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hsa-miR-449a (MIMAT0001541) (116 targets) in miRTarBase

miRNA gene name experiments
hsa-miR-449a CDC25A
qRT-PCR [1]
microarray [1]
Reporter assay [1]
Western blot [1]
Other [1]
Luciferase reporter assay [1] [2]
hsa-miR-449a CDK6
qRT-PCR [3] [4] [1]
microarray [1]
ChIP [4]
Reporter assay [1]
Immunofluorescence [3]
Western blot [1] [3] [4]
Other [1]
Luciferase reporter assay [1]
Immunoprecipitaion [4]
Flow cytometry [4]
Immunohistochemistry [4]
PAR-CLIP [5]
hsa-miR-449a HDAC1
qRT-PCR [6]
Reporter assay [6]
Western blot [6] [7]
Other [6]
Immunoblot [8]
Luciferase reporter assay [6] [7]
hsa-miR-449a CCND1
qRT-PCR [9]
Western blot [9]
Immunoblot [8]
Luciferase reporter assay [8] [9]
Flow cytometry [9] [8]
hsa-miR-449a HNF4A
Western blot [10]
Luciferase reporter assay [10] [11]
hsa-miR-449a GMNN
Western blot [7]
Luciferase reporter assay [7]
hsa-miR-449a MET
qRT-PCR [12]
Western blot [7] [12]
Luciferase reporter assay [7] [12]
hsa-miR-449a CCNE2
Western blot [7]
Luciferase reporter assay [7]
PAR-CLIP [13]
hsa-miR-449a SIRT1
Western blot [7]
Luciferase reporter assay [7]
hsa-miR-449a BCL2
qRT-PCR [14] [9] [15]
ChIP [16]
Western blot [14] [9] [15]
Luciferase reporter assay [9] [16] [15]
Flow cytometry [9]
hsa-miR-449a NOTCH1
qRT-PCR [17]
ChIP [16]
Immunofluorescence [17]
Western blot [17]
Luciferase reporter assay [16] [17]
hsa-miR-449a WISP2
Luciferase reporter assay [18]
hsa-miR-449a CDK4
Western blot [1]
hsa-miR-449a LEF1
qRT-PCR [19]
Western blot [19]
Luciferase reporter assay [19]
hsa-miR-449a E2F3
qRT-PCR [20] [21]
Western blot [20] [21]
Luciferase reporter assay [20] [21]
Flow cytometry [21]
PAR-CLIP [22]
hsa-miR-449a ZDHHC16
PAR-CLIP [23]
hsa-miR-449a FAM104A
PAR-CLIP [22]
hsa-miR-449a HSPA1B
PAR-CLIP [22]
hsa-miR-449a MYC
TRAP [24]
hsa-miR-449a MAZ
PAR-CLIP [5]
hsa-miR-449a TXNIP
PAR-CLIP [13] [22]
hsa-miR-449a DCTN5
PAR-CLIP [13]
hsa-miR-449a CCL22
PAR-CLIP [5]
hsa-miR-449a GIGYF1
PAR-CLIP [13] [25]
hsa-miR-449a MDM4
PAR-CLIP [5]
hsa-miR-449a SMAD4
PAR-CLIP [22]
hsa-miR-449a TSN
PAR-CLIP [22] [5]
hsa-miR-449a CBX3
PAR-CLIP [23]
hsa-miR-449a EVI5L
PAR-CLIP [23]
hsa-miR-449a ZNF551
PAR-CLIP [13] [22]
hsa-miR-449a TGFBR2
PAR-CLIP [26]
hsa-miR-449a TM9SF3
PAR-CLIP [13] [22] [23]
hsa-miR-449a UBXN2B
PAR-CLIP [13]
hsa-miR-449a MBD6
PAR-CLIP [5]
hsa-miR-449a ITPR1
qRT-PCR [14]
Western blot [14]
hsa-miR-449a MAP2K1
qRT-PCR [14]
Western blot [14]
hsa-miR-449a DNAAF3
PAR-CLIP [27]
hsa-miR-449a MFSD8
PAR-CLIP [27]
hsa-miR-449a CTIF
PAR-CLIP [27]
hsa-miR-449a GMFB
PAR-CLIP [27]
hsa-miR-449a HIRIP3
PAR-CLIP [5]
hsa-miR-449a GPR156
PAR-CLIP [5]
hsa-miR-449a CNOT4
PAR-CLIP [22] [23] [5]
hsa-miR-449a SLC4A2
PAR-CLIP [5]
hsa-miR-449a PLA2G2D
PAR-CLIP [5]
hsa-miR-449a SPAM1
PAR-CLIP [5]
hsa-miR-449a EFNB1
PAR-CLIP [5]
hsa-miR-449a UST
PAR-CLIP [5]
hsa-miR-449a TNRC18P2
PAR-CLIP [23] [5] [25] [13] [22]
hsa-miR-449a SYNGR2
PAR-CLIP [5]
hsa-miR-449a SF3B3
PAR-CLIP [5]
hsa-miR-449a RGP1
PAR-CLIP [5]
hsa-miR-449a KMT2D
PAR-CLIP [5]
hsa-miR-449a IFNLR1
PAR-CLIP [5]
hsa-miR-449a EDEM3
PAR-CLIP [5]
hsa-miR-449a DYRK3
PAR-CLIP [5]
hsa-miR-449a DDX19B
PAR-CLIP [5]
hsa-miR-449a BAZ2A
PAR-CLIP [5]
hsa-miR-449a ATXN1L
PAR-CLIP [5]
hsa-miR-449a COPZ1
PAR-CLIP [5]
hsa-miR-449a CYTH3
PAR-CLIP [5]
hsa-miR-449a SSBP2
PAR-CLIP [5]
hsa-miR-449a SHMT1
PAR-CLIP [26] [5]
hsa-miR-449a LNPK
PAR-CLIP [5]
hsa-miR-449a NEUROD2
PAR-CLIP [5]
hsa-miR-449a MKNK2
PAR-CLIP [5]
hsa-miR-449a FOXN3
PAR-CLIP [23] [5]
hsa-miR-449a ARHGAP1
PAR-CLIP [22] [23] [5]
hsa-miR-449a MAST3
PAR-CLIP [28]
hsa-miR-449a FICD
PAR-CLIP [13] [22]
hsa-miR-449a ZNF623
PAR-CLIP [13]
hsa-miR-449a RTL8A
PAR-CLIP [13]
hsa-miR-449a ZNF644
PAR-CLIP [13]
hsa-miR-449a TMEM167A
PAR-CLIP [13]
hsa-miR-449a SHOC2
PAR-CLIP [13]
hsa-miR-449a SESN2
PAR-CLIP [13]
hsa-miR-449a SATB2
HITS-CLIP [29]
PAR-CLIP [13] [23]
hsa-miR-449a PHF19
PAR-CLIP [13]
hsa-miR-449a PEG10
PAR-CLIP [13]
hsa-miR-449a CDKN1B
PAR-CLIP [13]
hsa-miR-449a BCL2L13
PAR-CLIP [13] [22]
hsa-miR-449a ZRSR1
PAR-CLIP [13] [22]
hsa-miR-449a XBP1P1
PAR-CLIP [13] [22]
hsa-miR-449a GAS1
PAR-CLIP [13] [22] [23]
hsa-miR-449a UBL4A
PAR-CLIP [13]
hsa-miR-449a VPS37B
PAR-CLIP [13]
hsa-miR-449a SAR1A
PAR-CLIP [13]
hsa-miR-449a RRAGD
PAR-CLIP [13] [22]
hsa-miR-449a C18orf32
PAR-CLIP [26]
hsa-miR-449a RWDD2A
PAR-CLIP [22] [26]
hsa-miR-449a PODXL
PAR-CLIP [26]
hsa-miR-449a KBTBD6
PAR-CLIP [22] [23]
hsa-miR-449a HSPA13
PAR-CLIP [23]
hsa-miR-449a BMP3
PAR-CLIP [23]
hsa-miR-449a SLC35G2
PAR-CLIP [23]
hsa-miR-449a MOAP1
PAR-CLIP [23]
hsa-miR-449a HOXA13
PAR-CLIP [23]
hsa-miR-449a GXYLT2
PAR-CLIP [23]
hsa-miR-449a MIGA1
PAR-CLIP [23]
hsa-miR-449a VPS37D
PAR-CLIP [22]
hsa-miR-449a TPCN2
PAR-CLIP [22]
hsa-miR-449a PAPLN
PAR-CLIP [22]
hsa-miR-449a APOPT1
PAR-CLIP [22]
hsa-miR-449a VASN
PAR-CLIP [22]
hsa-miR-449a VAV3
HITS-CLIP [30] [31]
hsa-miR-449a ITGA11
HITS-CLIP [32] [31]
hsa-miR-449a SSX5
HITS-CLIP [29]
hsa-miR-449a DDA1
HITS-CLIP [29]
hsa-miR-449a CPEB3
HITS-CLIP [29]
hsa-miR-449a CLIC5
HITS-CLIP [29]
hsa-miR-449a IER5
HITS-CLIP [29]
hsa-miR-449a AASDHPPT
HITS-CLIP [29]
hsa-miR-449a ITGB3
HITS-CLIP [29]
hsa-miR-449a POTED
HITS-CLIP [32]
hsa-miR-449a JARID2
HITS-CLIP [32]
hsa-miR-449a MKLN1
HITS-CLIP [33]

References

authors journal year Pubmed link title
1 Yang et al. Genes Dev. 2009 19833767 miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
2 Martinez-Anton et al. Am. J. Respir. Cell Mol. Biol. 2013 23590309 Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells.
3 Li et al. Oncol Lett 2014 25202363 miR-449a and CDK6 in gastric carcinoma.
4 Zhang et al. Oncotarget 2014 24810364 Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a.
5 Whisnant et al. MBio 2013 23592263 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
6 Noonan et al. Oncogene 2009 19252524 miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.
7 Bou Kheir et al. Mol. Cancer 2011 21418558 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer.
8 Noonan et al. Oncotarget 2010 20948989 miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells.
9 Hu et al. Dig. Dis. Sci. 2014 24248414 miR-449a Regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cells.
10 Ramamoorthy et al. Drug Metab. Dispos. 2012 22232426 In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.
11 Wang et al. Biochim. Biophys. Acta 2013 23298640 The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation.
12 Luo et al. PLoS ONE 2013 23734217 MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met.
13 Memczak et al. Nature 2013 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency.
14 An et al. Toxicol. Lett. 2014 24960059 The changes of miRNA expression in rat hippocampus following chronic lead exposure.
15 Wei et al. Oncol Lett 2013 24260067 microRNA-449a functions as a tumor-suppressor in gastric adenocarcinoma by targeting Bcl-2.
16 De Weer et al. Br. J. Haematol. 2011 21569010 EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells.
17 Sarma et al. PLoS ONE 2012 23226395 Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway.
18 Iliopoulos et al. Cancer Res. 2009 19351815 MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
19 Paik et al. Stem Cells Dev. 2012 22769578 miR-449a regulates the chondrogenesis of human mesenchymal stem cells through direct targeting of lymphoid enhancer-binding factor-1.
20 Ren et al. Cancer Lett. 2014 24211326 Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells.
21 Li et al. Cell. Physiol. Biochem. 2015 25871967 MicroRNA-449a inhibits proliferation and induces apoptosis by directly repressing E2F3 in gastric cancer.
22 Hafner et al. Cell 2010 20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
23 Kishore et al. Nat. Methods 2011 21572407 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
24 Braun et al. Nucleic Acids Res. 2014 24510096 Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification).
25 Farazi et al. Genome Biol. 2014 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
26 Lipchina et al. Genes Dev. 2011 22012620 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
27 Gottwein et al. Cell Host Microbe 2011 22100165 Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
28 Skalsky et al. PLoS Pathog. 2012 22291592 The viral and cellular microRNA targetome in lymphoblastoid cell lines.
29 Karginov et al. Genes Dev. 2013 23824327 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
30 Kishore et al. Genome Biol. 2013 23706177 Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.
31 Pillai et al. Breast Cancer Res. Treat. 2014 24906430 HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
32 Xue et al. Cell 2013 23313552 Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
33 Haecker et al. PLoS Pathog. 2012 22927820 Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
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