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hsa-miR-223-3p (MIMAT0000280) (83 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-223-3p Hnf1a
qRT-PCR [1]
Immunocytochemistry [1]
hsa-miR-223-3p STMN1
qRT-PCR [2] [3] [4]
Western blot [4] [2] [3]
Luciferase reporter assay [2] [3] [4]
Flow cytometry [4]
Immunohistochemistry [4]
hsa-miR-223-3p LMO2
qRT-PCR [5]
Reporter assay [6]
Western blot [5]
Luciferase reporter assay [5]
hsa-miR-223-3p E2F1
Western blot [7]
Luciferase reporter assay [7]
hsa-miR-223-3p NFIX
Luciferase reporter assay [8]
hsa-miR-223-3p NFIA
qRT-PCR [9] [10]
microarray [9]
Reporter assay [10]
Western blot [10]
Luciferase reporter assay [10] [11]
hsa-miR-223-3p CHUK
qRT-PCR [12]
Western blot [12]
Luciferase reporter assay [12]
hsa-miR-223-3p FBXW7
qRT-PCR [13] [14] [15]
microarray [15]
Western blot [13] [14] [15]
Luciferase reporter assay [16] [15] [13] [14]
Flow cytometry [15] [13]
hsa-miR-223-3p IGF1R
qRT-PCR [17] [18]
microarray [18]
Western blot [19] [17] [18]
Luciferase reporter assay [16] [19]
hsa-miR-223-3p LIF
Western blot [20]
Luciferase reporter assay [20]
hsa-miR-223-3p SP3
Western blot [20]
Luciferase reporter assay [20]
hsa-miR-223-3p EPB41L3
Western blot [21]
Luciferase reporter assay [21]
hsa-miR-223-3p SLC2A4
Northern blot [22]
qRT-PCR [22]
In situ hybridization [22]
Immunofluorescence [22]
Immunoblot [22]
Luciferase reporter assay [22]
Immunoprecipitaion [22]
Flow cytometry [22]
Immunohistochemistry [22]
hsa-miR-223-3p ARTN
qRT-PCR [23]
Western blot [23]
Luciferase reporter assay [23]
hsa-miR-223-3p FOXO1
qRT-PCR [24]
Western blot [24]
Immunocytochemistry [24]
Luciferase reporter assay [16] [24]
Flow cytometry [24]
hsa-miR-223-3p HSP90B1
Luciferase reporter assay [25]
hsa-miR-223-3p SCARB1
Luciferase reporter assay [26]
hsa-miR-223-3p PARP1
qRT-PCR [27]
microarray [27]
Western blot [27]
Luciferase reporter assay [27]
hsa-miR-223-3p SMARCD1
qRT-PCR [27]
microarray [27]
hsa-miR-223-3p CDK2
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
Flow cytometry [28]
hsa-miR-223-3p ECT2
Western blot [29]
Luciferase reporter assay [29]
hsa-miR-223-3p PTBP2
qRT-PCR [30]
Luciferase reporter assay [30]
hsa-miR-223-3p TAL1
microarray [31]
ChIP [31]
Western blot [31]
hsa-miR-223-3p ATM
qRT-PCR [32]
Western blot [32]
Luciferase reporter assay [32]
hsa-miR-223-3p CYB5A
qRT-PCR [33]
Western blot [33]
Luciferase reporter assay [33]
hsa-miR-223-3p TOX
qRT-PCR [34]
Western blot [34]
Luciferase reporter assay [34]
Immunohistochemistry [34]
hsa-miR-223-3p PRDM1
qRT-PCR [35] [36]
microarray [35]
Western blot [36]
Luciferase reporter assay [36]
hsa-miR-223-3p SEPT2
PAR-CLIP [37]
hsa-miR-223-3p MSMO1
qRT-PCR [35]
microarray [35]
PAR-CLIP [38]
hsa-miR-223-3p NAMPT
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p SNX24
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p CDS1
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p SECISBP2L
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p TWF1
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p ZNF365
qRT-PCR [35]
microarray [35]
hsa-miR-223-3p STAT5A
qRT-PCR [39]
Luciferase reporter assay [39]
hsa-miR-223-3p CARM1
qRT-PCR [40]
ChIP [40]
Western blot [40]
Luciferase reporter assay [40]
Flow cytometry [40]
hsa-miR-223-3p POLR3G
Luciferase reporter assay [16]
hsa-miR-223-3p FOXO3
Luciferase reporter assay [16]
hsa-miR-223-3p CDC27
Luciferase reporter assay [16]
hsa-miR-223-3p SP1
Luciferase reporter assay [16]
hsa-miR-223-3p CCL3
Luciferase reporter assay [41]
hsa-miR-223-3p IL6
Luciferase reporter assay [41]
hsa-miR-223-3p CXCL2
Luciferase reporter assay [41]
hsa-miR-223-3p ABCB1
qRT-PCR [42]
GFP reporter assay [42]
Western blot [42]
hsa-miR-223-3p CAPRIN1
qRT-PCR [43]
Western blot [43]
Luciferase reporter assay [43]
hsa-miR-223-3p PAX6
qRT-PCR [44]
Western blot [44]
Luciferase reporter assay [44]
Immunohistochemistry [44]
hsa-miR-223-3p CFTR
qRT-PCR [45]
Luciferase reporter assay [45]
hsa-miR-223-3p BAG2
PAR-CLIP [46]
hsa-miR-223-3p NSUN3
PAR-CLIP [46]
hsa-miR-223-3p MTRF1L
PAR-CLIP [47]
hsa-miR-223-3p RIF1
PAR-CLIP [47]
hsa-miR-223-3p TP53
PAR-CLIP [47]
hsa-miR-223-3p TMEM64
PAR-CLIP [47]
hsa-miR-223-3p SLC7A5
PAR-CLIP [48] [37] [47]
hsa-miR-223-3p SESN3
PAR-CLIP [47]
hsa-miR-223-3p RRAS2
HITS-CLIP [38]
PAR-CLIP [49] [38] [37] [47]
hsa-miR-223-3p NOVA2
PAR-CLIP [47]
hsa-miR-223-3p LATS2
PAR-CLIP [47]
hsa-miR-223-3p F3
PAR-CLIP [49] [38] [47] [50]
hsa-miR-223-3p MDM2
PAR-CLIP [47]
hsa-miR-223-3p MKNK2
PAR-CLIP [49] [47]
hsa-miR-223-3p IL6ST
PAR-CLIP [37] [47]
hsa-miR-223-3p SPPL2A
PAR-CLIP [38] [48]
hsa-miR-223-3p C9orf40
PAR-CLIP [49] [38] [50]
hsa-miR-223-3p ZBTB18
PAR-CLIP [50] [49]
hsa-miR-223-3p PHF19
PAR-CLIP [50]
hsa-miR-223-3p CHMP2B
PAR-CLIP [50]
hsa-miR-223-3p WASL
PAR-CLIP [50]
hsa-miR-223-3p ARL8B
PAR-CLIP [37]
hsa-miR-223-3p FABP7
PAR-CLIP [37]
hsa-miR-223-3p TMEM67
PAR-CLIP [37]
hsa-miR-223-3p PDZD8
PAR-CLIP [38]
hsa-miR-223-3p FAM60A
PAR-CLIP [49]
hsa-miR-223-3p ITGB1
PAR-CLIP [49]
hsa-miR-223-3p NMNAT2
HITS-CLIP [51]
hsa-miR-223-3p RANGAP1
HITS-CLIP [51]
hsa-miR-223-3p GPATCH8
HITS-CLIP [51]
hsa-miR-223-3p CACNG8
HITS-CLIP [51]
hsa-miR-223-3p ZNF460
HITS-CLIP [52]
hsa-miR-223-3p PAX4
HITS-CLIP [52]
hsa-miR-223-3p HEXIM1
HITS-CLIP [52]
hsa-miR-223-3p TRPV2
HITS-CLIP [38]

References

authors journal year Pubmed link title
1 Li et al. Arthritis Rheum. 2012 22674011 Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223.
2 Masciarelli et al. Oncogene 2014 23584479 Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells.
3 Wong et al. Gastroenterology 2008 18555017 MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.
4 Kang et al. PLoS ONE 2012 22470493 Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer.
5 Felli et al. Haematologica 2009 19278969 MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis.
6 Yuan et al. J. Cell. Mol. Med. 2009 19017354 MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells.
7 Pulikkan et al. Blood 2010 20029046 Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.
8 Sun et al. Nucleic Acids Res. 2010 19850724 Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR.
9 Garzon et al. Oncogene 2007 17260024 MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.
10 Fazi et al. Cell 2005 16325577 A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.
11 Fazi et al. Cancer Cell 2007 17996649 Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.
12 Li et al. Nat. Immunol. 2010 20711193 MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
13 Zhou et al. J. Exp. Clin. Cancer Res. 2015 25888377 MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7.
14 Li et al. J. Cancer Res. Clin. Oncol. 2012 22270966 MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4.
15 Eto et al. Int. J. Cancer 2015 25159729 The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway.
16 Wu et al. PLoS ONE 2013 24324762 Decoy oligonucleotide rescues IGF1R expression from MicroRNA-223 suppression.
17 Pan et al. J. Immunol. 2014 24307738 Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor.
18 Lu et al. Clin. Exp. Immunol. 2014 24816316 Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production.
19 Jia et al. PLoS ONE 2011 22073238 MiR-223 suppresses cell proliferation by targeting IGF-1R.
20 Sun et al. Nucleic Acids Res. 2012 22080513 Interplay between HIV-1 infection and host microRNAs.
21 Li et al. Mol. Cancer Res. 2011 21628394 miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3.
22 Lu et al. Cardiovasc. Res. 2010 20080987 MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism.
23 Li et al. J. Biomed. Sci. 2011 21453483 miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma.
24 Wu et al. FEBS Lett. 2012 22569260 MicroRNA-223 regulates FOXO1 expression and cell proliferation.
25 Li et al. Cell. Physiol. Biochem. 2012 23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma.
26 Wang et al. Mol. Cell. Biol. 2013 23459944 MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition.
27 Streppel et al. Clin. Cancer Res. 2013 23757351 MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1.
28 Nian et al. Oncol Lett 2013 24137330 miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2.
29 Xu et al. Biomed. Pharmacother. 2013 23601845 MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation.
30 Agatheeswaran et al. Leukemia 2013 23174904 BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia.
31 Mansour et al. J. Exp. Med. 2013 23857984 The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
32 Liang et al. Int. J. Radiat. Oncol. Biol. Phys. 2014 24606854 MicroRNA-223 enhances radiation sensitivity of U87MG cells in vitro and in vivo by targeting ataxia telangiectasia mutated.
33 Takahashi et al. Pharm. Res. 2014 24078287 Regulation of cytochrome b5 expression by miR-223 in human liver: effects on cytochrome P450 activities.
34 McGirt et al. J. Invest. Dermatol. 2014 24304814 miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.
35 Lu et al. PLoS ONE 2012 22815788 MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets.
36 Liang et al. J. Exp. Clin. Cancer Res. 2014 24438193 The downregulation of PRDM1/Blimp-1 is associated with aberrant expression of miR-223 in extranodal NK/T-cell lymphoma, nasal type.
37 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
38 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
39 Pinatel et al. PLoS ONE 2014 24400121 miR-223 is a coordinator of breast cancer progression as revealed by bioinformatics predictions.
40 Vu et al. Cell Rep 2013 24332853 PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
41 Dorhoi et al. J. Clin. Invest. 2013 24084739 MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
42 Yang et al. Exp. Biol. Med. (Maywood) 2013 23925649 MiR-223 modulates multidrug resistance via downregulation of ABCB1 in hepatocellular carcinoma cells.
43 Gong et al. Biomed. Pharmacother. 2013 23953883 Caprin-1 is a novel microRNA-223 target for regulating the proliferation and invasion of human breast cancer cells.
44 Huang et al. Oncol. Rep. 2013 23970099 microRNA-223 promotes the growth and invasion of glioblastoma cells by targeting tumor suppressor PAX6.
45 Oglesby et al. J. Immunol. 2013 23436935 Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium.
46 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
47 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
48 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
49 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
50 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
51 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
52 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
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