miRCarta - targets

hsa-miR-223-3p (MIMAT0000280) (83 targets) in miRTarBase

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miRNA

gene name

experiments

hsa-miR-223-3p

Hnf1a


qRT-PCR	[1]
Immunocytochemistry	[1]

hsa-miR-223-3p

STMN1


qRT-PCR	[2] [3] [4]
Western blot	[2] [3] [4]
Luciferase reporter assay	[3] [4] [2]
Flow cytometry	[4]
Immunohistochemistry	[4]

hsa-miR-223-3p

LMO2


qRT-PCR	[5]
Reporter assay	[6]
Western blot	[5]
Luciferase reporter assay	[5]

hsa-miR-223-3p

E2F1


Western blot	[7]
Luciferase reporter assay	[7]

hsa-miR-223-3p

NFIX


Luciferase reporter assay	[8]

hsa-miR-223-3p

NFIA


qRT-PCR	[9] [10]
microarray	[9]
Reporter assay	[10]
Western blot	[10]
Luciferase reporter assay	[10] [11]

hsa-miR-223-3p

CHUK


qRT-PCR	[12]
Western blot	[12]
Luciferase reporter assay	[12]

hsa-miR-223-3p

FBXW7


qRT-PCR	[13] [14] [15]
microarray	[13]
Western blot	[15] [13] [14]
Luciferase reporter assay	[16] [13] [14] [15]
Flow cytometry	[13] [14]

hsa-miR-223-3p

IGF1R


qRT-PCR	[17] [18]
microarray	[18]
Western blot	[19] [17] [18]
Luciferase reporter assay	[16] [19]

hsa-miR-223-3p

LIF


Western blot	[20]
Luciferase reporter assay	[20]

Show entries

References

	authors	journal	year	Pubmed link	title
1	Li et al.	Arthritis Rheum.	2012	22674011	Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223.
2	Masciarelli et al.	Oncogene	2014	23584479	Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells.
3	Wong et al.	Gastroenterology	2008	18555017	MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.
4	Kang et al.	PLoS ONE	2012	22470493	Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer.
5	Felli et al.	Haematologica	2009	19278969	MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis.
6	Yuan et al.	J. Cell. Mol. Med.	2009	19017354	MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells.
7	Pulikkan et al.	Blood	2010	20029046	Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.
8	Sun et al.	Nucleic Acids Res.	2010	19850724	Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR.
9	Garzon et al.	Oncogene	2007	17260024	MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.
10	Fazi et al.	Cell	2005	16325577	A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.
11	Fazi et al.	Cancer Cell	2007	17996649	Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.
12	Li et al.	Nat. Immunol.	2010	20711193	MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
13	Eto et al.	Int. J. Cancer	2015	25159729	The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway.
14	Zhou et al.	J. Exp. Clin. Cancer Res.	2015	25888377	MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7.
15	Li et al.	J. Cancer Res. Clin. Oncol.	2012	22270966	MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4.
16	Wu et al.	PLoS ONE	2013	24324762	Decoy oligonucleotide rescues IGF1R expression from MicroRNA-223 suppression.
17	Pan et al.	J. Immunol.	2014	24307738	Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor.
18	Lu et al.	Clin. Exp. Immunol.	2014	24816316	Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production.
19	Jia et al.	PLoS ONE	2011	22073238	MiR-223 suppresses cell proliferation by targeting IGF-1R.
20	Sun et al.	Nucleic Acids Res.	2012	22080513	Interplay between HIV-1 infection and host microRNAs.
21	Li et al.	Mol. Cancer Res.	2011	21628394	miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3.
22	Lu et al.	Cardiovasc. Res.	2010	20080987	MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism.
23	Li et al.	J. Biomed. Sci.	2011	21453483	miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma.
24	Wu et al.	FEBS Lett.	2012	22569260	MicroRNA-223 regulates FOXO1 expression and cell proliferation.
25	Li et al.	Cell. Physiol. Biochem.	2012	23208072	Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma.
26	Wang et al.	Mol. Cell. Biol.	2013	23459944	MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition.
27	Streppel et al.	Clin. Cancer Res.	2013	23757351	MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1.
28	Nian et al.	Oncol Lett	2013	24137330	miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2.
29	Xu et al.	Biomed. Pharmacother.	2013	23601845	MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation.
30	Agatheeswaran et al.	Leukemia	2013	23174904	BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia.
31	Mansour et al.	J. Exp. Med.	2013	23857984	The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
32	Liang et al.	Int. J. Radiat. Oncol. Biol. Phys.	2014	24606854	MicroRNA-223 enhances radiation sensitivity of U87MG cells in vitro and in vivo by targeting ataxia telangiectasia mutated.
33	Takahashi et al.	Pharm. Res.	2014	24078287	Regulation of cytochrome b5 expression by miR-223 in human liver: effects on cytochrome P450 activities.
34	McGirt et al.	J. Invest. Dermatol.	2014	24304814	miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.
35	Liang et al.	J. Exp. Clin. Cancer Res.	2014	24438193	The downregulation of PRDM1/Blimp-1 is associated with aberrant expression of miR-223 in extranodal NK/T-cell lymphoma, nasal type.
36	Lu et al.	PLoS ONE	2012	22815788	MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets.
37	Lipchina et al.	Genes Dev.	2011	22012620	Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
38	Kishore et al.	Nat. Methods	2011	21572407	A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
39	Pinatel et al.	PLoS ONE	2014	24400121	miR-223 is a coordinator of breast cancer progression as revealed by bioinformatics predictions.
40	Vu et al.	Cell Rep	2013	24332853	PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
41	Dorhoi et al.	J. Clin. Invest.	2013	24084739	MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
42	Yang et al.	Exp. Biol. Med. (Maywood)	2013	23925649	MiR-223 modulates multidrug resistance via downregulation of ABCB1 in hepatocellular carcinoma cells.
43	Gong et al.	Biomed. Pharmacother.	2013	23953883	Caprin-1 is a novel microRNA-223 target for regulating the proliferation and invasion of human breast cancer cells.
44	Huang et al.	Oncol. Rep.	2013	23970099	microRNA-223 promotes the growth and invasion of glioblastoma cells by targeting tumor suppressor PAX6.
45	Oglesby et al.	J. Immunol.	2013	23436935	Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium.
46	Gottwein et al.	Cell Host Microbe	2011	22100165	Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
47	Whisnant et al.	MBio	2013	23592263	In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
48	Farazi et al.	Genome Biol.	2014	24398324	Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
49	Hafner et al.	Cell	2010	20371350	Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
50	Memczak et al.	Nature	2013	23446348	Circular RNAs are a large class of animal RNAs with regulatory potency.
51	Karginov et al.	Genes Dev.	2013	23824327	Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
52	Xue et al.	Cell	2013	23313552	Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.

Targets miRBase

hsa-miR-223-3p (MIMAT0000280) (83 targets) in miRTarBase

References