miRCarta - targets

hsa-miR-106a-5p (MIMAT0000103) (665 targets) in miRTarBase

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miRNA

gene name

experiments

hsa-miR-106a-5p

E2F1


qRT-PCR	[1]
microarray	[2]
Western blot	[2] [3]
Luciferase reporter assay	[3]
Immunohistochemistry	[2]

hsa-miR-106a-5p

CDKN1A


qRT-PCR	[4] [5] [6]
microarray	[4] [7]
Reporter assay	[6]
Western blot	[6] [4] [5] [8]
Other	[6]
Luciferase reporter assay	[4] [5] [8] [6]

hsa-miR-106a-5p

HIPK3


microarray	[7]
Luciferase reporter assay	[9]

hsa-miR-106a-5p

MYLIP


microarray	[7]
Western blot	[9]
Other	[9]
HITS-CLIP	[10] [11]
Luciferase reporter assay	[9]
PAR-CLIP	[12] [13] [14] [11] [15]

hsa-miR-106a-5p

RB1


qRT-PCR	[16] [17]
microarray	[2] [7] [18] [19]
Reporter assay	[19]
Western blot	[19] [16] [2]
Luciferase reporter assay	[16] [19]
Immunohistochemistry	[2] [17]
PAR-CLIP	[11]
immunohistochemistry	[18]

hsa-miR-106a-5p

RUNX1


qRT-PCR	[20]
Western blot	[20]
Luciferase reporter assay	[20]

hsa-miR-106a-5p

ARID4B


microarray	[7]
Western blot	[9]
Other	[9]
Luciferase reporter assay	[9]
PAR-CLIP	[11] [15]

hsa-miR-106a-5p

VEGFA


microarray	[7]
Luciferase reporter assay	[21]
ELISA	[21]

hsa-miR-106a-5p

IL10


qRT-PCR	[22]
Luciferase reporter assay	[22]

hsa-miR-106a-5p

FAS


Luciferase reporter assay	[23]

Show entries

References

	authors	journal	year	Pubmed link	title
1	Díaz et al.	Genes Chromosomes Cancer	2008	18521848	Deregulated expression of miR-106a predicts survival in human colon cancer patients.
2	Kovalchuk et al.	Carcinogenesis	2010	20643754	microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways.
3	Yang et al.	J. Mol. Med.	2011	21656380	MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status.
4	Zhou et al.	Proc. Natl. Acad. Sci. U.S.A.	2010	20385818	High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2.
5	Wu et al.	Oncogene	2010	20190813	Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region.
6	Ivanovska et al.	Mol. Cell. Biol.	2008	18212054	MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
7	Huh et al.	Br. J. Cancer	2013	23807165	Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer.
8	Li et al.	Mech. Ageing Dev.	2009	19782699	Alterations in microRNA expression in stress-induced cellular senescence.
9	Landais et al.	Cancer Res.	2007	17575136	Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.
10	Xue et al.	Cell	2013	23313552	Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
11	Kishore et al.	Nat. Methods	2011	21572407	A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins.
12	Farazi et al.	Genome Biol.	2014	24398324	Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
13	Memczak et al.	Nature	2013	23446348	Circular RNAs are a large class of animal RNAs with regulatory potency.
14	Hafner et al.	Cell	2010	20371350	Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
15	Whisnant et al.	MBio	2013	23592263	In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.
16	Jiang et al.	Toxicol. Sci.	2011	20889678	miR-106a-mediated malignant transformation of cells induced by anti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide.
17	Xiao et al.	Clin. Chim. Acta	2009	18996365	Detection of miR-106a in gastric carcinoma and its clinical significance.
18	Guo et al.	J. Gastroenterol. Hepatol.	2009	19175831	Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues.
19	Volinia et al.	Proc. Natl. Acad. Sci. U.S.A.	2006	16461460	A microRNA expression signature of human solid tumors defines cancer gene targets.
20	Fontana et al.	Nat. Cell Biol.	2007	17589498	MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation.
21	Ye et al.	PLoS ONE	2008	18320040	The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation.
22	Sharma et al.	Proc. Natl. Acad. Sci. U.S.A.	2009	19307576	Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a.
23	Wang et al.	Mol. Carcinog.	2013	22431000	miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS.
24	Feng et al.	PLoS ONE	2012	22912877	Colorectal cancer migration and invasion initiated by microRNA-106a.
25	Lipchina et al.	Genes Dev.	2011	22012620	Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
26	Kumar et al.	Mol. Cell. Biol.	2013	23438603	The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation.
27	Fang et al.	Acta Biochim. Biophys. Sin. (Shanghai)	2013	24108762	miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells.
28	Zhu et al.	J. Allergy Clin. Immunol.	2013	23562609	MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α.
29	Helwak et al.	Cell	2013	23622248	Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.
30	Dai et al.	BMC Cancer	2013	24124917	Decreased miR-106a inhibits glioma cell glucose uptake and proliferation by targeting SLC2A3 in GBM.
31	Li et al.	Stem Cell Res	2013	23399447	miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells.
32	He et al.	Stem Cells	2013	23836497	MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1.
33	Zhang et al.	Brain Res.	2013	23399684	Regulation of STAT3 by miR-106a is linked to cognitive impairment in ovariectomized mice.
34	Guo et al.	Clin. Cancer Res.	2013	23857602	Estrogen receptor α regulates ATM Expression through miRNAs in breast cancer.
35	Zhang et al.	FEBS Lett.	2013	23932924	MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3.
36	Zhu et al.	FEBS Lett.	2014	24440352	MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric cancer.
37	Li et al.	FEBS Lett.	2014	24444603	Upregulated miR-106a plays an oncogenic role in pancreatic cancer.
38	Wu et al.	PLoS ONE	2012	23029228	The miR-17 family links p63 protein to MAPK signaling to promote the onset of human keratinocyte differentiation.
39	Naka-Kaneda et al.	Proc. Natl. Acad. Sci. U.S.A.	2014	24474786	The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells.
40	Karginov et al.	Genes Dev.	2013	23824327	Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
41	Liu et al.	Mol. Cancer Res.	2013	24045973	miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma.
42	Gottwein et al.	Cell Host Microbe	2011	22100165	Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
43	Arabi et al.	Genes Cancer	2014	24955218	Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences.
44	Skalsky et al.	PLoS Pathog.	2012	22291592	The viral and cellular microRNA targetome in lymphoblastoid cell lines.
45	Chi et al.	Nature	2009	19536157	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
46	Pillai et al.	Breast Cancer Res. Treat.	2014	24906430	HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer.
47	Haecker et al.	PLoS Pathog.	2012	22927820	Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
48	Kishore et al.	Genome Biol.	2013	23706177	Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing.

Targets miRBase

hsa-miR-106a-5p (MIMAT0000103) (665 targets) in miRTarBase

References