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hsa-miR-224-5p (MIMAT0000281) (112 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-224-5p KLK10
qRT-PCR [1]
Luciferase reporter assay [1]
hsa-miR-224-5p CXCR4
qRT-PCR [2]
Western blot [2]
Luciferase reporter assay [2]
hsa-miR-224-5p CDC42
qRT-PCR [2] [3] [4]
microarray [3]
Western blot [2] [3]
Luciferase reporter assay [2]
hsa-miR-224-5p RAB9B
Northern blot [5]
microarray [5]
hsa-miR-224-5p PDGFRB
Northern blot [5]
microarray [5]
hsa-miR-224-5p AP2M1
Luciferase reporter assay [6]
hsa-miR-224-5p CD40
qRT-PCR [7]
microarray [7]
hsa-miR-224-5p API5
qRT-PCR [8]
Western blot [8]
Luciferase reporter assay [8]
hsa-miR-224-5p EYA4
Northern blot [9]
qRT-PCR [9]
In situ hybridization [9]
Immunofluorescence [9]
Western blot [9]
Luciferase reporter assay [9]
hsa-miR-224-5p EDNRA
Northern blot [9]
qRT-PCR [9]
In situ hybridization [9]
Immunofluorescence [9]
Western blot [9]
Luciferase reporter assay [9]
hsa-miR-224-5p DIO1
qRT-PCR [10]
Western blot [10]
Luciferase reporter assay [10]
hsa-miR-224-5p SMAD4
qRT-PCR [11]
Western blot [12] [11]
Luciferase reporter assay [12]
hsa-miR-224-5p PEBP1
qRT-PCR [13]
Western blot [13]
Luciferase reporter assay [14] [13]
Flow cytometry [13]
hsa-miR-224-5p ARSB
CLASH [15]
hsa-miR-224-5p ADNP2
CLASH [15]
hsa-miR-224-5p TCEAL1
qRT-PCR [16]
microarray [16]
Western blot [16]
Luciferase reporter assay [16]
Flow cytometry [16]
hsa-miR-224-5p PHLPP1
Western blot [17]
Luciferase reporter assay [17]
Immunoprecipitaion [17]
hsa-miR-224-5p DPYSL2
qRT-PCR [18]
Western blot [18]
hsa-miR-224-5p KRAS
qRT-PCR [18]
Western blot [18]
hsa-miR-224-5p HOXD10
qRT-PCR [19]
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-224-5p PTX3
qRT-PCR [20]
Western blot [20]
Luciferase reporter assay [20]
hsa-miR-224-5p TXNIP
PAR-CLIP [21]
hsa-miR-224-5p TMTC3
PAR-CLIP [22]
hsa-miR-224-5p TNRC6A
PAR-CLIP [23]
hsa-miR-224-5p COX6B1
PAR-CLIP [24] [25]
hsa-miR-224-5p QKI
PAR-CLIP [21] [25]
hsa-miR-224-5p NPTN
PAR-CLIP [25]
hsa-miR-224-5p NUFIP2
PAR-CLIP [22]
hsa-miR-224-5p AKIRIN1
PAR-CLIP [26] [22] [23] [24] [25]
hsa-miR-224-5p SERPINE1
PAR-CLIP [26]
hsa-miR-224-5p CLDN12
PAR-CLIP [21] [24] [23]
hsa-miR-224-5p ZNF207
PAR-CLIP [25]
hsa-miR-224-5p MYLIP
PAR-CLIP [24]
hsa-miR-224-5p CSTF2
PAR-CLIP [24]
hsa-miR-224-5p EFNA3
PAR-CLIP [24]
hsa-miR-224-5p PRRG4
PAR-CLIP [24]
hsa-miR-224-5p MBD2
qRT-PCR [27]
microarray [27]
In situ hybridization [27]
ChIP [27]
Western blot [27]
Luciferase reporter assay [27]
hsa-miR-224-5p TPD52
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-224-5p SERPINF2
qRT-PCR [29]
Western blot [29]
hsa-miR-224-5p TRIB1
qRT-PCR [30]
microarray [30]
In situ hybridization [30]
Western blot [30]
Luciferase reporter assay [30]
hsa-miR-224-5p BCL2
qRT-PCR [3]
microarray [3]
Western blot [3]
hsa-miR-224-5p PAK2
qRT-PCR [3]
microarray [3]
Western blot [3]
hsa-miR-224-5p CDH1
qRT-PCR [3]
hsa-miR-224-5p GALNT1
PAR-CLIP [31]
hsa-miR-224-5p ZNF573
PAR-CLIP [22]
hsa-miR-224-5p MPDU1
PAR-CLIP [22]
hsa-miR-224-5p ZKSCAN8
PAR-CLIP [22]
hsa-miR-224-5p WRN
PAR-CLIP [22]
hsa-miR-224-5p USP6NL
PAR-CLIP [22]
hsa-miR-224-5p TADA2B
PAR-CLIP [22]
hsa-miR-224-5p GIGYF1
PAR-CLIP [22]
hsa-miR-224-5p F3
PAR-CLIP [21] [24] [25] [22]
hsa-miR-224-5p ZWINT
PAR-CLIP [22]
hsa-miR-224-5p PSMD3
PAR-CLIP [22]
hsa-miR-224-5p RAB15
PAR-CLIP [26] [22]
hsa-miR-224-5p TOM1L2
PAR-CLIP [32]
hsa-miR-224-5p KCTD2
PAR-CLIP [25] [23]
hsa-miR-224-5p SLC46A3
PAR-CLIP [23]
hsa-miR-224-5p SLC12A5
PAR-CLIP [23]
hsa-miR-224-5p NCOA3
PAR-CLIP [23]
hsa-miR-224-5p HNRNPC
PAR-CLIP [23]
hsa-miR-224-5p KBTBD8
PAR-CLIP [21] [25]
hsa-miR-224-5p HOXB3
PAR-CLIP [21] [25]
hsa-miR-224-5p CACNG7
PAR-CLIP [26] [21] [24]
hsa-miR-224-5p HSP90AA1
PAR-CLIP [21] [24]
hsa-miR-224-5p ADAP1
PAR-CLIP [21] [24] [26]
hsa-miR-224-5p SLC7A14
PAR-CLIP [21]
hsa-miR-224-5p F8A2
PAR-CLIP [21]
hsa-miR-224-5p F8A3
PAR-CLIP [21]
hsa-miR-224-5p ZNF135
PAR-CLIP [26]
hsa-miR-224-5p ITGB3BP
PAR-CLIP [26]
hsa-miR-224-5p TOMM20
PAR-CLIP [24] [25] [26]
hsa-miR-224-5p C17orf82
PAR-CLIP [26]
hsa-miR-224-5p STARD5
PAR-CLIP [26]
hsa-miR-224-5p YES1
PAR-CLIP [26]
hsa-miR-224-5p TPR
PAR-CLIP [26]
hsa-miR-224-5p FAM84B
PAR-CLIP [26]
hsa-miR-224-5p ZNF585B
PAR-CLIP [25]
hsa-miR-224-5p XPO1
PAR-CLIP [24] [25]
hsa-miR-224-5p MED13
PAR-CLIP [25]
hsa-miR-224-5p CHAC1
PAR-CLIP [24] [25]
hsa-miR-224-5p FEM1B
PAR-CLIP [24] [25]
hsa-miR-224-5p ENC1
PAR-CLIP [25]
hsa-miR-224-5p RPL15
PAR-CLIP [24]
hsa-miR-224-5p HNRNPF
PAR-CLIP [24]
hsa-miR-224-5p C12orf49
PAR-CLIP [24]
hsa-miR-224-5p SEC14L5
PAR-CLIP [24]
hsa-miR-224-5p COASY
PAR-CLIP [24]
hsa-miR-224-5p IGF1R
PAR-CLIP [24]
hsa-miR-224-5p GRPEL2
PAR-CLIP [24]
hsa-miR-224-5p LONRF2
HITS-CLIP [33]
hsa-miR-224-5p COQ7
HITS-CLIP [33]
hsa-miR-224-5p GABARAPL3
HITS-CLIP [33]
hsa-miR-224-5p TIAL1
HITS-CLIP [33]
hsa-miR-224-5p RBM3
HITS-CLIP [34] [33]
hsa-miR-224-5p MAP2K2
HITS-CLIP [33]
hsa-miR-224-5p C8orf46
HITS-CLIP [33]
hsa-miR-224-5p KRT74
HITS-CLIP [33]
hsa-miR-224-5p GORAB
HITS-CLIP [33]
hsa-miR-224-5p GNB4
HITS-CLIP [33]
hsa-miR-224-5p SLC41A1
HITS-CLIP [33]
hsa-miR-224-5p PELI1
HITS-CLIP [33]
hsa-miR-224-5p LHFPL2
HITS-CLIP [33]
hsa-miR-224-5p PIGO
HITS-CLIP [35]
hsa-miR-224-5p MITF
HITS-CLIP [35]
hsa-miR-224-5p KDELR1
HITS-CLIP [35]
hsa-miR-224-5p ABCC1
HITS-CLIP [35]
hsa-miR-224-5p MOCS2
HITS-CLIP [34]
hsa-miR-224-5p ASCC1
HITS-CLIP [34]
hsa-miR-224-5p IL20RB
HITS-CLIP [34]
hsa-miR-224-5p ARL4D
HITS-CLIP [34]
hsa-miR-224-5p HIPK3
HITS-CLIP [34]

References

authors journal year Pubmed link title
1 White et al. Br. J. Cancer 2010 20354523 Three dysregulated miRNAs control kallikrein 10 expression and cell proliferation in ovarian cancer.
2 Zhu et al. Oncogene 2010 20023705 Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
3 Zhang et al. J. Gastroenterol. Hepatol. 2013 22989374 Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma.
4 Ke et al. Dis. Markers 2014 24817781 MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.
5 Murakami et al. Oncogene 2006 16331254 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.
6 Mouillet et al. FASEB J. 2010 20065103 MiR-205 silences MED1 in hypoxic primary human trophoblasts.
7 Mees et al. Ann. Surg. Oncol. 2009 19475450 Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas.
8 Wang et al. J. Biol. Chem. 2008 18319255 Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.
9 Hildebrand et al. J. Invest. Dermatol. 2011 20827281 A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo.
10 Boguslawska et al. PLoS ONE 2011 21912701 MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.
11 Wang et al. PLoS ONE 2013 23922662 MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival.
12 Yao et al. Mol. Endocrinol. 2010 20118412 MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.
13 Liu et al. Tumour Biol. 2014 25017365 RKIP suppresses gastric cancer cell proliferation and invasion and enhances apoptosis regulated by microRNA-224.
14 Huang et al. Biochem. Biophys. Res. Commun. 2012 22809510 MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.
15 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
16 Olaru et al. Inflamm. Bowel Dis. 2013 23399735 MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease.
17 Liao et al. Clin. Cancer Res. 2013 23846336 microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2.
18 Hashimoto et al. PLoS ONE 2013 23667495 Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer.
19 Li et al. J. Gastroenterol. Hepatol. 2014 24219032 miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma.
20 Rudnicki et al. Hum. Mol. Genet. 2014 24470395 microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation.
21 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
22 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
23 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
24 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
25 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
26 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
27 Yuan et al. Gastroenterology 2013 23770133 Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice.
28 Goto et al. FEBS Lett. 2014 24768995 Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.
29 Upraity et al. Biochem. Biophys. Res. Commun. 2014 24785373 MiR-224 expression increases radiation sensitivity of glioblastoma cells.
30 Lin et al. Int. J. Cancer 2014 24382668 MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1.
31 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
32 Majoros et al. Nat. Methods 2013 23708386 MicroRNA target site identification by integrating sequence and binding information.
33 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
34 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
35 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
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