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hsa-miR-182-5p (MIMAT0000259) (154 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-182-5p FOXO3
Western blot [1]
Luciferase reporter assay [1] [2]
hsa-miR-182-5p FOXO1
qRT-PCR [3] [4]
microarray [4]
Western blot [3]
Luciferase reporter assay [3]
Immunohistochemistry [4]
PAR-CLIP [5]
hsa-miR-182-5p RARG
Western blot [6]
Luciferase reporter assay [6]
hsa-miR-182-5p MITF
qRT-PCR [7]
Western blot [7]
Luciferase reporter assay [8] [7]
Flow cytometry [7]
hsa-miR-182-5p ADCY6
qRT-PCR [9]
Luciferase reporter assay [8] [9]
hsa-miR-182-5p EP300
microarray [10]
hsa-miR-182-5p CLOCK
qRT-PCR [9]
Luciferase reporter assay [9]
hsa-miR-182-5p TSC22D3
qRT-PCR [9]
Luciferase reporter assay [9]
hsa-miR-182-5p CREB1
GFP reporter assay [11]
hsa-miR-182-5p MTSS1
Luciferase reporter assay [12] [13] [14] [15]
hsa-miR-182-5p FGF9
Western blot [16]
Luciferase reporter assay [16]
hsa-miR-182-5p NTM
Western blot [16]
Luciferase reporter assay [16]
hsa-miR-182-5p CYLD
qRT-PCR [17]
Western blot [17]
Luciferase reporter assay [17]
hsa-miR-182-5p BCL2
qRT-PCR [7] [18]
Western blot [7]
Luciferase reporter assay [7]
Flow cytometry [7]
hsa-miR-182-5p CCND2
qRT-PCR [7]
Western blot [7]
Luciferase reporter assay [7]
Flow cytometry [7]
hsa-miR-182-5p PDCD4
qRT-PCR [19]
Western blot [19]
Luciferase reporter assay [19] [20]
hsa-miR-182-5p PFN1
Luciferase reporter assay [21]
PAR-CLIP [22] [23] [24] [5]
hsa-miR-182-5p SNAI2
Luciferase reporter assay [25]
hsa-miR-182-5p RECK
qRT-PCR [26]
Western blot [26]
Luciferase reporter assay [14] [27] [26]
PAR-CLIP [24]
hsa-miR-182-5p SMAD4
Luciferase reporter assay [27]
hsa-miR-182-5p FOXF2
Luciferase reporter assay [14]
hsa-miR-182-5p IGF1R
PAR-CLIP [24]
hsa-miR-182-5p CISD2
CLASH [28]
hsa-miR-182-5p BRIP1
CLASH [28]
hsa-miR-182-5p RBM12
CLASH [28]
hsa-miR-182-5p CBX6
CLASH [28]
hsa-miR-182-5p FMNL3
CLASH [28]
hsa-miR-182-5p RPL5
CLASH [28]
hsa-miR-182-5p RCC2
CLASH [28]
hsa-miR-182-5p GNL1
CLASH [28]
hsa-miR-182-5p SNRPA1
CLASH [28]
hsa-miR-182-5p C1orf174
CLASH [28]
hsa-miR-182-5p RLF
CLASH [28]
hsa-miR-182-5p CASC3
CLASH [28]
hsa-miR-182-5p FLOT1
qRT-PCR [29]
Western blot [29]
Luciferase reporter assay [29]
Immunohistochemistry [29]
CLASH [28]
hsa-miR-182-5p BAG1
CLASH [28]
hsa-miR-182-5p RBM15B
CLASH [28]
hsa-miR-182-5p LSM14A
CLASH [28]
hsa-miR-182-5p RPS4X
CLASH [28]
hsa-miR-182-5p UBA1
CLASH [28]
hsa-miR-182-5p RPS3
CLASH [28]
hsa-miR-182-5p CENPS
CLASH [28]
hsa-miR-182-5p TMEM184C
CLASH [28]
hsa-miR-182-5p ETV3
CLASH [28]
hsa-miR-182-5p SEC61A2
CLASH [28]
hsa-miR-182-5p UBP1
CLASH [28]
hsa-miR-182-5p USP16
CLASH [28]
hsa-miR-182-5p ACVR1B
CLASH [28]
hsa-miR-182-5p STAG2
CLASH [28]
hsa-miR-182-5p RAB3IP
CLASH [28]
hsa-miR-182-5p ATP5O
CLASH [28]
hsa-miR-182-5p SLC25A14
CLASH [28]
hsa-miR-182-5p TTC28
CLASH [28]
hsa-miR-182-5p NUFIP2
CLASH [28]
hsa-miR-182-5p TNKS1BP1
CLASH [28]
hsa-miR-182-5p ACTN4
CLASH [28]
hsa-miR-182-5p TUBA1B
CLASH [28]
hsa-miR-182-5p EVI5
PAR-CLIP [22]
CLASH [28]
hsa-miR-182-5p VPS51
CLASH [28]
hsa-miR-182-5p ANO6
CLASH [28]
hsa-miR-182-5p PCOLCE2
CLASH [28]
hsa-miR-182-5p LBR
CLASH [28]
hsa-miR-182-5p PIK3C2A
CLASH [28]
hsa-miR-182-5p ERO1A
CLASH [28]
hsa-miR-182-5p PRKAA2
CLASH [28]
hsa-miR-182-5p ATP13A3
CLASH [28]
hsa-miR-182-5p PTEN
qRT-PCR [30]
microarray [30]
Western blot [30]
Luciferase reporter assay [30]
hsa-miR-182-5p GSK3B
qRT-PCR [31]
microarray [31]
Western blot [31]
Luciferase reporter assay [31]
Immunohistochemistry [31]
hsa-miR-182-5p ZFAND4
qRT-PCR [32]
microarray [32]
Immunofluorescence [32]
Western blot [32]
Luciferase reporter assay [32]
Immunohistochemistry [32]
hsa-miR-182-5p BDNF
qRT-PCR [33]
Western blot [33]
hsa-miR-182-5p SATB2
qRT-PCR [34]
Western blot [34]
Luciferase reporter assay [34]
hsa-miR-182-5p CHL1
qRT-PCR [35]
Western blot [35]
Luciferase reporter assay [35]
hsa-miR-182-5p CADM1
qRT-PCR [36]
Western blot [36]
Luciferase reporter assay [36]
hsa-miR-182-5p TP53INP1
qRT-PCR [37]
Western blot [37]
Luciferase reporter assay [37]
hsa-miR-182-5p NOTCH2
HITS-CLIP [38]
hsa-miR-182-5p BRWD1
HITS-CLIP [39]
hsa-miR-182-5p QSER1
PAR-CLIP [24]
hsa-miR-182-5p NUP50
PAR-CLIP [40]
hsa-miR-182-5p ATF1
Luciferase reporter assay [41]
hsa-miR-182-5p BARD1
Luciferase reporter assay [41]
hsa-miR-182-5p CREB5
Luciferase reporter assay [41]
hsa-miR-182-5p RAD17
Luciferase reporter assay [41]
hsa-miR-182-5p TP53BP1
Luciferase reporter assay [41]
hsa-miR-182-5p CHEK2
Luciferase reporter assay [41]
hsa-miR-182-5p CDKN1B
Luciferase reporter assay [41]
hsa-miR-182-5p SMARCD3
Luciferase reporter assay [41]
hsa-miR-182-5p TCEAL7
qRT-PCR [42]
Western blot [42]
Luciferase reporter assay [42]
hsa-miR-182-5p FBXW7
Western blot [43]
Luciferase reporter assay [43]
hsa-miR-182-5p LRRC4
qRT-PCR [44]
Luciferase reporter assay [44]
Immunohistochemistry [44]
hsa-miR-182-5p NDRG1
Luciferase reporter assay [45]
hsa-miR-182-5p THBS1
Luciferase reporter assay [46]
hsa-miR-182-5p ULBP2
qRT-PCR [47]
Western blot [47]
Luciferase reporter assay [47]
hsa-miR-182-5p CTNNA3
PAR-CLIP [48]
hsa-miR-182-5p RASA2
PAR-CLIP [48]
hsa-miR-182-5p GPR156
PAR-CLIP [49]
hsa-miR-182-5p PITPNM3
PAR-CLIP [49]
hsa-miR-182-5p STOML3
PAR-CLIP [49]
hsa-miR-182-5p SIN3B
PAR-CLIP [49]
hsa-miR-182-5p SERPINH1
PAR-CLIP [49]
hsa-miR-182-5p PPP1R11
PAR-CLIP [49]
hsa-miR-182-5p KLHL28
PAR-CLIP [40] [24] [49]
hsa-miR-182-5p ATXN1L
PAR-CLIP [49]
hsa-miR-182-5p CCL22
PAR-CLIP [49]
hsa-miR-182-5p MBD4
PAR-CLIP [24] [22]
hsa-miR-182-5p CASTOR2
PAR-CLIP [22]
hsa-miR-182-5p ACER2
PAR-CLIP [22]
hsa-miR-182-5p RPL7L1
PAR-CLIP [23] [40] [24]
hsa-miR-182-5p SESN2
PAR-CLIP [23]
hsa-miR-182-5p RPS23
PAR-CLIP [23] [40]
hsa-miR-182-5p SYNM
PAR-CLIP [5]
hsa-miR-182-5p MALT1
PAR-CLIP [5]
hsa-miR-182-5p UBE2D4
PAR-CLIP [40] [5]
hsa-miR-182-5p TRIM71
PAR-CLIP [5]
hsa-miR-182-5p TNRC6A
PAR-CLIP [5]
hsa-miR-182-5p PODXL
PAR-CLIP [5]
hsa-miR-182-5p MORF4L1
PAR-CLIP [24]
hsa-miR-182-5p ECHDC1
PAR-CLIP [24]
hsa-miR-182-5p INCENP
PAR-CLIP [40] [24]
hsa-miR-182-5p SYDE2
PAR-CLIP [24]
hsa-miR-182-5p PPP1R12A
PAR-CLIP [24]
hsa-miR-182-5p PNISR
PAR-CLIP [24]
hsa-miR-182-5p NUP43
PAR-CLIP [24]
hsa-miR-182-5p MAP3K3
PAR-CLIP [24]
hsa-miR-182-5p HOXA9
PAR-CLIP [24]
hsa-miR-182-5p CRAMP1
PAR-CLIP [24]
hsa-miR-182-5p MIGA1
PAR-CLIP [24]
hsa-miR-182-5p DDAH1
PAR-CLIP [24]
hsa-miR-182-5p CITED2
PAR-CLIP [24]
hsa-miR-182-5p TNFRSF10A
PAR-CLIP [40]
hsa-miR-182-5p TMEM170B
PAR-CLIP [40]
hsa-miR-182-5p SYNGR2
PAR-CLIP [40]
hsa-miR-182-5p TUBD1
PAR-CLIP [40]
hsa-miR-182-5p LZIC
PAR-CLIP [40]
hsa-miR-182-5p PLEKHA8
HITS-CLIP [38]
hsa-miR-182-5p GID4
HITS-CLIP [50] [39] [38]
hsa-miR-182-5p NPTX1
HITS-CLIP [38]
hsa-miR-182-5p GABRB1
HITS-CLIP [38]
hsa-miR-182-5p SLC11A1
HITS-CLIP [38]
hsa-miR-182-5p STK17B
HITS-CLIP [38]
hsa-miR-182-5p CPE
HITS-CLIP [38]
hsa-miR-182-5p IPP
HITS-CLIP [38]
hsa-miR-182-5p ANKRD36
HITS-CLIP [38]
hsa-miR-182-5p ZNF831
HITS-CLIP [38]
hsa-miR-182-5p TRAPPC3L
HITS-CLIP [38]
hsa-miR-182-5p PPM1L
HITS-CLIP [38]
hsa-miR-182-5p KDM5A
HITS-CLIP [38]
hsa-miR-182-5p EIF4EBP2
HITS-CLIP [38]
hsa-miR-182-5p GK5
HITS-CLIP [38]
hsa-miR-182-5p EXOSC2
HITS-CLIP [38]
hsa-miR-182-5p NR3C1
HITS-CLIP [39]
hsa-miR-182-5p ZNF185
HITS-CLIP [39]
hsa-miR-182-5p ZFAND1
HITS-CLIP [39]
hsa-miR-182-5p USP5
HITS-CLIP [39]
hsa-miR-182-5p FAM193A
HITS-CLIP [50]

References

authors journal year Pubmed link title
1 Segura et al. Proc. Natl. Acad. Sci. U.S.A. 2009 19188590 Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.
2 Xu et al. Int. J. Biochem. Cell Biol. 2013 23262295 The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation.
3 Guttilla et al. J. Biol. Chem. 2009 19574223 Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.
4 Li et al. Int. J. Oncol. 2014 24865442 Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities.
5 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
6 Li et al. Mech. Ageing Dev. 2009 19782699 Alterations in microRNA expression in stress-induced cellular senescence.
7 Yan et al. PLoS ONE 2012 22848417 Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2.
8 Xu et al. J. Biol. Chem. 2007 17597072 MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.
9 Saus et al. Hum. Mol. Genet. 2010 20656788 Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.
10 Mees et al. Int. J. Cancer 2010 19569050 EP300--a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas.
11 Kong et al. FEBS J. 2012 22325466 MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma.
12 Liu et al. J. Pathol. 2012 22322863 MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.
13 Wang et al. BMC Cancer 2012 22681717 MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma.
14 Hirata et al. PLoS ONE 2013 23383207 MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer.
15 Lei et al. Oncogene 2014 23474751 Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis.
16 Yu et al. Nucleic Acids Res. 2012 22917588 miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury.
17 Song et al. J. Clin. Invest. 2012 23006329 TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets.
18 Peng et al. PLoS ONE 2013 23936432 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21.
19 Wang et al. J. Cell. Biochem. 2013 23296900 MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas.
20 Wang et al. Tumour Biol. 2014 23877371 Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells.
21 Liu et al. Tumour Biol. 2013 23430586 Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1.
22 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
23 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
24 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
25 Qu et al. Int. J. Cancer 2013 23354685 MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells.
26 Chiang et al. Biochim. Biophys. Acta 2013 23333633 Up-regulation of miR-182 by β-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK.
27 Hirata et al. PLoS ONE 2012 23226455 Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer.
28 Helwak et al. Cell 2013 23622248 Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
29 Xu et al. Mol. Cancer 2014 24886554 Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway.
30 Li et al. Biotechnol. Lett. 2014 24867318 Inflammation-induced miR-802 promotes cell proliferation in cholesteatoma.
31 Tang et al. Nucleic Acids Res. 2014 24335145 Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells.
32 Tang et al. Oncol. Rep. 2015 25682742 MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer.
33 Li et al. PLoS ONE 2013 23704927 Alterations of serum levels of BDNF-related miRNAs in patients with depression.
34 Yang et al. J Transl Med 2014 24884732 microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis.
35 Zhu et al. Biochem. Biophys. Res. Commun. 2014 24971532 miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.
36 Qiu et al. Mol Biosyst 2014 24445397 TGF-β upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1.
37 Qin et al. Gene 2014 24447717 Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1.
38 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
39 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
40 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
41 Krishnan et al. RNA 2013 23249749 MicroRNA-182-5p targets a network of genes involved in DNA repair.
42 Guo et al. Cell. Physiol. Biochem. 2013 24021963 MicroRNA-182 promotes tumor cell growth by targeting transcription elongation factor A-like 7 in endometrial carcinoma.
43 Li et al. J. Pathol. 2014 25269767 Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma.
44 Tang et al. PLoS ONE 2014 24404152 Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
45 Liu et al. PLoS ONE 2013 23874837 Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1).
46 Amodeo et al. Expert Opin. Ther. Targets 2013 24053448 Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?
47 Zhang et al. Cell Biol. Int. 2013 23956116 A novel recombinant Salmonella vaccine enhances the innate immunity of NK cells against acute myeloid leukaemia cells Kasumi-1 in vitro.
48 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
49 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
50 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
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