421 ID4
PAR-CLIP [6]
hsa-miR-421 FOXO4
Western blot [14]
Luciferase reporter assay [14]
hsa-miR-421 NBPF8
PAR-CLIP [15] [16]
hsa-miR-421 CASTOR2
PAR-CLIP [15]
hsa-miR-421 CEBPD
PAR-CLIP [9]
hsa-miR-421 MTAP
PAR-CLIP [9]
hsa-miR-421 TMEM37
PAR-CLIP [9]
hsa-miR-421 VPS37C
PAR-CLIP [9]
hsa-miR-421 TM9SF1
PAR-CLIP [9]
hsa-miR-421 VMP1
HITS-CLIP [17] [18] [10] [8] [13] [19] [20]
PAR-CLIP [16] [6] [8] [9]
hsa-miR-421 ARHGAP22
PAR-CLIP [6] [12] [9]
hsa-miR-421 FAM155B
PAR-CLIP [21]
hsa-miR-421 CBWD1
PAR-CLIP [16] [8] [22]
hsa-miR-421 CBWD5
PAR-CLIP [16] [8] [22]
hsa-miR-421 PPTC7
PAR-CLIP [16] [6] [22]
hsa-miR-421 PDPK1
PAR-CLIP [16]
hsa-miR-421 TSC22D3
PAR-CLIP [16] [8]
hsa-miR-421 GALK2
PAR-CLIP [16] [6]
hsa-miR-421 UBE2D3
PAR-CLIP [8] [16] [6]
hsa-miR-421 GJB7
PAR-CLIP [12]
hsa-miR-421 SLC6A13
PAR-CLIP [12]
hsa-miR-421 PARP11
PAR-CLIP [12]
hsa-miR-421 HOXA9
PAR-CLIP [6] [8] [12]
hsa-miR-421 BTRC
PAR-CLIP [12]
hsa-miR-421 TRIM4
PAR-CLIP [8] [12]
hsa-miR-421 SLC28A1
PAR-CLIP [12]
hsa-miR-421 SYT4
PAR-CLIP [12]
hsa-miR-421 JARID2
PAR-CLIP [12]
hsa-miR-421 IGF1
PAR-CLIP [12]
hsa-miR-421 RGR
HITS-CLIP [19]
PAR-CLIP [8]
hsa-miR-421 TPRG1L
PAR-CLIP [8]
hsa-miR-421 RSRC1
PAR-CLIP [8]
hsa-miR-421 ASB16
PAR-CLIP [8]
hsa-miR-421 PRICKLE2
PAR-CLIP [8]
hsa-miR-421 GOSR1
PAR-CLIP [8]
hsa-miR-421 GJD3
PAR-CLIP [8]
hsa-miR-421 GAS1
PAR-CLIP [6] [8]
hsa-miR-421 CSNK1A1
PAR-CLIP [8]
hsa-miR-421 TUBB2A
PAR-CLIP [6]
hsa-miR-421 REST
PAR-CLIP [6]
hsa-miR-421 YTHDF1
PAR-CLIP [6]
hsa-miR-421 UQCRFS1
PAR-CLIP [6]
hsa-miR-421 TXNRD1
PAR-CLIP [6]
hsa-miR-421 RACGAP1
PAR-CLIP [6]
hsa-miR-421 QSER1
PAR-CLIP [6]
hsa-miR-421 MYBPC1
HITS-CLIP [13]
hsa-miR-421 VSIG10
HITS-CLIP [13]
hsa-miR-421 TNRC6C
HITS-CLIP [18] [13]
hsa-miR-421 RREB1
HITS-CLIP [18] [13]
hsa-miR-421 FAM89A
HITS-CLIP [13]
hsa-miR-421 TCF7L2
HITS-CLIP [13]
hsa-miR-421 INTU
HITS-CLIP [13]
hsa-miR-421 FBXL16
HITS-CLIP [13]
hsa-miR-421 CSE1L
HITS-CLIP [13]
hsa-miR-421 GRK3
HITS-CLIP [13] [20]
hsa-miR-421 CD226
HITS-CLIP [13]
hsa-miR-421 TET1
HITS-CLIP [13]
hsa-miR-421 ZNF208
HITS-CLIP [13]
hsa-miR-421 POLG
HITS-CLIP [13]
hsa-miR-421 TREM1
HITS-CLIP [13]
hsa-miR-421 NPTX1
HITS-CLIP [13]
hsa-miR-421 NFE2L1
HITS-CLIP [13]
hsa-miR-421 KCNN3
HITS-CLIP [13]
hsa-miR-421 KCNMB4
HITS-CLIP [13]
hsa-miR-421 SOD2
HITS-CLIP [10]
hsa-miR-421 ZFP64
HITS-CLIP [10]
hsa-miR-421 NEGR1
HITS-CLIP [10]
hsa-miR-421 COL4A1
HITS-CLIP [10]
hsa-miR-421 BAHD1
HITS-CLIP [10]
hsa-miR-421 CCDC39
HITS-CLIP [18]
hsa-miR-421 BACE1
HITS-CLIP [18]
hsa-miR-421 MAZ
HITS-CLIP [18]
hsa-miR-421 TLK1
HITS-CLIP [18]
hsa-miR-421 RHOH
HITS-CLIP [18]

References

authors journal year Pubmed link title
1 Jiang et al. J. Gastroenterol. 2010 19802518 Increased expression of miR-421 in human gastric carcinoma and its clinical association.
2 Hu et al. Proc. Natl. Acad. Sci. U.S.A. 2010 20080624 ATM is down-regulated by N-Myc-regulated microRNA-421.
3 Shen et al. Proc. Natl. Acad. Sci. U.S.A. 2013 23818585 The mTOR pathway negatively controls ATM by up-regulating miRNAs.
4 Mansour et al. Radiother Oncol 2013 23199656 Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.
5 Hao et al. Biochem. Biophys. Res. Commun. 2011 21352803 MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer.
6 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
7 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
8 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
9 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
10 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
11 Wu et al. Asian Pac. J. Cancer Prev. 2014 25041019 MiR-421 regulates apoptosis of BGC-823 gastric cancer cells by targeting caspase-3.
12 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
13 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
14 Chen et al. Biochem. Biophys. Res. Commun. 2013 23707940 miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4.
15 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
16 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
17 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
18 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
19 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
20 Haecker et al. PLoS Pathog. 2012 22927820 Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
21 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
22 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
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