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hsa-miR-214-3p (MIMAT0000271) (169 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-214-3p EZH2
Northern blot [1]
qRT-PCR [2] [3] [4] [5]
Western blot [5] [2] [4] [3]
Luciferase reporter assay [2] [1] [4] [3] [5]
Flow cytometry [5]
hsa-miR-214-3p PTEN
qRT-PCR [6] [7] [8] [9] [10]
microarray [7]
Reporter assay [10]
Western blot [6] [7] [8] [10] [9]
Other [10]
Immunocytochemistry [6]
Luciferase reporter assay [7] [11] [8] [9] [10]
Flow cytometry [6]
hsa-miR-214-3p DAPK1
qRT-PCR [12]
microarray [12]
hsa-miR-214-3p MAP2K3
qRT-PCR [13]
microarray [13]
GFP reporter assay [13]
Reporter assay [13]
Western blot [13]
Other [13]
hsa-miR-214-3p MAPK8
qRT-PCR [13]
microarray [13]
GFP reporter assay [13]
Reporter assay [13]
Western blot [13]
Other [13]
hsa-miR-214-3p POU4F2
Northern blot [14]
qRT-PCR [14]
GFP reporter assay [14]
Western blot [14]
Flow cytometry [14]
hsa-miR-214-3p PLXNB1
qRT-PCR [15]
microarray [13]
GFP reporter assay [15]
Western blot [15]
Other [13]
Immunohistochemistry [15]
hsa-miR-214-3p SRGAP1
qRT-PCR [16]
In situ hybridization [16]
Western blot [16]
Luciferase reporter assay [16]
hsa-miR-214-3p ING4
qRT-PCR [17]
Luciferase reporter assay [17]
hsa-miR-214-3p XBP1
qRT-PCR [18]
Western blot [18]
Luciferase reporter assay [18]
Flow cytometry [18]
ELISA [18]
hsa-miR-214-3p QKI
Luciferase reporter assay [19]
hsa-miR-214-3p TWIST1
qRT-PCR [20]
Western blot [20]
Luciferase reporter assay [20]
hsa-miR-214-3p GALNT7
microarray [13]
Western blot [21]
Other [13]
Luciferase reporter assay [21]
hsa-miR-214-3p TP53
Reporter assay [22]
Luciferase reporter assay [23]
hsa-miR-214-3p CTNNB1
qRT-PCR [5]
Western blot [5]
Luciferase reporter assay [24] [5]
Flow cytometry [5]
hsa-miR-214-3p ATF4
Luciferase reporter assay [25]
hsa-miR-214-3p BCL2L2
qRT-PCR [26]
Western blot [26]
Luciferase reporter assay [26]
hsa-miR-214-3p FLOT1
microarray [13]
Other [13]
hsa-miR-214-3p MAP2K5
microarray [13]
Other [13]
hsa-miR-214-3p HSPD1
microarray [13]
Other [13]
hsa-miR-214-3p AHSA1
microarray [13]
Other [13]
hsa-miR-214-3p CPNE7
microarray [13]
Other [13]
hsa-miR-214-3p RASA1
microarray [13]
Other [13]
hsa-miR-214-3p YWHAQ
microarray [13]
Other [13]
hsa-miR-214-3p ARL2
microarray [13]
Other [13]
hsa-miR-214-3p AP3B1
microarray [13]
Other [13]
hsa-miR-214-3p SRGAP2
Reporter assay [16]
hsa-miR-214-3p PSMD10
Luciferase reporter assay [27]
hsa-miR-214-3p ASF1B
Luciferase reporter assay [27]
hsa-miR-214-3p MAPK1
qRT-PCR [28]
microarray [28]
Western blot [28]
hsa-miR-214-3p JAG1
qRT-PCR [29]
Western blot [29]
Luciferase reporter assay [29]
hsa-miR-214-3p CCL5
qRT-PCR [30]
Luciferase reporter assay [30]
Immunohistochemistry [30]
ELISA [30]
hsa-miR-214-3p UBE2I
qRT-PCR [31]
Western blot [31]
Luciferase reporter assay [31]
hsa-miR-214-3p HDGF
microarray [32]
Western blot [32]
Luciferase reporter assay [32]
PAR-CLIP [33]
hsa-miR-214-3p FGFR1
qRT-PCR [34] [35]
microarray [35]
In situ hybridization [35]
Western blot [35]
Luciferase reporter assay [34] [35]
hsa-miR-214-3p NRAS
qRT-PCR [36]
Western blot [36]
Luciferase reporter assay [36]
hsa-miR-214-3p BCL2L11
qRT-PCR [37]
Western blot [37]
Luciferase reporter assay [37]
hsa-miR-214-3p WDR81
PAR-CLIP [38]
hsa-miR-214-3p PNPLA6
PAR-CLIP [33]
hsa-miR-214-3p TBPL1
PAR-CLIP [39] [38] [33]
hsa-miR-214-3p PIM1
qRT-PCR [40]
microarray [40]
PAR-CLIP [39]
hsa-miR-214-3p ZBTB33
PAR-CLIP [38] [33]
hsa-miR-214-3p SCAMP4
PAR-CLIP [41]
hsa-miR-214-3p TNFSF9
PAR-CLIP [33]
hsa-miR-214-3p NCOA3
PAR-CLIP [42]
hsa-miR-214-3p ASH1L
HITS-CLIP [43]
hsa-miR-214-3p PAFAH1B2
PAR-CLIP [39] [41]
hsa-miR-214-3p BCL2L2-PABPN1
PAR-CLIP [33]
hsa-miR-214-3p PABPN1
PAR-CLIP [33]
hsa-miR-214-3p SOCS5
PAR-CLIP [33]
hsa-miR-214-3p CRKL
PAR-CLIP [38]
hsa-miR-214-3p CDK6
qRT-PCR [44]
Western blot [44]
Luciferase reporter assay [44]
Immunoprecipitaion [44]
Immunohistochemistry [44]
PAR-CLIP [39] [41] [38]
hsa-miR-214-3p ABLIM3
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p DOCK9
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p ARHGAP10
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p TRPS1
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p CPEB4
qRT-PCR [40]
microarray [40]
PAR-CLIP [45]
hsa-miR-214-3p RAB5B
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p CAPN5
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p TWF1
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p KIF1B
qRT-PCR [40]
microarray [40]
hsa-miR-214-3p LTF
Luciferase reporter assay [46]
hsa-miR-214-3p RAB15
Western blot [47]
Luciferase reporter assay [47]
hsa-miR-214-3p POR
Luciferase reporter assay [48]
hsa-miR-214-3p GSR
Luciferase reporter assay [48]
hsa-miR-214-3p BAX
Luciferase reporter assay [49]
hsa-miR-214-3p CD274
qRT-PCR [50]
Luciferase reporter assay [50]
hsa-miR-214-3p ALPK2
qRT-PCR [44]
Western blot [44]
Luciferase reporter assay [44]
Immunoprecipitaion [44]
Immunohistochemistry [44]
hsa-miR-214-3p PAPPA
qRT-PCR [44]
Western blot [44]
Luciferase reporter assay [44]
Immunoprecipitaion [44]
Immunohistochemistry [44]
hsa-miR-214-3p LZTS1
qRT-PCR [51]
Western blot [51]
Luciferase reporter assay [51]
hsa-miR-214-3p CADM1
Luciferase reporter assay [52]
hsa-miR-214-3p PCBD2
PAR-CLIP [45]
hsa-miR-214-3p CPSF2
PAR-CLIP [45]
hsa-miR-214-3p TNFSF15
PAR-CLIP [45]
hsa-miR-214-3p FAM49B
PAR-CLIP [45]
hsa-miR-214-3p LRTM2
PAR-CLIP [33]
hsa-miR-214-3p TRAF1
PAR-CLIP [33]
hsa-miR-214-3p C9orf78
PAR-CLIP [33]
hsa-miR-214-3p LDB1
PAR-CLIP [33]
hsa-miR-214-3p ERC1
PAR-CLIP [33]
hsa-miR-214-3p TSEN54
PAR-CLIP [33]
hsa-miR-214-3p GABARAP
PAR-CLIP [33]
hsa-miR-214-3p ZNF641
PAR-CLIP [33]
hsa-miR-214-3p FGFR4
PAR-CLIP [33]
hsa-miR-214-3p LAMA4
PAR-CLIP [33]
hsa-miR-214-3p TPM3
PAR-CLIP [39] [41] [33]
hsa-miR-214-3p TFAP2A
PAR-CLIP [39] [41] [38] [33]
hsa-miR-214-3p TAF1D
PAR-CLIP [38] [33] [39]
hsa-miR-214-3p STX6
PAR-CLIP [33]
hsa-miR-214-3p SIK1
PAR-CLIP [33]
hsa-miR-214-3p SHOC2
PAR-CLIP [39] [38] [33]
hsa-miR-214-3p SH3BP4
PAR-CLIP [33]
hsa-miR-214-3p KMT5A
PAR-CLIP [33]
hsa-miR-214-3p PCGF3
PAR-CLIP [33]
hsa-miR-214-3p NFIC
PAR-CLIP [33]
hsa-miR-214-3p MTHFD2
PAR-CLIP [33]
hsa-miR-214-3p KLF16
PAR-CLIP [33]
hsa-miR-214-3p RUBCN
PAR-CLIP [33]
hsa-miR-214-3p KCTD15
PAR-CLIP [33]
hsa-miR-214-3p HEYL
PAR-CLIP [33] [53]
hsa-miR-214-3p GNAL
HITS-CLIP [38]
PAR-CLIP [41] [38] [33]
hsa-miR-214-3p CS
PAR-CLIP [33]
hsa-miR-214-3p CDC42SE1
PAR-CLIP [33]
hsa-miR-214-3p CALU
PAR-CLIP [33]
hsa-miR-214-3p C17orf49
PAR-CLIP [33]
hsa-miR-214-3p C10orf76
PAR-CLIP [33]
hsa-miR-214-3p ARL8B
PAR-CLIP [33]
hsa-miR-214-3p AMER1
PAR-CLIP [41] [38] [33] [42]
hsa-miR-214-3p AGO2
PAR-CLIP [33]
hsa-miR-214-3p ABCC6
PAR-CLIP [41] [33]
hsa-miR-214-3p UBE2V1
PAR-CLIP [39] [41] [38] [33]
hsa-miR-214-3p TMEM189-UBE2V1
PAR-CLIP [39] [41] [38] [33]
hsa-miR-214-3p TMEM189
PAR-CLIP [41] [38] [33] [39]
hsa-miR-214-3p PARS2
PAR-CLIP [33]
hsa-miR-214-3p SFMBT2
PAR-CLIP [54] [33]
hsa-miR-214-3p C9orf3
PAR-CLIP [33]
hsa-miR-214-3p BCAM
PAR-CLIP [33]
hsa-miR-214-3p PPM1L
PAR-CLIP [33]
hsa-miR-214-3p FSCN1
PAR-CLIP [33]
hsa-miR-214-3p CASKIN1
PAR-CLIP [33]
hsa-miR-214-3p ZNRF1
PAR-CLIP [53]
hsa-miR-214-3p CD180
PAR-CLIP [55]
hsa-miR-214-3p ZNF417
PAR-CLIP [39] [41] [38]
hsa-miR-214-3p KLHL15
PAR-CLIP [39] [41] [38]
hsa-miR-214-3p CNIH1
PAR-CLIP [39]
hsa-miR-214-3p BCL2L13
PAR-CLIP [41] [39]
hsa-miR-214-3p BTBD19
PAR-CLIP [39]
hsa-miR-214-3p NUFIP2
PAR-CLIP [39] [41]
hsa-miR-214-3p LUZP1
PAR-CLIP [39] [41] [38]
hsa-miR-214-3p BANP
PAR-CLIP [54]
hsa-miR-214-3p MPDU1
PAR-CLIP [54]
hsa-miR-214-3p CNNM2
PAR-CLIP [54]
hsa-miR-214-3p RLIM
PAR-CLIP [38]
hsa-miR-214-3p LIN7C
PAR-CLIP [38]
hsa-miR-214-3p PHLPP2
PAR-CLIP [38]
hsa-miR-214-3p NPTN
PAR-CLIP [38]
hsa-miR-214-3p HIGD1A
PAR-CLIP [41] [38]
hsa-miR-214-3p ENTPD1
PAR-CLIP [38]
hsa-miR-214-3p SMDT1
PAR-CLIP [41]
hsa-miR-214-3p VAV2
PAR-CLIP [41]
hsa-miR-214-3p ERGIC2
PAR-CLIP [41]
hsa-miR-214-3p AHNAK2
PAR-CLIP [41]
hsa-miR-214-3p TRIM29
PAR-CLIP [41]
hsa-miR-214-3p RPL7L1
PAR-CLIP [41]
hsa-miR-214-3p POLQ
PAR-CLIP [41]
hsa-miR-214-3p FOXI2
HITS-CLIP [56]
hsa-miR-214-3p ABCC12
HITS-CLIP [56]
hsa-miR-214-3p ADRA2B
HITS-CLIP [56]
hsa-miR-214-3p IPP
HITS-CLIP [56]
hsa-miR-214-3p ZBTB10
HITS-CLIP [56]
hsa-miR-214-3p PPARGC1B
HITS-CLIP [56]
hsa-miR-214-3p RASSF4
HITS-CLIP [56]
hsa-miR-214-3p JAG2
HITS-CLIP [56]
hsa-miR-214-3p SUGT1
HITS-CLIP [43] [56]
hsa-miR-214-3p FLOT2
HITS-CLIP [43]
hsa-miR-214-3p NAP1L4
HITS-CLIP [43]
hsa-miR-214-3p TMEM248
HITS-CLIP [43]
hsa-miR-214-3p GDPD5
HITS-CLIP [43]
hsa-miR-214-3p MED23
HITS-CLIP [57]
hsa-miR-214-3p HOMER2
HITS-CLIP [57]
hsa-miR-214-3p TMED9
HITS-CLIP [57]
hsa-miR-214-3p PIGQ
HITS-CLIP [57]
hsa-miR-214-3p SLC39A11
HITS-CLIP [57]
hsa-miR-214-3p TFAP2C
HITS-CLIP [57]
hsa-miR-214-3p ZBTB8B
HITS-CLIP [57]
hsa-miR-214-3p LDLRAD4
HITS-CLIP [57]
hsa-miR-214-3p DKK3
HITS-CLIP [57]
hsa-miR-214-3p INSIG1
HITS-CLIP [57]
hsa-miR-214-3p NCAN
HITS-CLIP [57]

References

authors journal year Pubmed link title
1 Juan et al. Mol. Cell 2009 19818710 Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells.
2 Yang et al. Biochem. Biophys. Res. Commun. 2013 23727574 MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2.
3 Derfoul et al. Carcinogenesis 2011 21828058 Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase.
4 Yang et al. J. Surg. Res. 2014 25085702 Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo.
5 Xia et al. PLoS ONE 2012 22962603 MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma.
6 Xiong et al. Pathol. Oncol. Res. 2011 21688200 Down-regulated miRNA-214 induces a cell cycle G1 arrest in gastric cancer cells by up-regulating the PTEN protein.
7 Jindra et al. J. Immunol. 2010 20548023 Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten.
8 Yang et al. Cancer Cell Int. 2013 23834902 MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN.
9 Li et al. J. Immunol. 2011 21228352 Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes.
10 Yang et al. Cancer Res. 2008 18199536 MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
11 Wang et al. Asian Pac. J. Cancer Prev. 2012 22502680 MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines.
12 Merkerova et al. Stem Cells Dev. 2010 19435428 MicroRNA expression profiles in umbilical cord blood cell lineages.
13 Yang et al. IUBMB Life 2009 19859982 MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells.
14 Calissano et al. Mol. Cell. Neurosci. 2010 20609388 Cell-specific regulation of the pro-survival Brn-3b transcription factor by microRNAs.
15 Qiang et al. Int. J. Biochem. Cell Biol. 2011 21216304 Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells.
16 Zhang et al. Brain Res. 2011 21276775 MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection.
17 Zhang et al. J Hematol Oncol 2010 21106054 Dysregulation of miR-15a and miR-214 in human pancreatic cancer.
18 Duan et al. PLoS ONE 2012 22359598 ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer.
19 van Mil et al. Cardiovasc. Res. 2012 22227154 MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.
20 Li et al. FEBS J. 2012 22540680 Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist.
21 Peng et al. J. Biol. Chem. 2012 22399294 MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7.
22 Xiao et al. EMBO J. 2011 21217645 miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress.
23 Xu et al. J. Biol. Chem. 2012 22927443 MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog.
24 Wang et al. Biochem. Biophys. Res. Commun. 2012 23068095 MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin.
25 Wang et al. Nat. Med. 2013 23223004 miR-214 targets ATF4 to inhibit bone formation.
26 Wang et al. FEBS Lett. 2013 23337879 MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells.
27 Misiewicz-Krzeminska et al. Haematologica 2013 23100276 Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication.
28 Salim et al. Br. J. Cancer 2012 22929890 miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence.
29 Ahluwalia et al. RNA Biol 2012 22336710 Modeling SNP mediated differential targeting of homologous 3'UTR by microRNA.
30 Mitra et al. Cancer Discov 2012 23171795 MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
31 Zhao et al. BMB Rep 2012 23187003 microRNA-214-mediated UBC9 expression in glioma.
32 Shih et al. J. Hepatol. 2012 22613005 MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma.
33 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
34 Wang et al. Biochem. Biophys. Res. Commun. 2013 23962428 Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis.
35 Chen et al. Hepatology 2014 24616020 Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression.
36 Huang et al. Oncotarget 2014 24811402 MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis.
37 Zhang et al. PLoS ONE 2014 24465927 Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma.
38 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
39 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
40 Lu et al. PLoS ONE 2012 22815788 MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets.
41 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
42 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
43 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
44 Salim et al. Genes Chromosomes Cancer 2013 23929716 miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
45 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
46 Deng et al. Tumour Biol. 2013 23479198 miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma.
47 Liu et al. PLoS ONE 2013 24386085 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.
48 Dong et al. Alcohol. Clin. Exp. Res. 2014 23905773 MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells.
49 Yan et al. PLoS ONE 2013 23408966 Isoflurane increases neuronal cell death vulnerability by downregulating miR-214.
50 Nygren et al. Br. J. Cancer 2014 24577056 Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c.
51 Xu et al. Biochem. Biophys. Res. Commun. 2014 24802407 miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.
52 Momose et al. Genes Cells 2013 23301758 miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.
53 Majoros et al. Nat. Methods 2013 23708386 MicroRNA target site identification by integrating sequence and binding information.
54 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
55 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
56 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
57 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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