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hsa-miR-199a-5p (MIMAT0000231) (133 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-199a-5p Grb10
Luciferase reporter assay [1]
hsa-miR-199a-5p IKBKB
qRT-PCR [2]
GFP reporter assay [2]
Reporter assay [2]
Western blot [2]
Luciferase reporter assay [2]
hsa-miR-199a-5p CCNL1
Northern blot [3]
microarray [4] [3]
hsa-miR-199a-5p LIF
HITS-CLIP [5]
Luciferase reporter assay [6]
ELISA [6]
hsa-miR-199a-5p JUNB
Northern blot [3]
microarray [3]
hsa-miR-199a-5p MED6
Northern blot [3]
microarray [3]
hsa-miR-199a-5p MECP2
Northern blot [3]
microarray [3]
hsa-miR-199a-5p ETS2
Northern blot [3]
microarray [3]
hsa-miR-199a-5p DDR1
qRT-PCR [7]
Western blot [7]
Luciferase reporter assay [7]
hsa-miR-199a-5p EDN1
Luciferase reporter assay [8]
hsa-miR-199a-5p MAP3K11
qRT-PCR [9]
Western blot [9]
Luciferase reporter assay [9]
hsa-miR-199a-5p HIF1A
qRT-PCR [10] [11] [12]
Western blot [10] [11] [12]
Luciferase reporter assay [11] [12]
Immunohistochemistry [10]
hsa-miR-199a-5p SOX9
qRT-PCR [13]
hsa-miR-199a-5p SMARCA2
qRT-PCR [14]
Western blot [14]
Luciferase reporter assay [14]
hsa-miR-199a-5p CD44
Luciferase reporter assay [15]
hsa-miR-199a-5p TMEM54
Northern blot [16]
qRT-PCR [16]
In situ hybridization [16]
Immunoblot [16]
Luciferase reporter assay [16]
hsa-miR-199a-5p SMAD4
Luciferase reporter assay [17] [18]
hsa-miR-199a-5p SULT1E1
Luciferase reporter assay [19]
hsa-miR-199a-5p GPR78
Luciferase reporter assay [20]
hsa-miR-199a-5p ERBB2
qRT-PCR [21]
Western blot [22]
Immunoblot [21]
Luciferase reporter assay [21]
Immunohistochemistry [21]
hsa-miR-199a-5p UNG
Luciferase reporter assay [23]
hsa-miR-199a-5p CAV1
qRT-PCR [24]
microarray [24]
ChIP [24]
Immunofluorescence [24]
Western blot [24]
Luciferase reporter assay [25] [24]
Immunohistochemistry [24]
FACS [24]
hsa-miR-199a-5p SIRT1
qRT-PCR [11] [26]
Western blot [11] [26]
Luciferase reporter assay [11]
hsa-miR-199a-5p HSPA5
qRT-PCR [27]
Western blot [27]
Luciferase reporter assay [27]
hsa-miR-199a-5p ATF6
qRT-PCR [27] [28]
Western blot [27] [28]
Luciferase reporter assay [27] [28]
hsa-miR-199a-5p ERN1
qRT-PCR [27]
Western blot [27]
Luciferase reporter assay [27]
hsa-miR-199a-5p KL
qRT-PCR [29]
In situ hybridization [29]
GFP reporter assay [29]
Immunofluorescence [29]
Western blot [29]
HITS-CLIP [29]
Immunoblot [29]
Immunocytochemistry [29]
Luciferase reporter assay [29]
Flow cytometry [29]
Immunohistochemistry [29]
GUS reporter assay [29]
FACS [29]
EMSA [29]
Gluc reporter assay [29]
hsa-miR-199a-5p APOE
microarray [30]
Luciferase reporter assay [30]
ELISA [30]
hsa-miR-199a-5p DNAJA4
microarray [30]
Luciferase reporter assay [30]
ELISA [30]
hsa-miR-199a-5p ERBB3
qRT-PCR [21]
Immunoblot [21]
Luciferase reporter assay [21]
Immunohistochemistry [21]
hsa-miR-199a-5p CDH1
qRT-PCR [31]
microarray [31]
Immunofluorescence [31]
Western blot [31]
Luciferase reporter assay [31]
Immunoprecipitaion [31]
Immunohistochemistry [31]
hsa-miR-199a-5p PTGS2
Western blot [32]
Luciferase reporter assay [32]
hsa-miR-199a-5p RNF11
PAR-CLIP [33]
hsa-miR-199a-5p ZNF544
PAR-CLIP [34]
hsa-miR-199a-5p TFDP2
HITS-CLIP [35]
hsa-miR-199a-5p ZNF844
PAR-CLIP [34]
hsa-miR-199a-5p PANK3
HITS-CLIP [5]
hsa-miR-199a-5p COL19A1
PAR-CLIP [36]
hsa-miR-199a-5p LIN7A
Luciferase reporter assay [37]
hsa-miR-199a-5p ARHGAP12
Luciferase reporter assay [37]
hsa-miR-199a-5p CTSC
Luciferase reporter assay [37]
hsa-miR-199a-5p RND1
Luciferase reporter assay [37]
hsa-miR-199a-5p NECTIN1
Luciferase reporter assay [37]
hsa-miR-199a-5p DRAM1
Western blot [38]
Luciferase reporter assay [38]
hsa-miR-199a-5p BECN1
Western blot [38]
Luciferase reporter assay [38]
hsa-miR-199a-5p MAFB
Western blot [39]
Luciferase reporter assay [39]
hsa-miR-199a-5p WNK1
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-199a-5p NFKB1
qRT-PCR [28]
Western blot [28]
Luciferase reporter assay [28]
hsa-miR-199a-5p ACVR1B
qRT-PCR [40]
Western blot [40]
Luciferase reporter assay [40]
Immunoprecipitaion [40]
hsa-miR-199a-5p VEGFA
Luciferase reporter assay [41]
hsa-miR-199a-5p CDH2
Western blot [42]
Luciferase reporter assay [42]
hsa-miR-199a-5p SNAI1
Western blot [42]
Luciferase reporter assay [42]
hsa-miR-199a-5p GSK3B
qRT-PCR [24]
microarray [24]
ChIP [24]
Immunofluorescence [24]
Western blot [24]
Luciferase reporter assay [24]
Immunohistochemistry [24]
FACS [24]
hsa-miR-199a-5p FZD4
qRT-PCR [24]
microarray [24]
ChIP [24]
Immunofluorescence [24]
Western blot [24]
Luciferase reporter assay [24]
Immunohistochemistry [24]
FACS [24]
hsa-miR-199a-5p WNT2
qRT-PCR [24]
microarray [24]
ChIP [24]
Immunofluorescence [24]
Western blot [24]
Luciferase reporter assay [24]
Immunohistochemistry [24]
FACS [24]
hsa-miR-199a-5p JAG1
qRT-PCR [24]
microarray [24]
ChIP [24]
Immunofluorescence [24]
Western blot [24]
Luciferase reporter assay [24]
Immunohistochemistry [24]
FACS [24]
hsa-miR-199a-5p PSG11
PAR-CLIP [43]
hsa-miR-199a-5p PSG3
PAR-CLIP [43]
hsa-miR-199a-5p PIN1
PAR-CLIP [44]
hsa-miR-199a-5p C1orf226
PAR-CLIP [44]
hsa-miR-199a-5p PLEKHG2
PAR-CLIP [44]
hsa-miR-199a-5p PDE11A
PAR-CLIP [44]
hsa-miR-199a-5p SNTB1
PAR-CLIP [45] [44]
hsa-miR-199a-5p SLC38A2
PAR-CLIP [45] [44]
hsa-miR-199a-5p SESN2
PAR-CLIP [44]
hsa-miR-199a-5p RER1
PAR-CLIP [44]
hsa-miR-199a-5p PLXND1
PAR-CLIP [44]
hsa-miR-199a-5p MAP3K9
PAR-CLIP [44]
hsa-miR-199a-5p E2F3
PAR-CLIP [44]
hsa-miR-199a-5p COX15
PAR-CLIP [44]
hsa-miR-199a-5p TSC22D1
PAR-CLIP [44]
hsa-miR-199a-5p CEP120
PAR-CLIP [44]
hsa-miR-199a-5p SLC16A10
PAR-CLIP [46]
hsa-miR-199a-5p POLR2F
PAR-CLIP [33] [36]
hsa-miR-199a-5p RCC1
PAR-CLIP [33] [34] [45]
hsa-miR-199a-5p DYNAP
PAR-CLIP [33]
hsa-miR-199a-5p PAX8
PAR-CLIP [33]
hsa-miR-199a-5p EXTL3
PAR-CLIP [33] [36]
hsa-miR-199a-5p ZNF669
PAR-CLIP [33] [34] [45]
hsa-miR-199a-5p ZNF440
PAR-CLIP [33] [34]
hsa-miR-199a-5p ZNF117
PAR-CLIP [33] [34]
hsa-miR-199a-5p ZNF791
PAR-CLIP [33] [34] [45]
hsa-miR-199a-5p ZNF772
PAR-CLIP [33] [34]
hsa-miR-199a-5p ZNF394
PAR-CLIP [33] [34]
hsa-miR-199a-5p TUBG1
PAR-CLIP [33] [34]
hsa-miR-199a-5p NAA15
PAR-CLIP [33] [34] [45]
hsa-miR-199a-5p DDX19B
PAR-CLIP [33]
hsa-miR-199a-5p RIC8A
PAR-CLIP [36]
hsa-miR-199a-5p C3orf36
PAR-CLIP [34] [36]
hsa-miR-199a-5p SNRNP48
PAR-CLIP [36]
hsa-miR-199a-5p PSAPL1
PAR-CLIP [36]
hsa-miR-199a-5p AKAP17A
PAR-CLIP [36]
hsa-miR-199a-5p PLGRKT
PAR-CLIP [36]
hsa-miR-199a-5p TNFRSF13C
PAR-CLIP [36]
hsa-miR-199a-5p SLC8A1
PAR-CLIP [36]
hsa-miR-199a-5p CSGALNACT1
PAR-CLIP [36]
hsa-miR-199a-5p SERPINH1
PAR-CLIP [45]
hsa-miR-199a-5p TMOD2
PAR-CLIP [45]
hsa-miR-199a-5p DDX3X
PAR-CLIP [45]
hsa-miR-199a-5p ZNF525
PAR-CLIP [34]
hsa-miR-199a-5p ZNF195
PAR-CLIP [34]
hsa-miR-199a-5p ZNF415
PAR-CLIP [34]
hsa-miR-199a-5p ZNF468
PAR-CLIP [34]
hsa-miR-199a-5p ZNF611
PAR-CLIP [34]
hsa-miR-199a-5p ZNF215
PAR-CLIP [34]
hsa-miR-199a-5p ZNF286B
PAR-CLIP [34]
hsa-miR-199a-5p ZFP1
PAR-CLIP [34]
hsa-miR-199a-5p ZNF846
PAR-CLIP [34]
hsa-miR-199a-5p ZNF625
PAR-CLIP [34]
hsa-miR-199a-5p ZNF584
PAR-CLIP [34]
hsa-miR-199a-5p TRIM10
PAR-CLIP [34]
hsa-miR-199a-5p VAV3
HITS-CLIP [45] [47]
PAR-CLIP [34]
hsa-miR-199a-5p OXSR1
HITS-CLIP [48]
hsa-miR-199a-5p PLPP4
HITS-CLIP [48]
hsa-miR-199a-5p A2ML1
HITS-CLIP [48]
hsa-miR-199a-5p RNF115
HITS-CLIP [48]
hsa-miR-199a-5p AGTRAP
HITS-CLIP [48]
hsa-miR-199a-5p NDUFS2
HITS-CLIP [48]
hsa-miR-199a-5p CHRFAM7A
HITS-CLIP [48]
hsa-miR-199a-5p CRIPT
HITS-CLIP [48]
hsa-miR-199a-5p POLA2
HITS-CLIP [48]
hsa-miR-199a-5p GATA6
HITS-CLIP [48]
hsa-miR-199a-5p CDK9
HITS-CLIP [35]
hsa-miR-199a-5p VPS53
HITS-CLIP [35]
hsa-miR-199a-5p PTCD2
HITS-CLIP [35]
hsa-miR-199a-5p SLC26A2
HITS-CLIP [35]
hsa-miR-199a-5p PODXL
HITS-CLIP [35]
hsa-miR-199a-5p ABCC1
HITS-CLIP [35]
hsa-miR-199a-5p TBC1D21
HITS-CLIP [5]
hsa-miR-199a-5p CENPO
HITS-CLIP [5]
hsa-miR-199a-5p CHCHD4
HITS-CLIP [5]
hsa-miR-199a-5p LAX1
HITS-CLIP [5]
hsa-miR-199a-5p SNAP25
HITS-CLIP [5]

References

authors journal year Pubmed link title
1 Xia et al. Reproduction 2014 24149516 MiR199a is implicated in embryo implantation by regulating Grb10 in rat.
2 Chen et al. Oncogene 2008 18408758 Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells.
3 Murakami et al. Oncogene 2006 16331254 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.
4 Iorio et al. Cancer Res. 2007 17875710 MicroRNA signatures in human ovarian cancer.
5 Chi et al. Nature 2009 19536157 Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
6 Oskowitz et al. Proc. Natl. Acad. Sci. U.S.A. 2008 19011087 Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.
7 Shen et al. Mol. Cancer 2010 20799954 Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion.
8 Yeligar et al. J. Immunol. 2009 19783678 Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
9 Song et al. Biol. Pharm. Bull. 2010 21048306 miR-199a regulates the tumor suppressor mitogen-activated protein kinase kinase kinase 11 in gastric cancer.
10 Ding et al. Mol. Cell. Biochem. 2013 24022342 MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α.
11 Raimondi et al. Oncotarget 2014 24839982 Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity.
12 Jia et al. Cell Biochem. Biophys. 2012 21847633 Lentivirus-mediated overexpression of microRNA-199a inhibits cell proliferation of human hepatocellular carcinoma.
13 Laine et al. J. Cell. Biochem. 2012 22441842 MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells.
14 Sakurai et al. Cancer Res. 2011 21189327 MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers.
15 Cheng et al. FEBS J. 2012 22498306 MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.
16 Kong et al. Int. J. Biochem. Cell Biol. 2012 22903020 The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer.
17 Zeng et al. FEBS Lett. 2012 22819820 Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3.
18 Zhang et al. Nucleic Acids Res. 2012 22821565 Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.
19 Chan et al. J. Biol. Chem. 2012 23060436 The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway.
20 Su et al. Oncogene 2013 23085757 miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.
21 He et al. EMBO Rep. 2012 23146892 Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
22 He et al. PLoS ONE 2013 23437196 Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis.
23 Hegre et al. DNA Repair (Amst.) 2013 23228472 Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.
24 Alexander et al. Cell Death Differ. 2013 23764775 MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation.
25 Lino Cardenas et al. PLoS Genet. 2013 23459460 miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1.
26 Zhang et al. Arch. Virol. 2013 23760629 MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS.
27 Dai et al. Cell Death Dis 2013 23598416 microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress.
28 Hassan et al. Am. J. Respir. Crit. Care Med. 2014 24299514 miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency.
29 He et al. BMC Cancer 2014 24655788 Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho.
30 Pencheva et al. Cell 2012 23142051 Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.
31 Zhao et al. Cell Death Differ. 2014 25080937 SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancer.
32 He et al. Environ. Health Perspect. 2014 24413338 Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1α/COX-2 pathway.
33 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
34 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
35 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
36 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
37 Monastyrskaya et al. Am. J. Pathol. 2013 23201090 miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome.
38 Yi et al. FEBS Lett. 2013 23337876 Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells.
39 Gu et al. PLoS ONE 2013 24391856 Molecular mechanisms of regulation and action of microRNA-199a in testicular germ cell tumor and glioblastomas.
40 Lin et al. J. Leukoc. Biol. 2014 25258381 miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression.
41 Hsu et al. J. Pathol. 2014 24155090 miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis.
42 Suzuki et al. Genes Cells 2014 25041364 Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a.
43 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
44 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
45 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
46 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
47 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
48 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
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